e-Article
SNPs in PPARG Associate with Type 2 Diabetes and Interact with Physical Activity.
Document Type
Article
Author
Source
Subject
*GENETIC polymorphisms
*PEROXISOMES
*GLUCOSE tolerance tests
*TYPE 2 diabetes
*EXERCISE
*WELL-being
*LIFESTYLES
*PHYSICAL fitness
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Language
ISSN
0195-9131
Abstract
The article focuses on the significance of the seven single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor gamma (PPARG) gene from impaired glucose tolerance (IGT) to type 2 diabetes (T2D). Findings shows that Pro12Ala polymorphism in PPARG tends to increase the risk of conversion from IGT to T2D in the Diabetes Prevention Study (DPS) in contrast to the increase in leisure-time physical activity removed the effect of the risk alleles. Furthermore, lifestyle intervention of the DPS modified the association of the rs1152003 polymorphism of PPARG with the risk of T2D.