학술논문
Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19
Document Type
Article
Author
Scutelnic, Adrian; van de Munckhof, Anita; Krzywicka, Katarzyna; van Kammen, Mayte Sánchez; Lindgren, Erik; Cordonnier, Charlotte; Kleinig, Timothy J; Field, Thalia S; Poli, Sven; Lemmens, Robin; Middeldorp, Saskia; Aaron, Sanjith; Borhani-Haghighi, Afshin; Arauz, Antonio; Kremer Hovinga, Johanna A; Günther, Albrecht; Putaala, Jukka; Wasay, Mohammad; Conforto, Adriana Bastos; de Sousa, Diana Aguiar; Jood, Katarina; Tatlisumak, Turgut; Ferro, José M; Coutinho, Jonathan M; Arnold, Marcel; Heldner, Mirjam R; Antonenko, Kateryna; Mbroh, Joshua; Brodard, Justine; Hooshmandi, Etrat; Dizonno, Vanessa; Devroye, Annemie; Ciccone, Alfonso; Wittstock, Matthias; Zimmermann, Julian; Bode, Felix J.; Skjelland, Mona; Duan, Jiangang; Hiltunen, Sini; Zuurbier, Susanna M.; Petruzzellis, Marco; Sharma, Aarti R.; Ghoreishi, Abdoreza; Elkady, Ahmed; Negro, Alberto; Gutschalk, Alexander; Schoenenberger, Silvia; Nagel, Simon; Buture, Alina; Cervera, Alvaro; Paiva Nunes, Ana; Romina Montané Baños, Ana; Tiede, Andreas; Puthuppallil, Anemon; Tuladhar, Anil M.; Mengel, Annerose; Medina, Antonio; Hellström Vogel, Åslög; Tawa, Audrey; Aujayeb, Avinash; Ramasamy, Balakrishnan; Casolla, Barbara; Lim Alvin Chew, Beng; Ziaadini, Bentalhoda; Varkey Maramattom, Boby; Buck, Brian; Zanferrari, Carla; Garcia-Esperon, Carlos; Vayne, Caroline; Legault, Catherine; Jacobi, Christian; Pfrepper, Christian; Pelz, Johann; Wahl, Christoph; Kern, Rolf; Tracol, Clement; Soriano, Cristina; Guisado-Alonso, Daniel; Bougon, David; Bal, Deepti; Sergio Zimatore, Domenico; Michalski, Dominik; Blacquiere, Dylan; Johansson, Elias; Cuadrado-Godia, Elisa; Sadeghi-Hokmabadi, Elyar; Carrera, Emmanuel; De Maistre, Emmanuel; Saxhaug Kristoffersen, Espen; Bonneville, Fabrice; Geeraerts, Thomas; Vuillier, Fabrice; Giammello, Fabrizio; D’Onofrio, Florindo; Grillo, Francesco; Caparros, François; Susen, Sophie; Maier, Frank; Tsivgoulis, Georgios; Gulli, Giosue; Frisullo, Giovanni; Franchineau, Guillaume; Cangür, Hakan; Katzberg, Hans; Mozhdehipanah, Hossein; Sibon, Igor; Baharoglu, M. Irem; Masjuan, Jaime; Brar, Jaskiran; Payen, Jean-Francois; Burrow, Jim; Fernandes, João; Octavio López Esparza, Jorge; Oen, Joyce; Schouten, Judith; Ng, Karl; Chatterton, Sophie; Wronski, Miriam; Althaus, Katharina; Garambois, Katia; Derex, Laurent; Puy, Laurent; Poorsaadat, Leila; Valler, Lenise; Januzi de Almeida Rocha, Letícia; Humbertjean, Lisa; Lebrato Hernandez, Lucia; Murillo-Bonilla, Luis; Kellermair, Lukas; Morin Martin, Mar; Sofia Cotelli, Maria; Hernandez Perez, Maria; Zedde, Marialuisa; Carvalho Dias, Mariana; Dubois, Marie-Cecile; Carvalho, Marta; Ghiasian, Masoud; Umaiorubahan, Meenakshisundaram; Kumar Karunakaran, Ravi; Roozbeh, Mehrdad; Romoli, Michele; Miranda, Miguel; Saadatnia, Mohammad; Bandettini di Poggio, Monica; Scholz, Moritz J.; Kahnis, Robert; Almasi-Dooghaee, Mostafa; Hoseininejad Mir, Nahid; Ichaporia, Nasli R.; Kumar Paramasivan, Naveen; Erat Sreedharan, Sapna; Sylaja, PN; Raposo, Nicolas; Fadakar, Nima; Kruyt, Nyika; Detante, Olivier; Cuisenier, Pauline; Huet, Olivier; Sharma, Pankaj; Candelaresi, Paolo; Scoppettuolo, Pasquale; Reiner, Peggy; Nemati, Reza; Vieira, Ricardo; Goh, Rudy; Murphy, Seán; Timsit, Serge; Coutts, Shelagh; Sharma, Shyam S.; Bal, Simerpreet; Kaul, Subhash; Karapanayiotides, Theodoros; Cox, Thomas; Gattringer, Thomas; Mathew, Thomas; Bartsch, Thorsten; Shaygannejad, Vahid; Garcia-Talavera, Veronica; Palma, Vincenzo; Arslan, Yıldız; Mirzaasgari, Zahra; Yavari, Zeinab; Zamani, Zohreh; Bakchoul, Tamam; Levi, Marcel; van Gorp, Eric C.M.
Source
European Stroke Journal; December 2023, Vol. 8 Issue: 4 p1001-1010, 10p
Subject
Language
ISSN
23969873; 23969881
Abstract
Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men.Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men.Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ.Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.