e-Article
Comprehensive profiling of H-Ras signalling in angiosarcoma endothelium.
Document Type
Article
Author
Source
Subject
*HRAS genes
*ANGIOSARCOMA
*ENDOTHELIUM diseases
*ENDOTHELIAL cells
*ONCOGENIC viruses
*CELL lines
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Language
ISSN
0307-6938
Abstract
The MS1/ SVR system, in which MS1 represents immortalized endothelial cells and SVR represents MS1 cells transformed with oncogenic human-rat sarcoma protein (H-Ras), has been used for around 20 years as a valuable tool to study angiogenesis and carcinogenesis. Despite the use of these cells in numerous studies, a comprehensive profile of the signalling differences due to oncogenic H-Ras transformation has not been performed previously. In this study, we profiled the well-known MS1 and SVR cell lines using a combination of both Western blot and gene chip assays. [ABSTRACT FROM AUTHOR]