학술논문
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
Document Type
Article
Author
Rovin, Brad H; Barratt, Jonathan; Heerspink, Hiddo J L; Alpers, Charles E; Bieler, Stewart; Chae, Dong-Wan; Diva, Ulysses A; Floege, Jürgen; Gesualdo, Loreto; Inrig, Jula K; Kohan, Donald E; Komers, Radko; Kooienga, Laura Ann; Lafayette, Richard; Maes, Bart; Małecki, Robert; Mercer, Alex; Noronha, Irene L; Oh, Se Won; Peh, Chen Au; Praga, Manuel; Preciado, Priscila; Radhakrishnan, Jai; Rheault, Michelle N; Rote, William E; Tang, Sydney C W; Tesar, Vladimir; Trachtman, Howard; Trimarchi, Hernán; Tumlin, James A; Wong, Muh Geot; Perkovic, Vlado; Abbasciano, Isabella; Abrantes, Catarina; Accarino, Simone; Adler, Sharon; Adoberg, Annika; Afsari, Rouzbeh; Ahmad, Syeda; Ahmed, Jafar; Ahn, Wooin; Ajayi, Bamidele; Aksamit, Dariusz; Al Chalabi, Saif; Alamartine, Eric; Alchi, Bassam; Ali, Mohammad; Aliotta, Roberta; Almaani, Salem; Almeida, Catarina; Almeida, Edgar; Alvarez, Francisco de la Prada; Alves, Patricia; Annese, Francesca; Appel, Gerald; Arduan, Alberto Ortiz; Arena, Maria; Arevalo, Marta Calvo; Arfaania, Dariush; Arias, Carlos; Aristoy, Emma Calatayud; Asakiene, Egle; Ashley, Sarah; Assefi, Ali; Atenza, Alba; Auerbach, Asta; Augustyniak-Bartosik, Hanna; Avella, Monroy; Ayling-Smith, Jonathan; Ayoub, Isabelle; Ayvazyan, Christine; Baccaro, Rocco; Bailey, Asha; Baker, Bruce; Balamuthusamy, Saravanan; Ballarin, Jose; Barata, Rui; Barbic, Jerko; Barisic, Dunja; Barratt, Jonathan; Barreto, Jose Carlos de Jesus; Barrios, Clara; Belingheri, Mirco; Benesova, Anna; Bernabeu, Ana Avila; Bernhardt, Wanja; Bhadra, Shamik; Biancone, Luigi; Blanchard, Anne; Boaglio, Elena; Bolignano, Davide; Bomback, Andrew; Bonilla, Gustavo Andres Useche; Bordoli, Monica; Bose, Bhadran; Boudville, Neil; Brandon, Donald; Brandon, Donald; Brown, Karen; Broyet, Christian; Bucknall, Thomas; Buffet, Alexandre; Bumblyte', Inga Arune; Burdese, Manuel; Burgos, Natalia Allende; Burgos, Natalia Allende; Burguet, Laure; Burtey, Stephane; Busch, Martin; Cakiroglu, Figen; Campbell, Victoria; Canetta, Pietro; Capaccio, Flavia; Carbonell, Juan; Cardoso, Filipa; Carro, Clara Garcia; Carroll, Robert; Carron, Pierre-Louis; Carullo, Nazareno; Cassia, Matthias; Caster, Dawn; Castillo, Belen Vizcaino; Catucci, Davide; Cavalli, Andrea; Chae, Dong-Wan; Chakera, Aron; Chan, Doris; Chan, Gary Chi Wang; Chan, Anthony Ting Pong; Chan, Lai Wan; Chang, Jae Hyun; Chang, Ming-Shan; Chapman, Fiona; Charytan, Chaim; Chaudhry, Asghar; Cheetham, Melissa; Chen, Cheng-Hsu; Chen, Hsin-Yu; Chen, Chien-Liang; Chen, Hung-Yuan; Chen, Hung-Chun; Chenine, Leila; Cheung, Siu