학술논문
Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study
Document Type
Article
Author
Schlapbach, Luregn J; Ganesamoorthy, Devika; Wilson, Clare; Raman, Sainath; George, Shane; Snelling, Peter J; Phillips, Natalie; Irwin, Adam; Sharp, Natalie; Le Marsney, Renate; Chavan, Arjun; Hempenstall, Allison; Bialasiewicz, Seweryn; MacDonald, Anna D; Grimwood, Keith; Kling, Jessica C; McPherson, Stephen J; Blumenthal, Antje; Kaforou, Myrsini; Levin, Michael; Herberg, Jethro A; Gibbons, Kristen S; Coin, Lachlan J M; Levin, Michael; Coin, Lachlan; Gormley, Stuart; Hamilton, Shea; Hoggart, Clive; Kaforou, Myrsini; Sancho-Shimizu, Vanessa; Wright, Victoria; Abdulla, Amina; Agapow, Paul; Bartlett, Maeve; Eleftherohorinou, Hariklia; Galassini, Rachel; Inwald, David; Mashbat, Meg; Menikou, Stephanie; Mustafa, Sobia; Nadel, Simon; Rahman, Rahmeen; Shailes, Hannah; Thakker, Clare; Bokhandi, S.; Power, Sue; Barham, Heather; Pathan, N.; Ridout, Jenna; White, Deborah; Thurston, Sarah; Faust, S.; Patel, S.; McCorkell, Jenni; Davies, P.; Crate, Lindsey; Navarra, Helen; Carter, Stephanie; Ramaiah, R.; Patel, Rekha; Tuffrey, Catherine; Gribbin, Andrew; McCready, Sharon; Peters, Mark; Hardy, Katie; Standing, Fran; O'Neill, Lauren; Abelake, Eugenia; Deep, Akash; Nsirim, Eniola; Pollard, Andrew; Willis, Louise; Young, Zoe; Royad, C.; White, Sonia; Fortune, Peter-Marc; Hudnott, Phil; Martinón-Torres, Federico; Salas, Antonio; Álvez González, Fernando; Barral-Arca, Ruth; Cebey-López, Miriam; Curras-Tuala, María José; García, Natalia; García Vicente, Luisa; Gómez-Carballa, Alberto; Gómez Rial, Jose; Grela Beiroa, Andrea; Justicia Grande, Antonio; Leboráns Iglesias, Pilar; Martínez Santos, Alba Elena; Martinón-Torres, Nazareth; Martinón Sánchez, José María; Morillo Gutiérrez, Beatriz; Mosquera Pérez, Belén; Obando Pacheco, Pablo; Pardo-Seco, Jacobo; Pischedda, Sara; Rivero-Calle, Irene; Rodríguez-Tenreiro, Carmen; Redondo-Collazo, Lorenzo; Salas Ellacuriaga, Antonio; Fernández, Sonia Serén; del Sol Porto Silva, María; Vega, Ana; Vilanova Trillo, Lucía; Reyes, Susana Beatriz; Cruz León León, María; Navarro Mingorance, Álvaro; Gabaldó Barrio, Xavier; Oñate Vergara, Eider; Concha Torre, Andrés; Vivanco, Ana; Fernández, Reyes; Giménez Sánchez, Francisco; Sánchez Forte, Miguel; Rojo, Pablo; Contreras, J. Ruiz; Palacios, Alba; Epalza Ibarrondo, Cristina; Fernández Cooke, Elizabeth; Navarro, Marisa; Álvarez Álvarez, Cristina; José Lozano, María; Carreras, Eduardo; Brió Sanagustín, Sonia; Neth, Olaf; Martínez Padilla, Mª del Carmen; Prieto Tato, Luis Manuel; Guillén, Sara; Fernández Silveira, Laura; Moreno, David; de Groot, R.; Tutu van Furth, A.M.; van der Flier, M.; Boeddha, N.P.; Driessen, G.J.A.; Emonts, M.; Hazelzet, J.A.; Kuijpers, T.W.; Pajkrt, D.; Sanders, E.A.M.; van de Beek, D.; van der Ende, A.; Philipsen, H.L.A.; Adeel, A.O.A.; Breukels, M.A.; Brinkman, D.M.C.; de Korte, C.C.M.M.; de Vries, E.; de Waal, W.J.; Dekkers, R.; Dings-Lammertink, A.; Doedens, R.A.; Donker, A.E.; Dousma, M.; Faber, T.E.; Gerrits, G.P.J.M.; Gerver, J.A.M.; Heidema, J.; Homan-van der