e-Article
Association of Baseline Pre-Diagnosis and Post-Diagnosis Obesity and Weight Change with Cardiovascular Risk and Survival Among Nonmetastatic Prostate Cancer Survivors.
Document Type
Academic Journal
Author
Dindinger-Hill K; Huntsman Cancer Institute, Salt Lake City, UT.; Hu S; Huntsman Cancer Institute, Salt Lake City, UT; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT.; Hickman A; Davidson College, Davidson, NC.; Choudry M; Department of Urology, Mayo Clinic, Phoenix, AZ.; Vehawn J; Huntsman Cancer Institute, Salt Lake City, UT.; Snyder J; Intermountain Healthcare, Salt Lake City, UT.; Deshmukh V; University of Utah Health Sciences Center, Salt Lake City, UT.; Newman M; University of Utah Health Sciences Center, Salt Lake City, UT.; Date A; Pedigree and Population Resource, Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT.; Galvao C; Pedigree and Population Resource, Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT.; Kohli M; Huntsman Cancer Institute, Salt Lake City, UT; Division of Oncology, Department of Medicine, University of Utah, Salt Lake City, UT.; O'Neil B; Huntsman Cancer Institute, Salt Lake City, UT.; Schmidt B; Huntsman Cancer Institute, Salt Lake City, UT.; Dechet C; Huntsman Cancer Institute, Salt Lake City, UT.; Hashibe M; Huntsman Cancer Institute, Salt Lake City, UT; Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT.; Sanchez A; Huntsman Cancer Institute, Salt Lake City, UT. Electronic address: alejandro.sanchez@hci.utah.edu.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 101260955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0682 (Electronic) Linking ISSN: 15587673 NLM ISO Abbreviation: Clin Genitourin Cancer Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Obesity in prostate cancer survivors may increase mortality. Better characterization of this effect may allow better counseling on obesity as a targetable lifestyle factor to reduce mortality in prostate cancer survivors. The purpose of this study was to determine whether pre- and post-diagnostic obesity and weight change affect all-cause mortality, cardiovascular disease specific mortality, and prostate cancer specific mortality in patients with nonmetastatic prostate cancer.
Patients and Methods: We performed a retrospective cohort analysis of 5,077 patients diagnosed with localized prostate cancer from 1997 to 2017 with median follow-up of 15.5 years. The Utah Population Database linked to the Utah Cancer Registry was used to identify patients at a variety of treatment centers.
Results: Pre-diagnosis obesity was associated with a 62% increased risk of cardiovascular disease specific mortality and a 34% increased risk of all-cause mortality (HR 1.62, 95% CI 1.05-2.50; HR 1.34, 95% CI 1.07-1.67, respectively). Post-diagnosis obesity increased the risk of cardiovascular disease specific mortality (HR 1.83, 95% CI 1.31-2.56) and all-cause mortality (HR 1.37, 95% CI 1.16-1.64) relative to non-obese men. We found no association between pre-diagnostic obesity or post-diagnostic weight gain and prostate cancer specific mortality.
Conclusion: Our study strengthens the conclusion that pre-, post-diagnostic obesity and weight gain increase cardiovascular disease and all-cause mortality but not prostate cancer specific mortality compared to healthy weight men. An increased emphasis on weight management may improve mortality for prostate cancer survivors who are obese.
(Copyright © 2024. Published by Elsevier Inc.)
Patients and Methods: We performed a retrospective cohort analysis of 5,077 patients diagnosed with localized prostate cancer from 1997 to 2017 with median follow-up of 15.5 years. The Utah Population Database linked to the Utah Cancer Registry was used to identify patients at a variety of treatment centers.
Results: Pre-diagnosis obesity was associated with a 62% increased risk of cardiovascular disease specific mortality and a 34% increased risk of all-cause mortality (HR 1.62, 95% CI 1.05-2.50; HR 1.34, 95% CI 1.07-1.67, respectively). Post-diagnosis obesity increased the risk of cardiovascular disease specific mortality (HR 1.83, 95% CI 1.31-2.56) and all-cause mortality (HR 1.37, 95% CI 1.16-1.64) relative to non-obese men. We found no association between pre-diagnostic obesity or post-diagnostic weight gain and prostate cancer specific mortality.
Conclusion: Our study strengthens the conclusion that pre-, post-diagnostic obesity and weight gain increase cardiovascular disease and all-cause mortality but not prostate cancer specific mortality compared to healthy weight men. An increased emphasis on weight management may improve mortality for prostate cancer survivors who are obese.
(Copyright © 2024. Published by Elsevier Inc.)