e-Article
Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography.
Document Type
Academic Journal
Author
Sharma P; Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India. priyanka@rrcat.gov.in.; Homi Bhabha National Institute, Mumbai, 400094, India. priyanka@rrcat.gov.in.; Verma Y; Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.; Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.; Sahu K; Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.; Kumar S; Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.; Varma AV; Sri Aurobindo Medical College and P. G. Institute, Indore, 452013, India.; Kumawat J; Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India.; Gupta PK; Homi Bhabha National Institute, Mumbai, 400094, India.
Source
Publisher: Springer Country of Publication: England NLM ID: 8611515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-604X (Electronic) Linking ISSN: 02688921 NLM ISO Abbreviation: Lasers Med Sci Subsets: MEDLINE
Subject
Language
English
Abstract
We report the use of spectral domain polarization sensitive optical coherence tomography for ex-vivo imaging of human oral mandibular tissue samples. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of A-scan intensity profile, a much larger degree of change was observed in the phase retardation for tissue sites progressing from normal to the malignant state. These results suggest that monitoring of tissue retardance can help in better differentiation of normal and cancerous oral tissue sites.