Fai; Cheung, Chee Kay; Chiche-Jourde, Noemie; Chiu, Hsien-Fu; Chiu, Yen-Ling; Chiu, Yi-Wen; Chiu, Ian; Choi, Hoon Young; Chou, Kang-Ju; Chowdhury, Paramit; Chowdhury, Pradip; Chrysochou, Constantina; Chukwu, Chukwuma; Chun, Ka Yeong; Chung, Wookyung; Cieniawski, Dominik; Claisse, Guillaume; Clayton, Philip; Cleary, Catalina Martín; Clement, Nisha; Coates, Toby; Cogno, Chiara; Colla, Loredana; Collins, Michael; Colucci, Marco; Combe, Christian; Comi, Nicolino; Comunale, Roderick; Contreras, Gabriel; Cooper, Bruce; Coppock, Gaia; Costa, Ana Cortesão; Costanzi, Stefano; Cozzolino, Mario; Crail, Susan; Cunha, Liliana; Curry, Elizabeth; Dai, Tiane; Daina, Erica; Daneshvari, Sam; Dasgupta, Indranil; DaSilva, Louise; Davidson, Robert; De Bhailis, Aine Maire; de Précigout, Valérie; Decupere, Marc; Delmas, Yahsou; Deodato, Francesca; Dhaun, Neeraj; Dhaygude, Ajay; Dhelaria, Ranjit; Di Maio, Federica; Diezhandino, Maria Angeles Goicoechea; Dika, Zivka; Dinic, Miriana; Dittmer, Ian; Dobre, Mirela; Doctor, Gabriel; Donati, Gabriele; Doubel, Peter; Douthit, Nicole; Draganova, Diliana; Drexler, Yelena; Drinkovic, Martin; Drinovska, Klara; Dudreuilh, Caroline; Dumond, Clement; Durlen, Ivan; Dussol, Bertrand; Encarnacion, Montserrat Diaz; Endre, Zoltan; Enrique, Jorge; Eqbal, Yusuf; Erlich, Jonathan; Esposito, Vittoria; Esposito, Ciro; Fakih, Faisal; Fang, Hua-Chang; Farinha, Ana; Fearday, Aaron; Felgueiras, Joana de Sousa Soares; Felicjanczuk, Elzbieta; Fernandes, João Carlos; Fernandes, Sara; Fernandes, Adriana; Fernandez, Jose Luño; Fernandez, Victor; Fernando, Mangalee; Figueiredo, Ana Carolina; Firre, Eric; Floege, Jürgen; Flossmann, Oliver; Floyd, Lauren; Fonseca, Nuno; Fonseca, Jose Nuno de Almeida Agapito; Foote, Celine; Forbes, Suzanne; Forcen, Angel; Fornoni, Alessia; Fouassier, David; Fraser, Ian; Fung, Ka Shun Samuel; Furlano, Monica; Furtado, Teresa; Gadh, Rajdeep; Gaisset, Roxane; Gallagher, Martin; Gameiro, Joana; Gangadharan, Muralikrishna; Garcia, Fabiola Alonso; Garcia, Olga Gracia; Garg, Gunjan; Garrouste, Cyril; Gautam, Archana; Geara, Abdallah; Geddes, Colin; Gellineo, Lana; Germain, Michael; Gesualdo, Loreto; Ghalli, Farid; Giaroni, Francesco; Giles, Harold; Gillies, Alastair; Gimeno, Ana Vilar; Girardet, Annette; Glaze, Jeffrey; Goh, Tze; Gois, Mario; Goldsmith, Christopher; Goma, Elena; Gomes, Ana Marta; Goncalves, Luis Pedro Falcao; Goncalves, Sara; Gontarek-Kacprzak, Julita; Gonzalez, Carlos; Gopu, Arun; Gowda, Nayan; Gray, Nicholas; Greco, Barbara; Green, Heather; Greze, Clarisse; Griffin, Sian; Guldris, Secundino Cigarran; Guzman, Ursula Verdalles; Ha, Jeffrey Tsun Kit; Hall, Amanda; Hamilton, Patrick; Han, Seung