e-Article
Respiratory Syncytial Virus Reinfections in Children in Western Australia.
Document Type
Academic Journal
Author
Foley DA; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia.; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.; School of Medicine, University of Western Australia, Perth, WA 6009, Australia.; Minney-Smith CA; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia.; Lee WH; School of Medicine, University of Western Australia, Perth, WA 6009, Australia.; Department of General Paediatrics, Perth Children's Hospital, Nedlands, WA 6009, Australia.; Oakes DB; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.; Hazelton B; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia.; Department of Infectious Diseases, Perth Children's Hospital, Nedlands, WA 6009, Australia.; Ford TJ; School of Medicine, University of Western Australia, Perth, WA 6009, Australia.; Department of Infectious Diseases, Perth Children's Hospital, Nedlands, WA 6009, Australia.; Wadia U; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.; Department of Infectious Diseases, Perth Children's Hospital, Nedlands, WA 6009, Australia.; Department of General Paediatrics, Fiona Stanley Hospital, Murdoch, WA 6150, Australia.; Sikazwe C; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia.; Marshall Centre for Infectious Diseases, School of Biomedical Sciences, University of Western Australia, Perth, WA 6009, Australia.; Moore HC; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.; School of Population Health, Curtin University, Perth, WA 6009, Australia.; Nicol MP; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.; Marshall Centre, Biomedical Sciences, University of Western Australia, Perth, WA 6009, Australia.; Levy A; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia.; Marshall Centre for Infectious Diseases, School of Biomedical Sciences, University of Western Australia, Perth, WA 6009, Australia.; Blyth CC; Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia.; Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.; School of Medicine, University of Western Australia, Perth, WA 6009, Australia.; Department of Infectious Diseases, Perth Children's Hospital, Nedlands, WA 6009, Australia.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
Subject
Language
English
Abstract
Respiratory syncytial virus (RSV) reinfection in children is poorly understood. We examined the incidence, characteristics, and outcomes of hospital-attended RSV reinfections in children <16 years in Western Australia between 2012 and 2022. Individuals with repeat RSV detections ≥56 days apart were identified using laboratory data. The incidence of reinfection in the first five years of life was estimated using the total birth population from 2012 to 2017. Clinical data on a subset of reinfection episodes were obtained from two metropolitan pediatric centers. A total of 466 children with hospital-attended reinfections were identified. The median interval between RSV detections was 460 days (interquartile range: 324, 812), with a reinfection rate of 95 per 100,000 individuals (95% confidence interval: 82, 109). Reinfection was most common in children who experienced their first RSV detection <6 months of age. Predisposing factors were identified in 56% of children; children with predisposing factors were older at first and second detections, were more likely to be admitted, and had a longer length of stay. This study highlights the significant burden of hospital-attended RSV reinfections in children with and without predisposing factors. Expanded surveillance with in-depth clinical data is required to further characterize the impact of RSV reinfection.