Veen, J.; Jacobs, M.A.M.; Jansen, N.J.G.; Kawczynski, P.; Klucovska, K.; Kneyber, M.C.J.; Koopman-Keemink, Y.; Langenhorst, V.J.; Leusink, J.; Loza, B.F.; Merth, I.T.; Miedema, C.J.; Neeleman, C.; Noordzij, J.G.; Obihara, C.C.; van Overbeek- van Gils, A.L.T.; Poortman, G.H.; Potgieter, S.T.; Potjewijd, J.; Rosias, P.P.R.; Sprong, T.; ten Tussher, G.W.; Thio, B.J.; Tramper-Stranders, G.A.; van Deuren, M.; van der Meer, H.; van Kuppevelt, A.J.M.; van Wermeskerken, A.M.; Verwijs, W.A.; Wolfs, T.F.W.; Schlapbach, Luregn J.; Agyeman, Philipp; Aebi, Christoph; Giannoni, Eric; Stocker, Martin; Posfay-Barbe, Klara M.; Heininger, Ulrich; Bernhard-Stirnemann, Sara; Niederer-Loher, Anita; Kahlert, Christian; Hasters, Paul; Relly, Christa; Baer, Walter; Berger, Christoph; Carrol, Enitan D.; Paulus, Stéphane; Frederick, Hannah; Jennings, Rebecca; Johnston, Joanne; Kenwright, Rhian; Fink, Colin G; Pinnock, Elli; Emonts, Marieke; Agbeko, Rachel; Anderson, Suzanne; Secka, Fatou; Bojang, Kalifa; Sarr, Isatou; Kebbeh, Ngange; Sey, Gibbi; Saidykhan, Momodou; Cole, Fatoumata; Thomas, Gilleh; Antonio, Martin; Zenz, Werner; Kohlfürst, Daniela S.; Binder, Alexander; Schweintzger, Nina A.; Sagmeister, Manfred; Baumgart, Hinrich; Baumgartner, Markus; Behrends, Uta; Biebl, Ariane; Birnbacher, Robert; Blanke, Jan-Gerd; Boelke, Carsten; Breuling, Kai; Brunner, Jürgen; Buller, Maria; Dahlem, Peter; Dietrich, Beate; Eber, Ernst; Elias, Johannes; Emhofer, Josef; Etschmaier, Rosa; Farr, Sebastian; Girtler, Ylenia; Grigorow, Irina; Heimann, Konrad; Ihm, Ulrike; Jaros, Zdenek; Kalhoff, Hermann; Kaulfersch, Wilhelm; Kemen, Christoph; Klocker, Nina; Köster, Bernhard; Kohlmaier, Benno; Komini, Eleni; Kramer, Lydia; Neubert, Antje; Ortner, Daniel; Pescollderungg, Lydia; Pfurtscheller, Klaus; Reiter, Karl; Ristic, Goran; Rödl, Siegfried; Sellner, Andrea; Sonnleitner, Astrid; Sperl, Matthias; Stelzl, Wolfgang; Till, Holger; Trobisch, Andreas; Vierzig, Anne; Vogel, Ulrich; Weingarten, Christina; Welke, Stefanie; Wimmer, Andreas; Wintergerst, Uwe; Wüller, Daniel; Zaunschirm, Andrew; Ziuraite, Ieva; Žukovskaja, Veslava; Hibberd, Martin L.; Davila, Sonia; Delany, Isabel; Schlapbach, Luregn J; Raman, Sainath; Sharp, Nathalie; Phillips, Natalie; Irwin, Adam; Balch, Ross; Harley, Amanda; Johnson, Kerry; Sever, Zoe; George, Shane; Grimwood, Keith; Snelling, Peter J; Chavan, Arjun; Kitcatt, Eleanor; Lawton, Luke; Hempenstall, Allison; Pilot, Pelista; Gibbons, Kristen S; Le Marsney, Renate; Blumenthal, Antje; Ganesamoorthy, Devika; Pardo, Carolyn; Kling, Jessica; McPherson, Stephen; MacDonald, Anna D; Bialasiewicz, Seweryn; Pham, Trang; Coin, Lachlan
Source
The Lancet Child & Adolescent Health; May 2024, Vol. 8 Issue: 5 p325-338, 14p
Subject
Language
ISSN
23524642; 23524650
Abstract
Sepsis is defined as dysregulated host response to infection that leads to life-threatening organ dysfunction. Biomarkers characterising the dysregulated host response in sepsis are lacking. We aimed to develop host gene expression signatures to predict organ dysfunction in children with bacterial or viral infection.