Hyeok; Haws, Robert; Hayat, Ashik; Heath, Lauren; Heinrichs, Sven; Henderson, Andrew; Henderson, Amy; Hendren, Elizabeth; Heng, Anne-Elisabeth; Heres, Salia Virxinia Pol; Herfurth, Johann Konstantin; Herrero, Evangelina Merida; Ho, Tzung-Yo; Hogan, Jonathan; Hohenstein, Bernd; Hollett, Peter; Horvatic, Ivica; Hsu, Bang-Gee; Hsu, Chia-Tien; Hsu, Chih-Yang; Hsu, Shih-Ping; Huang, Chien-Wei; Hudson, Amy; Hung, Chi-Chih; Hwang, Shang-Jyh; Hwang, Daw-Yang; Hyun, Young Youl; Ilmoja, Madis; Irish, Georgina; Jacob, Radu; Jahan, Sadia; Jain, Arunima; Jamar, Sofie; Jander, Anna; Jang, Hye Ryoun; Janko, Catherine; Jardine, Meg; Jaskowski, Piotr; Jeantet, Guillaume; Jelakovic, Bojan; Jeon, Junseok; Jeong, Jong Cheol; Jesudason, Shilpanjali; Jittirat, Arksarapuk; Jo, Sang-Kyung; Jones, Rachel; Joo, Narae; Jorge, Sofia; Julian, Bruce; Jung, JiYong; Jyothinagaram, Praveena; Kadakia, Jigar; Kamal, Fahameedah; Kanigicherla, Durga; Karanovic, Sandra; Karras, Alexandre; Kasimatis, Theodoros; Kassem, Mohamad; Kattamanchi, Siddhartha; Keller, Christopher; Kentric, Dubravka Trajbar; Kettner, Christiane; Khalil, Kassem; Kim, Dana; Kim, Se Joong; Kim, Yeong Hoon; Kim, Yunmi; Kim, Hyung Wook; Kim, Sunggyun; Kim, Jwa-Kyung; Kim, Aejin; Kim, Myung-Gyu; Kimber, Cassandra; Klamm, Kathryn; Koch, Annegret; Koester, Eric; Kolvald, Kulli; Kon, Sui; Kooienga, Laura Ann; Kotwal, Sradha; Krajewska, Magdalena; Kratka, Karolina; Krishnan, Anoushka; Krishnasamy, Rathika; Krueger, Thilo; Kruljac, Ivan; Kulka, Simone; Kunzendorf, Ulrich; Kuo, Mei-Chuan; Kuo, Hung-Tien; Kuo, Sheng; Kwan, Lorraine Pui Yuen; Kwella, Norbert; Kwella, Bogna; Kyaw, Kay; Labat, Aurore; Lafayette, Richard; Lagatta, Mark; Lam, Chi Kwan Darwin; Lambie, Mark; Lanaret, Camille; Latif, Farah; Laute, Margo; Law, Wai Ping; Lawman, Sarah; Lazo, Mercedes Salgueira; Lee, Hajeong; Lee, Moon Hyoung; Lee, Kyu-Beck; Lee, Hyung-seok; Lee, JungEun; Lee, Hyun Hee; Lee, Po-Tsang; Leis, Liisi; Lemahieu, Wim; Leung, Janson; Li, Yan; Lie, Davina Ngoi Wah; Lifland, Howard; Lilienthal, Kadri; Lim, Wai; Limardo, Monica; Livrozet, Marine; Longhi, Selena; Lopes, Daniela; Lopes, Jose Antonio; Lorde, Nathan; Luxton, Grant; Ma, Mingyao; Madhrira, Machaiah; Madonia, Phillip; Maes, Bart; Mahadevan, Kumaradevan; Mahdi, Amar; Mahdi, Eamon; Maillard, Nicolas; Maixnerova, Dita; Majstorovic Barac, Karolina; Malecki, Robert; Malfait, Thomas; Malvica, Silvia; Mandayam, Sreedhar; Manley, Paul; Mansfield, Nick; Marcantoni, Carmelita; Mariat, Christophe; Marin, Tamara Malek; Marin, Lida Maria Rodas; Mark, Patrick; Marques, Joana; Martinez, Eduardo