e-Article
Transanal approach after preoperative imatinib treatment of a rectal gastrointestinal stromal tumors with external anal sphincter invasion: A case report.
Document Type
Academic Journal
Author
Hisanaga M; Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan. Electronic address: hisanaga-makoto@isahaya.jcho.go.jp.; Nonaka T; Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Maruta H; Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan.; Maruyama K; Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan.; Fukuoka H; Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan.; Yamaguchi H; Department of Surgery, Japan Community Health Care Organization Isahaya General Hospital, Nagasaki, Japan.
Source
Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101529872 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2210-2612 (Print) Linking ISSN: 22102612 NLM ISO Abbreviation: Int J Surg Case Rep Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2210-2612
Abstract
Introduction and Importance: Rectal gastrointestinal stromal tumors (GISTs) are rare, and preserving anorectal function can be challenging. We report the case of a patient with rectal GIST with external anal sphincter invasion, treated via the laparoscopic and transanal approaches.
Case Presentation: A 61-year-old man with locally advanced GIST in the right anterolateral wall of the lower rectum was examined. Lower endoscopy revealed a 50-mm submucosal tumor located 4 cm from the anal verge. On immunohistochemistry, the biopsy specimen tested positive for CD34 and C-KIT, and the patient was diagnosed with GIST. Abdominal magnetic resonance imaging (MRI) revealed external anal sphincter infiltration. Because of the large tumor size and proximity to the anal verge, preserving the anus was challenging, and colorectal resection was avoided. Instead, neoadjuvant therapy with imatinib was administered to facilitate local resection of the tumor. Post-treatment MRI showed a reduction in tumor size (30 × 20 × 30 mm), and surgery was performed. We identified an appropriate resection line for diplomatic sphincter resection of the infiltrated area by laparoscopy alone. Thus, we performed a hybrid surgery using the laparoscopic and transanal approaches. The patient had an unremarkable postoperative course and was discharged on postoperative day 23.
Clinical Discussion: No study has reported cases of rectal GIST with external anal sphincter invasion wherein anal function was preserved. Here, imatinib was administered preoperatively, and hybrid surgery was performed using the transanal and laparoscopic approaches.
Conclusion: Preoperative treatment and surgery preserved anorectal function in a patient with a massive rectal GIST.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Case Presentation: A 61-year-old man with locally advanced GIST in the right anterolateral wall of the lower rectum was examined. Lower endoscopy revealed a 50-mm submucosal tumor located 4 cm from the anal verge. On immunohistochemistry, the biopsy specimen tested positive for CD34 and C-KIT, and the patient was diagnosed with GIST. Abdominal magnetic resonance imaging (MRI) revealed external anal sphincter infiltration. Because of the large tumor size and proximity to the anal verge, preserving the anus was challenging, and colorectal resection was avoided. Instead, neoadjuvant therapy with imatinib was administered to facilitate local resection of the tumor. Post-treatment MRI showed a reduction in tumor size (30 × 20 × 30 mm), and surgery was performed. We identified an appropriate resection line for diplomatic sphincter resection of the infiltrated area by laparoscopy alone. Thus, we performed a hybrid surgery using the laparoscopic and transanal approaches. The patient had an unremarkable postoperative course and was discharged on postoperative day 23.
Clinical Discussion: No study has reported cases of rectal GIST with external anal sphincter invasion wherein anal function was preserved. Here, imatinib was administered preoperatively, and hybrid surgery was performed using the transanal and laparoscopic approaches.
Conclusion: Preoperative treatment and surgery preserved anorectal function in a patient with a massive rectal GIST.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)