e-Article
Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation.
Document Type
Article
Author
Source
Subject
*CYTOSKELETON
*MAJOR histocompatibility complex
*ANTIGEN presentation
*ENDOCYTOSIS
*ANTIGEN presenting cells
*CELL migration
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Language
ISSN
0105-2896
Abstract
Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells ( APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells ( DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space. [ABSTRACT FROM AUTHOR]