부산대학교 도서관

Summary: Burkitt lymphoma (BL) is an aggressive B‐cell‐malignancy derived from germinal‐centre B‐cells. Curative therapy traditionally requires intensive immunochemotherapy. Recently, immuno‐oncological approaches, modulating the T‐cell tumour response, were approved for the treatment of a variety of malignancies. The architecture of the tumour‐infiltrating T‐cell receptor (TCR) repertoire in BL remains insufficiently characterized. We therefore performed a large‐scale, next‐generation sequencing study of the complimentary‐determining region (CDR)‐3 region of the TCRβ chain repertoire in a large cohort of all epidemiological subtypes of BL (n = 82) and diffuse large B‐cell lymphoma (DLBCL; n = 34). Molecular data were subsequently assessed for correlation with clinical outcome. Our investigations revealed an age‐dependent immunoprofile in BL as in DLBCL. Moreover, we found several public clonotypes in numerous patients suggestive of shared tumour neoantigen selection exclusive to BL and distinct from DLBCL regardless of Epstein–Barr virus and/or human immunodeficiency virus status. Compared with baseline, longitudinal analysis unveiled significant repertoire restrictions upon relapse (P = 0·0437) while productive TCR repertoire clonality proved to be a useful indicator of both overall and progression‐free‐survival [OS: P = 0·0001; hazard ratio (HR): 6·220; confidence interval (CI): 2·263–11·78; PFS: P = 0·0025; HR: 3·086; CI: 1·555–7·030]. Multivariate analysis confirmed its independence from established prognosticators, including age at diagnosis and comorbidities. Our findings establish the clinical relevance of the architecture and clonality of the TCR repertoire and its age‐determined dynamics in BL. [ABSTRACT FROM AUTHOR]