부산대학교 도서관

Hashimoto’s thyroiditis (HT), the most frequent autoimmune thyroid disease (AITD), is characterized by chronic inflammation of the thyroid gland that usually results in hypothyroidism. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels are used as clinical determinants of thyroid function. The main aim of this study was to explore the association of established TSH and FT4 genetic variants with HT. We performed a case–control analysis using 23 genetic markers in 200 HT patients and 304 controls. Additionally, we tested the association of selected variants with several thyroid-related quantitative traits in HT cases only. Two genetic variants showed nominal association with HT: rs11935941 nearNR3C2gene (p = 0.0034, OR = 0.57, 95% CI = 0.39–0.83) and rs1537424 nearMBIPgene (p = 0.0169, OR = 0.72, 95% CI = 0.55–0.94). Additionally, three SNPs showed nominal association with thyroglobulin antibody (TgAb) levels: rs4804416 inINSRgene (p = 0.0073,β = −0.51), rs6435953 nearIGFBP5gene (p = 0.0081,β = 0.75), and rs1537424 nearMBIPgene (p = 0.0117,β = 0.49).GLIS3genetic variant rs10974423 showed nominal association with thyroid peroxidase antibody (TPOAb) levels (p = 0.0465,β = −0.56) andNRG1genetic variant rs7825175 was nominally associated with thyroid gland volume (p = 0.0272,β = −0.18). All detected loci were previously related to thyroid function or pathology. Findings from our study suggest biological relevance ofNR3C2andMBIPwith HT, although these loci require additional confirmation in a larger replication study. [ABSTRACT FROM AUTHOR]