e-Article
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion.
Document Type
Journal Article
Author
Source
Subject
*CHRONIC wasting disease
*PRIONS
*HOST specificity (Biology)
*GENOTYPES
*TRANSGENIC mice
*INFECTIOUS disease transmission
*
*
*
*
*
Language
ISSN
1080-6040
Abstract
Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95+, into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains. [ABSTRACT FROM AUTHOR]