e-Article
Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter.
Document Type
Article
Source
Subject
*OBESITY
*METABOLIC disorders
*ADIPOSE tissues
*LIPASES
*CONNECTIVE tissues
*FATTY acids
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Language
ISSN
0027-8424
Abstract
The article discusses obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter. Adipocytes are a dynamic reservoir for storage of energy in the absorptive phase and release of energy in the post absorptive phase. Glycerol is a key metabolite that plays an important role in adipose tissue, largely by serving as the carbon backbone for triacylglycerol. During the post absorptive state and exercise, triacylglycerol is hydrolyzed by hormone-sensitive lipase and adipose triglyceride lipase to glycerol and free fatty acids, both of which are released into the bloodstream.