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Academic Journal
54 Med. Sci. & L. 167 (2014) / Medicine, Science and the Law, Vol. 54, Issue 3 (July 2014), pp. 167-173
Report
Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects
Academic Journal
Cotton, S.McHugh, M.P.Dewar, R.Haas, J.G.Templeton, K.Robson, Samuel C.Connor, Thomas R.Loman, Nicholas J.Golubchik, TanyaMartinez Nunez, Rocio T.Bonsall, DavidRambaut, AndrewSnell, Luke B.Livett, RichLudden, CatherineCorden, SallyNastouli, EleniNebbia, GaiaJohnston, IanPrieto, Jacqui A.Saeed, KordoJackson, David K.Houlihan, CatherineFrampton, DanHamilton, William L.Witney, Adam A.Bucca, GiseldaPope, Cassie F.Moore, CatherineThomson, Emma C.Cutino-Moguel, TeresaHarrison, Ewan M.Smith, Colin P.Rogan, FionaBeckwith, Shaun M.Murray, AbigailSingleton, DawnEastick, KirstineSheridan, Liz A.Randell, PaulJackson, Leigh M.Ariani, Cristina V.Gonçalves, SóniaFairley, Derek J.Loose, Matthew W.Watkins, JoanneMoses, SamuelNicholls, SamBull, MatthewAmato, RobertoSmith, Darren L.Aanensen, David M.Barrett, Jeffrey C.Kele, BeatrixAggarwal, DineshShepherd, James G.Curran, Martin D.Parmar, SurendraParker, Matthew D.Williams, CatrynGlaysher, SharonUnderwood, Anthony P.Bashton, MatthewPacchiarini, NicoleLoveson, Katie F.Byott, MatthewCarabelli, Alessandro M.Templeton, Kate E.Peacock, Sharon J.de Silva, Thushan I.Wang, DennisLangford, Cordelia F.Sillitoe, JohnGunson, Rory N.Cottrell, SimonO’Grady, JustinKwiatkowski, DominicLillie, Patrick J.Cortes, NicholasMoore, NathanThomas, ClaireBurns, Phillipa J.Mahungu, Tabitha W.Liggett, StevenBeckett, Angela H.Holden, Matthew TG.Levett, Lisa J.Osman, HusamHassan-Ibrahim, Mohammed O.Simpson, David A.Chand, MeeraGupta, Ravi K.Darby, Alistair C.Paterson, StevePybus, Oliver G.Volz, Erik M.de Angelis, DanielaRobertson, David L.Page, Andrew J.Martincorena, InigoAigrain, LouiseBassett, Andrew R.Wong, NickTaha, YusriErkiert, Michelle J.Spencer Chapman, Michael H.Dewar, RebeccaMcHugh, Martin P.Mookerjee, SiddharthAplin, StephenHarvey, MatthewSass, TheaUmpleby, HelenWheeler, HelenMcKenna, James P.Warne, BenTaylor, Joshua F.Chaudhry, YasminIzuagbe, RhysJahun, Aminu S.Young, Gregory R.McMurray, ClaireMcCann, Clare M.Nelson, AndrewElliott, ScottLowe, 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ThomasTan, Ngee KeongBrown, Julianne R.Harris, Kathryn A.Kidd, Stephen P.Grant, Paul R.Xu-McCrae, LiCox, AlisonMadona, PinglawatheePond, MarcusRandell, Paul A.Withell, Karen T.Williams, CherylGraham, CliveDenton-Smith, RebeccaSwindells, EmmaTurnbull, RobynSloan, Tim J.Bosworth, AndrewHutchings, StephaniePymont, Hannah M.Casey, AnnaRatcliffe, LizJones, Christopher R.Knight, Bridget A.Haque, TanzinaHart, JenniferIrish-Tavares, DianneWitele, EricMower, CraigWatson DipHE, Louisa K.Collins, JenniferEltringham, GaryCrudgington, DorianMacklin, BenIturriza-Gomara, MirenLucaci, Anita O.McClure, Patrick