학술논문

발행년
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(예 : 2010-2015)
'학술논문' 에서 검색결과 140건 | 목록 30~40
Academic Journal
Woestenberg PJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; Care and Public Health Research Institute, Maastricht University Medical Center, Amsterdam, The Netherlands.; King AJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; van Benthem BHB; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; Donken R; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.; Leussink S; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; van der Klis FRM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; de Melker HE; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; van der Sande MAB; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; Julius Center, University Medical Center Utrecht, The Netherlands.; Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.; Hoebe CJPA; Care and Public Health Research Institute, Maastricht University Medical Center, Amsterdam, The Netherlands.; Department of Sexual Health, Infectious Diseases and Environment, South Limburg Public Health Service, Geleen.; Bogaards JA; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Maastricht University Medical Center, Amsterdam, The Netherlands.; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Academic Journal
Sauvageau C; Quebec National Public Health Institute, Canada; Laval University, Canada; CHU de Québec Research Center, Canada. Electronic address: chantal.sauvageau@inspq.qc.ca.; Gilca V; Quebec National Public Health Institute, Canada; Laval University, Canada; CHU de Québec Research Center, Canada.; Donken R; BC Children's Hospital Research Institute, Vaccine Evaluation Center, Canada; University of British Columbia School of Population and Public Health, Canada; Women's Health Research Institute, Canada.; Fan SY; BC Children's Hospital Research Institute, Vaccine Evaluation Center, Canada.; Ogilvie G; University of British Columbia School of Population and Public Health, Canada; Women's Health Research Institute, Canada.; Dobson S; BC Children's Hospital, Canada.
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Academic Journal
Woestenberg PJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands; School of Public Health and Primary Care, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address: petra.woestenberg@rivm.nl.; King AJ; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: audrey.king@rivm.nl.; van der Sande MA; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Julius Center, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: marianne.van.der.sande@rivm.nl.; Donken R; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Department of Pathology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: robine.donken@rivm.nl.; Leussink S; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: suzan.leussink@rivm.nl.; van der Klis FR; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: fiona.van.der.klis@rivm.nl.; Hoebe CJ; School of Public Health and Primary Care, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands; Department of Sexual Health, Infectious Diseases and Environment, South Limburg Public Health Service, P.O. Box 2022, 6160 HA Geleen, The Netherlands. Electronic address: christian.hoebe@ggdzl.nl.; Bogaards JA; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: hans.bogaards@rivm.nl.; van Benthem BH; Center for Infectious Disease Control, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: birgit.van.benthem@rivm.nl.
Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE
Academic Journal
van der Weele P; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.; Vrije Universiteit - University Medical Center (VUmc), Department of Pathology, Amsterdam, the Netherlands.; Breeuwsma M; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.; Donken R; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.; Vrije Universiteit - University Medical Center (VUmc), Department of Pathology, Amsterdam, the Netherlands.; van Logchem E; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.; van Marm-Wattimena N; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.; de Melker H; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.; Meijer CJLM; Vrije Universiteit - University Medical Center (VUmc), Department of Pathology, Amsterdam, the Netherlands.; King AJ; National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, the Netherlands.
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Academic Journal
Schurink-van 't Klooster TM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. Electronic address: tessa.schurink@rivm.nl.; Donken R; Vaccine Evaluation Center, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.; Women's Health Research Institute, BC Women's Hospital + Health Centre, University of British Colombia, Vancouver, BC, Canada.; Schepp RM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.; van der Klis FRM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.; de Melker HE; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Background: A non-inferiority (NI) design aims to demonstrate that the experimental arm is not worse than a comparator within a pre-specified margin. A margin of a risk difference of 10% or a Geometric Mean Titer (GMT) ratio from 1.5 to 2.0 is implicitly recommended for vaccine trials. This study explores which NI margins were used in vaccine studies and how they were determined. Methods: A systematic literature search was performed on February 21st, 2013. This resulted in 260 eligible articles, 148 articles were selected randomly; data was collected by the use of a data extraction form. This thesis had an explorative character and therefore descriptive statistics were used to show the determination of the NI margins and which NI margins were used. Results: From the selected articles, 48 were excluded because they did not met the predefined criteria. In 81/100 articles a NI margin on difference was determined. In 71% of reviewed articles a margin of 10% was used, 19% of the articles stated margins lower than 10% (range 3-7.5%), whereas in 10% of the articles margins larger than 10%(range 11.5-50%) were stated as the NI margin. In 55/100 articles a NI margin on the GMT ratio was stated. In 60% of the articles a margin of 0.67/1.5 was used, in 33% the stated margins were 0.5/2.0. A large amount (85%) of the examined articles did not discuss how the NI margin was determined. Only five articles referred to the FDA or EMA guidelines, eight articles referred to methodological articles and two articles referred to previous articles specific for the vaccine. In 82/100 articles the conclusion corresponded to the results, in fourteen the conclusion could not be checked because the effect estimates were not shown, in four articles the conclusion of the authors was not in line with the results. Conclusion: The majority of reviewed articles showed no determination of the NI margin. Not all articles showed all their estimates on NI. Reporting on design and results of NI vaccine t
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[검색어] Donken, R.
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