부산대학교 도서관

Investigation of the inhibitory fraction of Leucas asperaon prostaglandin-induced contraction in guinea pig ileum provided four new diterpenes, leucasperones A (1) and B (2) and leucasperols A (3) and B (4), and three new isopimarane glycosides, leucasperosides A, B, and C (5−7), together with the known compounds asperphenamate, maslinic acid, (−)-isololiolide, and linifolioside. The structures of the compounds were determined by detailed spectroscopic analysis. The configurations of 1 and2and the acetylated derivatives of 3and 4were determined by differential NOE analysis and CD data. Leucasperone A (1), leucasperosides A (5) and B (6), and linifolioside showed inhibition of prostaglandin-induced contractions.