C.Carlile, MatthewHolmes, NadineMoore, ChristopherStorey, NathanielRooke, StefanYebra, GonzaloCraine, NoelPerry, MalorieAlikhan, Nabil-FareedBridgett, StephenCook, Kate F.Fearn, ChristopherGoudarzi, SalmanLyons, Ronan A.Williams, ThomasHaldenby, Sam T.Durham, JillianLeonard, StevenDavies, Robert M.Batra, RahulBlane, BethSpyer, Moira J.Smith, PerminderYavus, MehmetWilliams, Rachel J.Mahanama, 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RachaelStarinskij, IgorThomson, LauraSouthgate, JoelKraemer, Moritz UG.Raghwani, JaynaZarebski, Alex E.Boyd, OliviaGeidelberg, LilyIllingworth, Chris J.Jackson, ChrisPascall, DavidVattipally, SreenuFreeman, Timothy M.Hsu, Sharon N.Lindsey, Benjamin B.James, KeithLewis, KevinTonkin-Hill, GerryTovar-Corona, Jaime M.Cox, MacGregorAbudahab, KhalilMenegazzo, MirkoTaylor, Ben EW.Yeats, Corin A.Mukaddas, AfridaWright, Derek W.de Oliveira Martins, LeonardoColquhoun, RachelHill, VerityJackson, BenMcCrone, J.T.Medd, NathanScher, EmilyKeatley, Jon-PaulCurran, TanyaMorgan, SianMaxwell, PatrickSmith, KenEldirdiri, SaharKenyon, AnitaHolmes, Alison H.Price, James R.Wyatt, TimMather, Alison E.Skvortsov, TimofeyHartley, John A.Guest, MartynKitchen, ChristineMerrick, IanMunn, RobertBertolusso, BeatriceLynch, JessicaVernet, GabrielleKirk, StuartWastnedge, ElizabethStanley, RachaelIdle, GilesBradley, Declan T.Killough, Nicholas F.Poyner, JenniferMori, MatildeJones, OwenWright, VictoriaBrooks, EllenaChurcher, Carol M.Delgado Callico, LaiaFragakis, MireilleGalai, KaterinaJermy, AndrewJudges, SarahMarkov, AnnaMcManus, Georgina M.Smith, Kim S.Thomas-McEwen, Peter MD.Westwick, ElaineAttwood, Stephen W.Bolt, FrancesDavies, AlishaDe Lacy, ElenDowning, FatimaEdwards, SueMeadows, LizzieJeremiah, SarahSmith, NikkiFoulser, LukePatel, AmitaBerry, LouiseBoswell, TimFleming, Vicki M.Howson-Wells, Hannah C.Joseph, AmeliaKhakh, ManjinderLister, Michelle M.Bird, Paul W.Fallon, KarlieHelmer, ThomasMcMurray, Claire L.Odedra, MinaShaw, JessicaTang, Julian W.Willford, Nicholas J.Blakey, VictoriaRaviprakash, VeenaSheriff, NicolaWilliams, Lesley-AnneFeltwell, TheresaBedford, LukeCargill, James S.Hughes, WarwickMoore, JonathanStonehouse, SusanneAtkinson, LauraLee, Jack CD.Shah, DivyaOhemeng-Kumi, NatashaRamble, JohnSehmi, JasveenWilliams, RebeccaChatterton, WendyPusok, MonikaEverson, WilliamCastigador, AnibolinaMacnaughton, EmilyEl Bouzidi, KateLampejo, TemiSudhanva, MalurBreen, CassieSluga, GracielaAhmad, Shazaad SY.George, Ryan P.Machin, Nicholas W.Binns, DebbieJames, VictoriaBlacow, RachelCoupland, LindsaySmith, LouiseBarton, EdwardPadgett, DebraScott, GarrenCross, AidanMirfenderesky, MariyamGreenaway, JaneCole, KevinClarke, PhillipDuckworth, NicholaWalsh, SarahBicknell, KellyImpey, RobertWyllie, SarahHopes, RichardBishop, ChloeChalker, VickiHarrison, IanGifford, LauraMolnar, ZoltanAuckland, CressidaEvans, CariadJohnson, KatePartridge, David G.Raza, MohammadBaker, PaulBonner, StephenEssex, SarahMurray, Leanne J.Lawton, Andrew I.Burton-Fanning, ShirellePayne, Brendan