Gutierrez; Martinez, Stacy; Masset, Catherine; Masson, Ingrid; Mather, Amanda; Maung Myint, Thida Maung; Mayet, Valentin; McCafferty, Kieran; McCarthy, Ellen; McDonald, Stephen; McGreal, Kerri; McMahon, Kellyn; McNally, Andrew; McQuarrie, Emily; Medina, Allyson; Meeus, Gert; Mehta, Kshama; Mendoza, Elder; Menezes, Maria; Meng, Jerry; Messa, Piergiorgio; Messias, Ana; Miarka, Przemyslaw; Miglinas, Marius; Mikacic, Ivana; Mikhail, Ashraf; Milicevic, Martina; Minasian, Raffi; Moeller, Marcus; Mohey, Hesham; Mojarrab, Javad; Mok, Maggie Ming Yee; Moncasi, Eduardo Parra; Moonen, Martial; Morales, Wenceslao Adrian Aguilera; Moreno, Eduardo Verde; Moreno, Antolina; Morris, Adam; Moutzouris, Dimitrios; Moya, Mercedes Gonzalez; Mucha, Simon; Musolino, Michela; Napodano, Pietro; Natario, Ana; Negrea, Lavinia; Nelson, Bradley; Neuen, Brendon; Newsome, Britt; Ng, Kit Chung Jack; Nguyen, Thu; Nguyen, Viet; Nicolo, Clementine; Nitschke, Martin; Noble, Euan; Noble, Euan; Nolasco, Fernando; O'Lone, Emma; Ochoa, Adriana Sierra; Oh, Kook-Hwan; Oh, SeWon; Okoh, Pedro; Ombelet, Sara; O'Shaughnessy, Michelle; Ou, Shih-Hsiang; Packham, David; Padiyar, Aparna; Pai, Mei-Fen; Pamplona, Irene Agraz; Pan, Szu-Yu; Pandya, Bhavna; Papadia, Federica; Pardinhas, Clara; Parikh, Nishita; Parikh, Samir; Park, Hyeong Cheon; Park, Jung Tak; Parreira, Lucia; Passerini, Patrizia; Patak, Ramachandra; Patecki, Margret; Patel, Rajan; Patel, Jusmin; Patel Suthar, Meera; Patella, Gemma; Patrikyan, Artashes; Pavlovic, Drasko; Paxton, William; Peh, Chen; Peleg, Yonatan; Pelicano, Josep Miquel Blasco; Peng, Yu-Sen; Pereira de Vicente, Manuel; Perez, Jonay Pantoja; Perez, Erika; Perez de Jose, Ana; Pérez Gómez, María Vanessa; Perez Lluna, Leticia; Peri, Usha; Perico, Norberto; Philipponnet, Carole; Phua, Elaine; Piel, Julia; Pillai, Unnikrishnan; Pilmore, Helen; Plavljanic, Djuro; Plaza, Mercedes Velo; Pollock, Carol; Ponnusamy, Arvind; Ponti, Serena; Powell, Thomas; Pradhan, Nishigandha; Prado, Raul Fernandez; Prkacin, Ingrid; Pruthi, Rishi; Pugh, Dan; Quinn, Sarah; Quintana, Luis F; Raakesh, Lathika; Rabindranath, Kannaiyan; Radermacher, Luc; Radhakrishnan, Jai; Ragy, Omar Sherin Ibrahim; Raichoudhury, Ritesh; Raimundo, Mario; Randone, Paolo; Razavian, Mona; Reichel, Helmut; Reis, Marina; Remuzzi, Giuseppe; Reynolds, Annie; Ricchiuto, Anna; Rico, Ivon Maritza Bobadilla; Rigothier, Claire; Ritchie, Angus; Rivero, Maria Antonieta Azancot; Rizk, Dana; Ro, Han; Rodriguez, Alfred; Rodriguez Garcia, Eva; Roger, Simon; Rony, Mohammad; Rosenberg, Mai; Roueff, Stephane; Rovin, Brad; Roxburgh, Sarah; Ruiz, Mario; Rusinol, Helena Marco; Rychlik, Ivan; Sá, Helena; Salehi, Tania; Sánchez