학술논문
Intravitreal aflibercept 8 mg in diabetic macular oedema (PHOTON): 48-week results from a randomised, double-masked, non-inferiority, phase 2/3 trial
Document Type
Article
Author
Brown, David M; Boyer, David S; Do, Diana V; Wykoff, Charles C; Sakamoto, Taiji; Win, Peter; Joshi, Sunir; Salehi-Had, Hani; Seres, András; Berliner, Alyson J; Leal, Sergio; Vitti, Robert; Chu, Karen W; Reed, Kimberly; Rao, Rohini; Cheng, Yenchieh; Sun, Wei; Voronca, Delia; Bhore, Rafia; Schmidt-Ott, Ursula; Schmelter, Thomas; Schulze, Andrea; Zhang, Xin; Hirshberg, Boaz; Yancopoulos, George D; Sivaprasad, Sobha; Abraham, Prema; Aderman, Christopher; Akiyama, Kunihiko; Alfaro, Daniel V.; Ali, Fareed A.; Amini, Payam; Anzalotta, Andres Emanuelli; Bátor, György; Batlle, Ivan; Berger, Adam; Bhandari, Ramanath; Bridges, William; Brinkmann, Christian; Brown, Jamin; Burgess, Stuart; Calzada, Jorge; Capone Jr., Antonio; Cervena, Dana; Charles, Steven; Chaudhry, Nauman; Chow, David; Clark, W. Lloyd; Conrad III, Paul; Cunningham, Matthew; Dadgostar, Hajir; Dessouki, Amr; Deupree, Dana; Devine, Christopher; Eichenbaum, David; Ernest, Jan; Feltgen, Nicolas; Fenberg, Moss; Ferrone, Philip; Frenkel, Ronald; Friedman, Scott; Gasperini, Julie; Gerstenblith, Adam; Ghorayeb, Ghassan; Giunta, Michel; Goff, Mitchell; Golas, Liliya; Googe Jr., Joseph M.; Goren Fein, Jordana; Hagedorn, Curtis; Hagiwara, Akira; Hahn, Paul; Hairston, Richard; Handza, Jason; Hau, Vivienne; Hayashi, Ken; Heier, Jeffrey; Hershberger, Vrinda; Higgins, Patrick; Hirano, Yoshio; Honda, Shigeru; Ikegami, Yasuko; Ishida, Yuichiro; Ishikawa, Isao; Ishii, Kiyoshi; Jablon, Eric P.; Jain, Atul; Kaji, Yuichi; Kapoor, Kapil; Kerényi, Ágnes; Kimura, Kazuhiro; Kishino, Genichiro; Kiss, Katalin; Kitaoka, Takashi; Klancnik, James M.; Kobayashi, Namie; Kogo, Jiro; Korda, Vladimir; Kruger, Erik; Kusuhara, Sentaro; Lara, Wilfredo; Laud, Ketan; Lee, Seong; Luu, James; Marcus, Dennis; Mein, Calvin; Meleth, Annal; Milibák, Tibor; Mitamura, Yoshinori; Murata, Toshinori; Noge, Sumiyo; Onoe, Hajime; Osher, James; Papp, András; Parschauer, Justin; Patel, Sugat; Patel, Sunil; Pezda, Matthew; Pirouz, Ashkan; Prasad, Pradeep; Punjabi, Omar; Rao, Llewelyn; Roe, Richard; Schadlu, Ramin; Schneider, Eric; Shah, Ankur; Shah, Milan; Shah, Sandeep; Shah, Sumit; Sharma, Ashish; Sheth, Veeral; Shimura, Masahiko; Singerman, Lawrence; Spital, Georg; Stoltz, Robert; Suan, Eric; Suzuma, Kiyoshi; Takahashi, Hidenori; Takamura, Yoshihiro; Takeuchi, Masaru; Tan, Jeffrey; Thomas, Benjamin; Tóth, Edit; -Molnár; Ueda, Tetsuo; Ushida, Hiroaki; Vajas, Attila; Varma, Deepali; Varsányi, Balázs; Veith, Miroslav; Weber, Pamela; Wee, Raymond; Williams, Geoff; Yamada, Haruhiko; Yonekawa, Yoshihiro; Yoshida, Shigeo
Source
The Lancet; March 2024, Vol. 403 Issue: 10432 p1153-1163, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
A high-dose formulation of intravitreal aflibercept (8 mg) could improve treatment outcomes in diabetic macular oedema (DMO) by requiring fewer injections than the standard comparator, aflibercept 2 mg. We report efficacy and safety results of aflibercept 8 mg versus 2 mg in patients with DMO.