학술논문
Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials
Document Type
Article
Author
Heier, Jeffrey S; Lad, Eleonora M; Holz, Frank G; Rosenfeld, Philip J; Guymer, Robyn H; Boyer, David; Grossi, Federico; Baumal, Caroline R; Korobelnik, Jean-Francois; Slakter, Jason S; Waheed, Nadia K; Metlapally, Ravi; Pearce, Ian; Steinle, Nathan; Francone, Anibal A; Hu, Allen; Lally, David R; Deschatelets, Pascal; Francois, Cedric; Bliss, Caleb; Staurenghi, Giovanni; Monés, Jordi; Singh, Rishi P; Ribeiro, Ramiro; Wykoff, Charles C; Cole, Abosede O; Gerstenblith, Adam T; Kotagiri, Ajay; Edwards, Albert O; Zambrano, Alberto D; Eaton, Alexander M; Rubowitz, Alexander; Lyon, Alice T; Chiang, Allen; Ho, Allen; Hu, Allen Y; Guerami, Amir H; Dessouki, Amr L; de Carvalho, André Corrêa Maia; Emanuelli, Andrés; Chang, Andrew A; Antoszyk, Andrew N; Francone, Anibal Andrés; Prasad, Anita; Wolf, Armin; Khanani, Arshad M; Abbey, Ashkan Michael; Moulana, Asma; Wihelm, Barbara; Sikorski, Bartosz L; Kuppermann, Baruch D; Wolff, Benjamin; Jewart, Brian H; Do, Brian K; Chan-Kai, Brian T; Mein, Calvin; Hoyng, Carel B; Awh, Carl C; Regillio, Carl; Zeolite, Carlos; Baumal, Caroline R; Creuzot-Garcher, Catherine; Maury, Catherine Français; Wykoff, Charles C; Newell, Charles K; Jhaveri, Chirag; Lohmann, Chris P; Dinah, Christiana B; Ma, Colin; Crawford, Courtney; Parke, D Wilkin; Lavinsky, Daniel; Roth, Daniel; Pieramici, Dante J; Moshfeghi, Darius M; Levin, Darrin; Saperstein, David A; Brown, David; Gaucher, David; Lally, David R; Liao, David S; Brown, David Warren; Goldstein, Debra; Marcus, Dennis; Chan, Derek G; Dhoot, Dilsher; Tacite, Domingo; Zalewski, Dominik; Espana, Edgar M; Lad, Eleonora M; Souied, Eric H; Suan, Eric P; Eting, Eva; Sola, Federico Furno; de Bats, Flore; Bandello, Francesco; Gómez-Ulla, Francisco; Devin, François; Holz, Frank G; Chen, Fred K; Makkouk, Fuad; Dyer, Gawain; Spital, George; Staurenghi, Giovanni; Stoller, Glenn; Cousins, Gwen; Salehi-Had, Hani; Agostini, Hansjürgen; Eleftheriadis, Haralabos; Weiss, Harold; Sultan, Harris C; Massé, Hélène; Pearce, Ian; Dias, Indra; Barbazetto, Irene; Rosenblatt, Irit; Suñer, Ivan J; Kovach, Jaclyn L; Kaluzny, Jakub; Borthwick, James; Howard, James G; Wong, James; Ernest, Jan; Němčanský, Jan; Ysasaga, Jason Edward; Handza, Jason M; Moreno, Javier Antonio Montero; Korobelnik, Jean-François; Heier, Jeffrey S; Arnold, Jennifer J; Brown, Jeremiah; Bafalluy, Joaquin; Pearlman, Joel; Pitcher, John D; Kitchens, John; Carlson, John P; Gilhotra, Jolly; Fein, Jordana; Monés, Jordi M; Luna, José Domingo; Moreno, José María Ruiz; Coney, Joseph M; Sallum, Juliana Maria Ferraz; Olsen, Karl R; Blobner, Katharina; Macoul, Katherine A; Oh, Kean T; Malik, Khurram Javed; Hattenbach, Lars-Olof; Kodjikian, Laurent; Neto, Laurentino Biccas; Singerman, Lawrence J; Altay, Lebriz; Sheck, Leo-H; Feiner, Leonard; Harris, Lindsey D; Chishold, Lionel D; Rao, Llewelyn J; Nehemy, Márcio Bittar; Elizalde, Maria Jose Capella; Gamulescu, Maria-Andreea; Saravia, Mario J; Johnson, Mark W; McKibbin, Martin; Maccumber, Mathew; Vidosevich, Matko; Ohr, Matthew P; Samuel, Michael A; Singer, Michael A; Cassell, Michael; Dollin, Michael; Elman, Michael J; Ip, Michael S; Goldstein, Michaella; Busquets, Miguel; Mititelu, Mihai; Shah, Milan; Veith, Miroslav; Fineman, Mitchell; Varano, Monica; Christmas, Nancy; Steinle, Nathan C; Chaudhry, Nauman; Chinskey, Nicholas D; Eter, Nicole; London, Nikolas J S; Mathalone, Nurit; Schlottmann, Patricio G; Coady, Patrick; Higgins, Patrick M; Raskauskas, Paul A; Yates, Paul A; Bernstein, Paul; Mitchell, Paul; Monsour, Paul; Raphaelian, Paul V; Stanga, Paulo E; Stodulka, Pavel; Issa, Peter Charbel; Pavan, Peter; Ferrone, Phil J; Oleksy, Piotr; Abraham, Prema; Mruthyunjaya, Prithvi; Nguyen, Quan Dong; Reddy, Rahul K; Khurana, Rahul N; Tuli, Raman; Tadayoni, Ramin; Katz, Randy Steven; Arora, Rashi; Schlingemann, Reinier O; Rosen, Richard B; Gale, Richard; Scartozzi, Richard; Isernharge, Ricky; Singh, Rishi P; Stoltz, Robert A; Avery, Robert L; Wirthlin, Robert S; Guymer, Robyn; Goldberg, Roger A; Frenkel, Ronald; Belfort, Rubens Jr; Mohand-Said, Saddek; Grisanti, Salvatore; Razavi, Sam; Fraser-Bell, Samantha; Shah, Sandeep N; Wickremasinghe, Sanjeewa; Haug, Sara Joy; Adrean, Sean D; Priglinger, Siegfried G; Esposti, Simona Degli; Guest, Stephen; Huddleston, Stephen; Itty, Sujit; Moon, Suk Jin; Bhatia, Sumit P; Gupta, Sunil; Patel, Sunil S; Garg, Sunir J; Joshi, Sunir; Nghiem-Buffet, Sylvia; Johnson, T Mark; Jaouni, Tareq; Ach, Thomas; Williams, Thomas R; Sheidow, Thomas; Cleland, Timothy P; You, Timothy T; Peto, Tunde; Konidaris, Vasileios; Gonzalez, Victor H; Korda, Vladimir; Freeman, William R; Bridges, William Z; Barak, Yoreh; Zagorski, Zbigniew; Yehoshua, Zohar; Dubska, Zora
Source
The Lancet; October 2023, Vol. 402 Issue: 10411 p1434-1448, 15p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Geographic atrophy is a leading cause of progressive, irreversible vision loss. The objectives of OAKS and DERBY were to assess the efficacy and safety of pegcetacoplan compared with sham treatment in patients with geographic atrophy.