AI.Waugh, SheilaGomes, Andrea N.Kimuli, MaimunaMurray, Darren R.Ashfield, PaulaDobie, DonaldAshford, FionaBest, AngusCrawford, LiamCumley, NicolaMayhew, MeganMegram, OliverMirza, JeremyMoles-Garcia, EmmaPercival, BenitaDriscoll, MeganEnsell, LeahLowe, Helen L.Maftei, LaurentiuMondani, MatteoChaloner, Nicola J.Cogger, Benjamin J.Easton, Lisa J.Huckson, HannahLewis, JonathanLowdon, SarahMalone, Cassandra S.Munemo, FlorenceMutingwende, ManasaNicodemi, RobertoPodplomyk FD, OlgaSomassa, ThomasBeggs, AndrewRichter, AlexCormie, ClaireDias, JoanaForrest, SallyHigginson, Ellen E.Maes, MailisYoung, JamieDavidson, Rose K.Jackson, Kathryn A.Keeley, Alexander J.Ball, JonathanByaruhanga, TimothyChappell, Joseph G.Dey, JayasreeHill, Jack D.Park, Emily J.Fanaie, ArezouHilson, Rachel A.Yaze, GeraldineLo, StephanieAfifi, SafiahBeer, RobertMaksimovic, JoshuaMcCluggage, KathrynSpellman, KarlaBresner, CatherineFuller, WilliamMarchbank, AngelaWorkma, TrudyShelest, EkaterinaDebebe, JohnnySang, FeiFrancois, SarahGutierrez, BernardoVasylyeva, Tetyana I.Flaviani, FlaviaRagonnet-Cronin, ManonSmollett, Katherine L.Broos, AliceMair, DanielNichols, JennaNomikou, KyriakiTong, LilyTsatsani, IouliaO'Brien, SarahRushton, StevenSanderson, RoyPerkins, JonCotton, SebGallagher, AbbieAllara, EliasPearson, ClareBibby, DavidDabrer, GavinEllaby, NicholasGallagher, EileenHubb, JonathanLackenby, AngieLee, DavidManesis, NikosMbisa, TamyoPlatt, StevenTwohig, Katherine A.Morgan, MariAydin, AlpBaker, David J.Foster-Nyarko, EbenezerProsolek, Sophie J.Rudder, StevenBaxter, ChrisCarvalho, Sílvia F.Lavin, DeborahMariappan, ArunRadulescu, ClaraSingh, AditiTang, MiaoMorcrette, HelenBayzid, NaduaCotic, MariusBalcazar, Carlos E.Gallagher, Michael D.Maloney, DanielStanton, Thomas D.Williamson, Kathleen A.Manley, RobinMichelsen, Michelle L.Sambles, Christine M.Studholme, David J.Warwick-Dugdale, JoannaEccles, RichardGemmell, MatthewGregory, RichardHughes, MargaretNelson, CharlotteRainbow, LucilleVamos, Edith E.Webster, Hermione J.Whitehead, MarkWierzbicki, ClaudiaAngyal, AdriennGreen, Luke R.Whiteley, MaxBetteridge, EmmaBronner, Iraad F.Farr, Ben W.Goodwin, ScottLensing, Stefanie V.McCarthy, Shane A.Quail, Michael A.Rajan, DianaRedshaw, Nicholas M.Scott, CarolShirley, LesleyThurston, Scott AJ.Rowe, WillGaskin, AmyLe-Viet, ThanhBonfield, JamesLiddle, JennifierWhitwham, Andrew
Journal of Hospital Infection. 135:28-36
Report
Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material
Parfrey P. The clinical epidemiology of contrast-induced nephropathy. Cardiovasc Intervent Radiol. 2005;28 Suppl 2:S3-11. doi: 10.1007/s00270-005-0196-8.
Gleeson TG, Bulugahapitiya S. Contrast-induced nephropathy. AJR Am J Roentgenol. 2004 Dec;183(6):1673-89. doi: 10.2214/ajr.183.6.01831673. No abstract available.
Stacul F. Reducing the risks for contrast-induced nephropathy. Cardiovasc Intervent Radiol. 2005;28 Suppl 2:S12-8. doi: 10.1007/s00270-005-0197-7.
