학술논문
Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
Document Type
Article
Author
Datoo, Mehreen S; Dicko, Alassane; Tinto, Halidou; Ouédraogo, Jean-Bosco; Hamaluba, Mainga; Olotu, Ally; Beaumont, Emma; Ramos Lopez, Fernando; Natama, Hamtandi Magloire; Weston, Sophie; Chemba, Mwajuma; Compaore, Yves Daniel; Issiaka, Djibrilla; Salou, Diallo; Some, Athanase M; Omenda, Sharon; Lawrie, Alison; Bejon, Philip; Rao, Harish; Chandramohan, Daniel; Roberts, Rachel; Bharati, Sandesh; Stockdale, Lisa; Gairola, Sunil; Greenwood, Brian M; Ewer, Katie J; Bradley, John; Kulkarni, Prasad S; Shaligram, Umesh; Hill, Adrian V S; Mahamar, Almahamoudou; Sanogo, Koualy; Sidibe, Youssoufa; Diarra, Kalifa; Samassekou, Mamoudou; Attaher, Oumar; Tapily, Amadou; Diallo, Makonon; Dicko, Oumar Mohamed; Kaya, Mahamadou; Maguiraga, Seydina Oumar; Sankare, Yaya; Yalcouye, Hama; Diarra, Soumaila; Niambele, Sidi Mohamed; Thera, Ismaila; Sagara, Issaka; Sylla, Mala; Dolo, Amagana; Misidai, Nsajigwa; Simando, Sylvester; Msami, Hania; Juma, Omary; Gutapaka, Nicolaus; Paul, Rose; Mswata, Sarah; Sasamalo, Ibrahim; Johaness, Kasmir; Sultan, Mwantumu; Alexander, Annastazia; Kimaro, Isaac; Lwanga, Kauye; Mtungwe, Mwajuma; Khamis, Kassim; Rugarabam, Lighton; Kalinga, Wilmina; Mohammed, Mohammed; Kamange, Janeth; Msangi, Jubilate; Mwaijande, Batuli; Mtaka, Ivanny; Mhapa, Matilda; Mlaganile, Tarsis; Mbaga, Thabit; Yerbanga, Rakiswende Serge; Samtouma, Wendkouni; Sienou, Abdoul Aziz; Kabre, Zachari; Ouedraogo, Wendinpui Jedida Muriel; Yarbanga, G Armel Bienvenu; Zongo, Issaka; Savadogo, Hamade; Sanon, Joseph; Compaore, Judicael; Kere, Idrissa; Yoni, Ferdinand Lionel; Sanre, Tewende Martine; Ouattara, Seydou Bienvenu; Provstgaard-Morys, Samuel; Woods, Danielle; Snow, Robert W.; Amek, Nyaguara; Ngetsa, Caroline J.; Ochola-Oyier, Lynette Isabella; Musyoki, Jennifer; Munene, Marianne; Mumba, Noni; Adetifa, Uche Jane; Muiruri, Charles Mwangi; Mwawaka, Jimmy Shangala; Mwaganyuma, Mwatasa Hussein; Ndichu, Martha Njeri; Weya, Joseph Ochieng; Njogu, Kelvin; Grant, Jane; Webster, Jayne; Lakhkar, Anand; Ido, N. Félix André; Traore, Ousmane; Tahita, Marc Christian; Bonko, Massa dit Achille; Rouamba, Toussaint; Ouedraogo, D. Florence; Soma, Rachidatou; Millogo, Aida; Ouedraogo, Edouard; Sorgho, Faizatou; Konate, Fabé; Valea, Innocent
Source
The Lancet; February 2024, Vol. 403 Issue: 10426 p533-544, 12p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Recently, we found that a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical malaria with seasonal administration in a phase 2b trial in Burkina Faso. Here, we report on safety and efficacy of the vaccine in a phase 3 trial enrolling over 4800 children across four countries followed for up to 18 months at seasonal sites and 12 months at standard sites.