de la Nieta, Maria Dolores; Sanden, Silja; Santockiene, Lina; Santos, Patricia Valerio; Santos, Iara Da Silva; Sargsyan, Mari; Sarnow, Franziska; Sat, Sebahat; Satora, Ewa; Savuk, Ana; Sayer, Matthew; Schlieper, Georg; Schlosser, Mandy; Schmidt-Guertler, Hans; Schockaert, Olivier; Schulte, Kevin; Schulz, Lisa; Selvaskandan, Haresh; Semple, David; Sen, Shaundeep; Seppet, Elviira; Serrano, Antonio Galan; Serre, Jean-Emmanuel; Sevillano, Angel; Shah, Sapna; Shen, Yvonne; Sheridan, Brittany; Shu, Kai-Hsiang; Sightler, Ford; Silva, Sónia; Silva, Arnold; Sinha, Smeeta; Siriwardana, Amanda; Sitas, Zvonimir; Sivo, Carmen; Sizeland, Peter; Sly, Cathylee; Smith, Priscilla; Snow, Brian; Soares, Elsa Sofia Quadrado; Solazzo, Andrea; Solis, Elena Gutierrez; Solomon, Laurence; Song, Young Rim; Sousa, Helena; Spinowitz, Bruce; Stallworthy, Elizabeth; Stamellou, Eleni; Stanczyk, Malgorzata; Stangenberg, Stefanie; Stankovic, Marija; Stankuviene, Asta; Stea, Emma Diletta; Stompor, Tomasz; Storrar, Joshua; Sullivan, James; Sulowicz, Wladyslaw; Suyumova, Irina; Szeto, Cheuk Chun; Tamarit, Esther; Tan, Eddie; Tan, May; Tang, Sydney Chi Wai; Tang, Hon; Teixeira, Catarina; Telling, Kadri; Terrades, Natalia Ramos; Tesar, Vladimir; Tez, Didem; Thervet, Eric; Thibaudin, Damien; Thomas, Mark; Thyagarajan, Nikhil; Tkaczyk, Marcin; Torreggiani, Massimo; Trillini, Matias; Tsai, Shang-Feng; Tsai, Wan-Chuan; Tsai, Jer-Chia; Tseng, Po-Yu; Tumlin, James; Tung, Kuei-Ting; Turnbull, Angus; Udani, Suneel; Uhlinova, Jana; Unt, Kristin; Urciuolo, Federica; Vanacker, An; Vandewiele, Bert; Vaz, Alvaro; Veermae, Kristi; Viaene, Liesbeth; Vickiene, Alvita; Vigano, Sara; Vila, Maria Antonia Munar; Vilayur, Eswari; Villanueva, Caridad Martinez; Villarroya, Cristina Medrano; Villen, Alejandro Soria; Viramontes, Veronica; Vita, Caterina; Vujcic, Dunja; Wahba, Mona; Wan, Susan; Wang, Chih-Hsien; Warling, Xavier; Waters, Gerald; Waugh, Jane; Weiland, Lea; Weiner, Stefan; Weinreich, Thomas; Werth, Stephan Christian; Wickens, Olivia; Wijeratne, Vidu; Wilder, Karen; Willcocks, Lisa; Williams, Allister; Winiarska, Agata; Wirtz, Nikolaus; Wolf, Lothar; Wolf, Gunter; Wong, Muh Geot; Wong, Yick Hei; Wong, Sze Ho Sunny; Workeneh, Biruh; Wu, Ming-Ju; Wu, Hon-Yen; Wyndham, Roger; Yang, Jihyun; Yang, Ju-Yeh; Yeap, Chii; Yim, Ka Fai; Yong, Kenneth; Yoo, Tae-Hyun; Yoon, Songuk; Yu, Tung-Min; Yue, Tak Tai Andrew; Zakari, Michel; Zakauskiene, Urte; Zaoui, Philippe; Zbrzezniak, Justyna; Zielinska, Dorota; Zizzi, Carlotta Federica
Source
The Lancet; December 2023, Vol. 402 Issue: 10417 p2077-2090, 14p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.