Marenzi G, Assanelli E, Marana I, Lauri G, Campodonico J, Grazi M, De Metrio M, Galli S, Fabbiocchi F, Montorsi P, Veglia F, Bartorelli AL. N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. N Engl J Med. 2006 Jun 29;354(26):2773-82. doi: 10.1056/NEJMoa054209.
Eddleston M, Goddard J, Bateman N. N-acetylcysteine for contrast nephropathy: more clinical science is required. Arch Intern Med. 2006 Aug 14-28;166(15):1668-9; author reply 1669. doi: 10.1001/archinte.166.15.1668-b. No abstract available.
Sandilands EA, Cameron S, Paterson F, Donaldson S, Briody L, Crowe J, Donnelly J, Thompson A, Johnston NR, Mackenzie I, Uren N, Goddard J, Webb DJ, Megson IL, Bateman N, Eddleston M. Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol. BMC Clin Pharmacol. 2012 Feb 3;12:3. doi: 10.1186/1472-6904-12-3.
Report
Biochemical and Functional Biomarkers of Cachexia in Cancer Patients
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011 May;12(5):489-95. doi: 10.1016/S1470-2045(10)70218-7. Epub 2011 Feb 4.
Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998 Apr 15;147(8):755-63. doi: 10.1093/oxfordjournals.aje.a009520.
Mourtzakis M, Prado CM, Lieffers JR, Reiman T, McCargar LJ, Baracos VE. A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care. Appl Physiol Nutr Metab. 2008 Oct;33(5):997-1006. doi: 10.1139/H08-075.
MacDonald AJ, Greig CA, Baracos V. The advantages and limitations of cross-sectional body composition analysis. Curr Opin Support Palliat Care. 2011 Dec;5(4):342-9. doi: 10.1097/SPC.0b013e32834c49eb.
Awad S, Tan BH, Cui H, Bhalla A, Fearon KC, Parsons SL, Catton JA, Lobo DN. Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer. Clin Nutr. 2012 Feb;31(1):74-7. doi: 10.1016/j.clnu.2011.08.008. Epub 2011 Aug 27.
Khal J, Hine AV, Fearon KC, Dejong CH, Tisdale MJ. Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss. Int J Biochem Cell Biol. 2005 Oct;37(10):2196-206. doi: 10.1016/j.biocel.2004.10.017. Epub 2004 Dec 7.
Eley HL, Skipworth RJ, Deans DA, Fearon KC, Tisdale MJ. Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients. Br J Cancer. 2008 Jan 29;98(2):443-9. doi: 10.1038/sj.bjc.6604150. Epub 2007 Dec 18.
Stephens NA, Gallagher IJ, Rooyackers O, Skipworth RJ, Tan BH, Marstrand T, Ross JA, Guttridge DC, Lundell L, Fearon KC, Timmons JA. Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. Genome Med. 2010 Jan 15;2(1):1. doi: 10.1186/gm122.
Johns N, Stephens NA, Preston T. Muscle protein kinetics in cancer cachexia. Curr Opin Support Palliat Care. 2012 Dec;6(4):417-23. doi: 10.1097/SPC.0b013e328359e6dd.
Johns N, Stephens NA, Fearon KC. Muscle wasting in cancer. Int J Biochem Cell Biol. 2013 Oct;45(10):2215-29. doi: 10.1016/j.biocel.2013.05.032. Epub 2013 Jun 11.
Skipworth RJ, Stewart GD, Bhana M, Christie J, Sturgeon CM, Guttridge DC, Cronshaw AD, Fearon KC, Ross JA. Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine. Int J Oncol. 2010 Apr;36(4):973-82. doi: 10.3892/ijo_00000577.
Stephens NA, Skipworth RJ, Fearon KC. Cachexia, survival and the acute phase response. Curr Opin Support Palliat Care. 2008 Dec;2(4):267-74. doi: 10.1097/SPC.0b013e3283186be2.
Tan BH, Fladvad T, Braun TP, Vigano A, Strasser F, Deans DA, Skipworth RJ, Solheim TS, Damaraju S, Ross JA, Kaasa S, Marks DL, Baracos VE, Skorpen F, Fearon KC; European Palliative Care Research Collaborative. P-selectin genotype is associated with the development of cancer cachexia. EMBO Mol Med. 2012 Jun;4(6):462-71. doi: 10.1002/emmm.201200231. Epub 2012 Apr 4.
