e-Article
Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation.
Document Type
Academic Journal
Author
Ramosaj M; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Madsen S; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Maillard V; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Scandella V; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Sudria-Lopez D; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Yuizumi N; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.; Telley L; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.; Knobloch M; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. marlen.knobloch@unil.ch.
Source
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Subject
Language
English
Abstract
Neural stem/progenitor cells (NSPCs) generate new neurons throughout adulthood. However, the underlying regulatory processes are still not fully understood. Lipid metabolism plays an important role in regulating NSPC activity: build-up of lipids is crucial for NSPC proliferation, whereas break-down of lipids has been shown to regulate NSPC quiescence. Despite their central role for cellular lipid metabolism, the role of lipid droplets (LDs), the lipid storing organelles, in NSPCs remains underexplored. Here we show that LDs are highly abundant in adult mouse NSPCs, and that LD accumulation is significantly altered upon fate changes such as quiescence and differentiation. NSPC proliferation is influenced by the number of LDs, inhibition of LD build-up, breakdown or usage, and the asymmetric inheritance of LDs during mitosis. Furthermore, high LD-containing NSPCs have increased metabolic activity and capacity, but do not suffer from increased oxidative damage. Together, these data indicate an instructive role for LDs in driving NSPC behaviour.
(© 2021. The Author(s).)
(© 2021. The Author(s).)