e-Article
Chromosomal breaks: another differential gap between early-onset and late-onset colorectal cancers.
Document Type
Article
Author
Perea, José; García, Juan Luis; Corchete, Luis A; Martí, Marc; Hernández-Villafranca, Sergio; Alcázar, José A; Álvaro, Edurne; Hurtado, Elena; Jiménez-Toscano, Marta; Balaguer, Francesc; Ballestero, Araceli; López-Rojo, Irene; Jiménez, Fernando; Sanz, Gonzalo; Melone, Sirio; Brandáriz, Lorena; Vivas, Alfredo; Alvarellos, Alicia; González-Sarmiento, Rogelio; Rueda-Orgaz, José A
Source
Subject
*COLORECTAL cancer
*TUMOR suppressor genes
*CHROMOSOME replication
*RECTAL cancer
*COLON cancer
*RNA polymerase II
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Language
ISSN
0007-1323
Abstract
This document summarizes a study on early-onset colorectal cancer (EOCRC) and late-onset colorectal cancer (LOCRC). The study found that there are genetic differences between these two types of colorectal cancer based on the age of onset. Recurrent breakpoints and common fragile sites were identified in both cohorts, and a specific gene, CPEB1, was implicated in EOCRC. Further research is needed to confirm these findings and investigate potential treatment options for EOCRC. [Extracted from the article]