Brzeszczynska J, Johns N, Schilb A, Degen S, Degen M, Langen R, Schols A, Glass DJ, Roubenoff R, Greig CA, Jacobi C, Fearon KCh, Ross JA. Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly. Aging (Albany NY). 2016 Aug;8(8):1690-702. doi: 10.18632/aging.101006.
Fearon KC. Cancer cachexia and fat-muscle physiology. N Engl J Med. 2011 Aug 11;365(6):565-7. doi: 10.1056/NEJMcibr1106880. No abstract available.
Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, Gorkiewicz G, Tamilarasan KP, Kumari P, Trauner M, Zimmermann R, Vesely P, Haemmerle G, Zechner R, Hoefler G. Adipose triglyceride lipase contributes to cancer-associated cachexia. Science. 2011 Jul 8;333(6039):233-8. doi: 10.1126/science.1198973. Epub 2011 Jun 16.
Mracek T, Stephens NA, Gao D, Bao Y, Ross JA, Ryden M, Arner P, Trayhurn P, Fearon KC, Bing C. Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients. Br J Cancer. 2011 Feb 1;104(3):441-7. doi: 10.1038/sj.bjc.6606083. Epub 2011 Jan 18.
Skipworth RJ, Husi H, Ross JA. How close are we to finding noninvasive markers for upper GI tract cancer? Future Oncol. 2011 Oct;7(10):1121-4. doi: 10.2217/fon.11.90. No abstract available.
Husi H, Barr JB, Skipworth RJ, Stephens NA, Greig CA, Wackerhage H, Barron R, Fearon KC, Ross JA. The Human Urinary Proteome Fingerprint Database UPdb. Int J Proteomics. 2013;2013:760208. doi: 10.1155/2013/760208. Epub 2013 Oct 9.
Husi H, Skipworth RJ, Cronshaw A, Stephens NA, Wackerhage H, Greig C, Fearon KC, Ross JA. Programmed cell death 6 interacting protein (PDCD6IP) and Rabenosyn-5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer. Proteomics Clin Appl. 2015 Jun;9(5-6):586-96. doi: 10.1002/prca.201400111. Epub 2015 May 8.
Deans DA, Tan BH, Wigmore SJ, Ross JA, de Beaux AC, Paterson-Brown S, Fearon KC. The influence of systemic inflammation, dietary intake and stage of disease on rate of weight loss in patients with gastro-oesophageal cancer. Br J Cancer. 2009 Jan 13;100(1):63-9. doi: 10.1038/sj.bjc.6604828.
Deans DA, Wigmore SJ, Gilmour H, Paterson-Brown S, Ross JA, Fearon KC. Elevated tumour interleukin-1beta is associated with systemic inflammation: A marker of reduced survival in gastro-oesophageal cancer. Br J Cancer. 2006 Dec 4;95(11):1568-75. doi: 10.1038/sj.bjc.6603446. Epub 2006 Nov 7.
Deans DA, Tan BH, Ross JA, Rose-Zerilli M, Wigmore SJ, Howell WM, Grimble RF, Fearon KC. Cancer cachexia is associated with the IL10 -1082 gene promoter polymorphism in patients with gastroesophageal malignancy. Am J Clin Nutr. 2009 Apr;89(4):1164-72. doi: 10.3945/ajcn.2008.27025. Epub 2009 Feb 25.
Stewart GD, Skipworth RJ, Pennington CJ, Lowrie AG, Deans DA, Edwards DR, Habib FK, Riddick AC, Fearon KC, Ross JA. Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. Br J Cancer. 2008 Jul 8;99(1):126-32. doi: 10.1038/sj.bjc.6604458.
Stephens NA, Skipworth RJ, Gallagher IJ, Greig CA, Guttridge DC, Ross JA, Fearon KC. Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients. J Cachexia Sarcopenia Muscle. 2015 Mar;6(1):53-61. doi: 10.1002/jcsm.12005. Epub 2015 Mar 31.
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