부산대학교 도서관

We report here a comparative study of the effects of Russian-produced derivatives of 3-hydroxypyridine and succinic acid (emoxypine, Reamberin, and Mexidol) on the resistance of mice to acute adrenaline intoxication and formalin edema. The corresponding effects of α-lipoic acid (α-LA) were also studied - this has previously been used as a reference agent in assessments of the antihypoxic activity of 3-hydroxypyridine and succinic acid derivatives. Single doses of emoxypine, Reamberin, Mexidol, and α-LA at the optimum doses, corresponding to the therapeutic range for humans, were found to increase the duration of life in mice dying from acute adrenaline intoxication. α-LA was found to decrease formalin edema, while emoxypine and Mexidol increased its severity. The protective effects of all compounds tested against adrenalin intoxication were found to increase in direct proportion to their ability to increase formalin edema. [ABSTRACT FROM AUTHOR]