e-Article
Corticosteroid tapering is a safe approach in patients with relapsed or refractory multiple myeloma receiving subcutaneous daratumumab: part 3 of the open-label, multicenter, phase 1b PAVO study.
Document Type
Article
Author
Source
Subject
*STEM cell transplantation
*MULTIPLE myeloma
*DARATUMUMAB
*PAVO
*PATIENT safety
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Language
ISSN
1042-8194
Abstract
These results indicate that corticosteroid tapering does not diminish DARA SC monotherapy efficacy, as patients who received DARA SC with/without tapering achieved similar efficacy [[3], [15]]. No patients evaluable for daratumumab immunogenicity were positive for anti-daratumumab antibodies, indicating a low risk for immunogenicity for DARA SC with corticosteroid tapering. All patients experienced >=1 TEAE; 21 (50.0%) patients reported a grade >=3 TEAE, and 16 (38.1%) patients experienced a serious TEAE. [Extracted from the article]