e-Article
Treatment outcomes for infantile spasms in Japanese children with Down syndrome.
Document Type
Article
Author
Source
Subject
*ANTICONVULSANTS
*INFANTILE spasms
*ELECTROENCEPHALOGRAPHY
*CONFIDENCE intervals
*DOWN syndrome
*RETROSPECTIVE studies
*TREATMENT effectiveness
*DOSE-effect relationship in pharmacology
*DESCRIPTIVE statistics
*ODDS ratio
*ADRENOCORTICOTROPIC hormone
*DISEASE remission
*CHILDREN
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Language
ISSN
1328-8067
Abstract
Background: The aim of this study was to assess the treatment response to conventional antiepileptic drugs and low‐dose adrenocorticotropic hormone therapy for infantile spasms in children with Down syndrome. Methods: We retrospectively investigated the response and relapse rates, electroencephalography findings, patient characteristics during drug withdrawal, and developmental outcome in 10 children with Down syndrome treated for infantile spasms in our hospital. Results: All patients showed cessation of infantile spasms and achieved electroencephalographic normalization. Spasm relapse occurred in one of 10 patients (10%). Antiepileptic drugs have been withdrawn for seven of 10 patients (70%), none of whom have experienced seizure relapse since drug withdrawal. The median developmental quotient (n = 8) was 20.5, which shows that the developmental outcome was unfavorable. Low‐dose adrenocorticotropic hormone therapy achieved a low seizure remission rate of 28.6%. Conclusions: Elucidation of the optimal treatment for infantile spasms in children with Down syndrome is needed to reduce the duration of infantile spasms and improve the developmental outcome. [ABSTRACT FROM AUTHOR]