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e-Article

Clusterin is increased in morphologically normal cardiomyocytes in lymphocytic myocarditis.
Document Type
Article
Source
European Journal of Clinical Investigation. Mar2023, Vol. 53 Issue 3, p1-6. 6p.
Subject
*CLUSTERIN
*MYOCARDITIS
*COCAINE
*COCAINE-induced disorders
*ECULIZUMAB
*TUKEY'S test
Language
ISSN
0014-2972
Abstract
We previously observed an increased presence of the stress response protein clusterin in the hearts of acute myocardial infarction patients.[3] Herein, clusterin was not only present in necrotic cardiomyocytes but also in viable morphologically normal cardiomyocytes in the noninfarcted myocardium. Keywords: cardiomyocytes; clusterin; lymphocytic myocarditis; viral myocarditis EN cardiomyocytes clusterin lymphocytic myocarditis viral myocarditis 1 6 6 02/14/23 20230301 NES 230301 INTRODUCTION Myocarditis is an inflammatory disease of the heart that is most commonly caused by a viral infection of the heart. Clusterin+ cardiomyocytes were found scattered across the left ventricle in LM patients and the staining intensity of clusterin varied between cardiomyocytes (Figure 1B). [Extracted from the article]