e-Article
Different immune contextures underlie tumor site‐specific responses to immune checkpoint blockade in esophageal cancer.
Document Type
Article
Author
Source
Subject
*DRUG efficacy
*IMMUNE checkpoint inhibitors
*IMMUNOHISTOCHEMISTRY
*TREATMENT effectiveness
*GENE expression
*COMPUTED tomography
*TUMOR markers
*ESOPHAGEAL tumors
*
*
*
*
*
*
*
Language
ISSN
1759-7706
Abstract
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in advanced esophageal squamous cell carcinoma (ESCC). Heterogeneous responses to ICIs have been reported previously. Here, we describe a patient with advanced ESCC exhibiting a response to durvalumab plus tremelimumab for more than 6 months except primary resistant esophageal tumor. The esophageal tumor had higher regulatory T cells, neutrophils, and mast cells scores estimated by NanoString platform than hepatic tumor. The immunohistochemistry study confirmed higher expression levels of Foxp3, and myeloperoxidase (MPO) in the esophageal tumor. The different immune contextures may underlie the heterogeneous responses to ICI combination in this ESCC patient. [ABSTRACT FROM AUTHOR]