e-Article
Low-Dose CT-derived Bronchial Parameters in Individuals with Healthy Lungs.
Document Type
Academic Journal
Author
Dudurych I; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; Pelgrim GJ; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; Sidorenkov G; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; Garcia-Uceda A; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; Petersen J; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; Slebos DJ; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; de Bock GH; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; van den Berge M; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; de Bruijne M; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).; Vliegenthart R; From the Departments of Radiology (I.D., G.J.P., G.S., R.V.), Epidemiology (G.S., G.H.d.B.), and Pulmonology (D.J.S., M.v.d.B.), University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700 GZ Groningen, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands (A.G.U., M.d.B.); Department of Computer Science, Copenhagen University, Copenhagen, Denmark (J.P., M.d.B.); and Department of Oncology, Rigshospitalet, Copenhagen, Denmark (J.P.).
Source
Publisher: Radiological Society of North America Country of Publication: United States NLM ID: 0401260 Publication Model: Print Cited Medium: Internet ISSN: 1527-1315 (Electronic) Linking ISSN: 00338419 NLM ISO Abbreviation: Radiology Subsets: MEDLINE
Subject
Language
English
Abstract
Background CT-derived bronchial parameters have been linked to chronic obstructive pulmonary disease and asthma severity, but little is known about these parameters in healthy individuals. Purpose To investigate the distribution of bronchial parameters at low-dose CT in individuals with healthy lungs from a Dutch general population. Materials and Methods In this prospective study, low-dose chest CT performed between May 2017 and October 2022 were obtained from participants who had completed the second-round assessment of the prospective, longitudinal Imaging in Lifelines study. Participants were aged at least 45 years, and those with abnormal spirometry, self-reported respiratory disease, or signs of lung disease at CT were excluded. Airway lumens and walls were segmented automatically. The square root of the bronchial wall area of a hypothetical airway with an internal perimeter of 10 mm (Pi10), luminal area (LA), wall thickness (WT), and wall area percentage were calculated. Associations between sex, age, height, weight, smoking status, and bronchial parameters were assessed using univariable and multivariable analyses. Results The study sample was composed of 8869 participants with healthy lungs (mean age, 60.9 years ± 10.4 [SD]; 4841 [54.6%] female participants), including 3672 (41.4%) never-smokers and 1197 (13.5%) individuals who currently smoke. Bronchial parameters for male participants were higher than those for female participants (Pi10, slope [β] range = 3.49-3.66 mm; LA, β range = 25.40-29.76 mm 2 ; WT, β range = 0.98-1.03 mm; all P < .001). Increasing age correlated with higher Pi10, LA, and WT ( r 2 range = 0.06-0.09, 0.02-0.01, and 0.02-0.07, respectively; all P < .001). Never-smoking individuals had the lowest Pi10 followed by formerly smoking and currently smoking individuals (3.62 mm ± 0.13, 3.68 mm ± 0.14, and 3.70 mm ± 0.14, respectively; all P < .001). In multivariable regression models, age, sex, height, weight, and smoking history explained up to 46% of the variation in bronchial parameters. Conclusion In healthy individuals, bronchial parameters differed by sex, height, weight, and smoking history; male sex and increasing age were associated with wider lumens and thicker walls. © RSNA, 2024 Supplemental material is available for this article. See also the editorial by Emrich and Varga-Szemes in this issue.