e-Article
LGI1 antibody‐associated limbic encephalitis started from unilateral basal ganglia to medial temporal lobe and insula.
Document Type
Article
Author
Source
Subject
*TEMPORAL lobe
*BASAL ganglia
*ENCEPHALITIS
*ANTI-NMDA receptor encephalitis
*MAGNETIC resonance imaging
*TREMOR
*ARM
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Language
ISSN
2049-4173
Abstract
Leucine‐rich glioma‐inactivated 1 (LGI1) antibody‐associated limbic encephalitis is a rare autoimmune encephalitis. Here, we report a 39‐year‐old woman presented with generalized tonic‐clonic seizures, night delirium, bilateral upper limb tremor, and hyponatremia. Her symptoms did not improve with initial steroid therapy, and brain magnetic resonance imaging (MRI) showed a progression of abnormalities from right basal ganglia to medial temporal lobe and insula. The presence of LGI1 antibodies in the patient's serum confirmed the clinical diagnosis. After the combined treatments of methylprednisolone, plasma exchange, and intravenous immunoglobulin, her clinical symptoms resolved completely. [ABSTRACT FROM AUTHOR]