e-Article
Axonal transport of adeno-associated viral vectors is serotype-dependent.
Document Type
Article
Author
Source
Subject
*AXONAL transport
*ADENO-associated virus
*SEROTYPES
*LABORATORY rats
*HUNTINGTON'S chorea treatment
*GENE therapy
*MEDICAL screening
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Language
ISSN
0969-7128
Abstract
We have previously shown that adeno-associated virus type 2 (AAV2) undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, in the same way as AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype dependent and this has implications for gene therapy of neurological diseases such as Huntington's disease. [ABSTRACT FROM AUTHOR]