학술논문
Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, placebo-controlled trial
Document Type
Article
Author
Dayan, Gustavo H; Rouphael, Nadine; Walsh, Stephen R; Chen, Aiying; Grunenberg, Nicole; Allen, Mary; Antony, Johannes; Asante, Kwaku Poku; Bhate, Amit Suresh; Beresnev, Tatiana; Bonaparte, Matthew I; Celle, Médéric; Ceregido, Maria Angeles; Corey, Lawrence; Dobrianskyi, Dmytro; Fu, Bo; Grillet, Marie-Helene; Keshtkar-Jahromi, Maryam; Juraska, Michal; Kee, Jia Jin; Kibuuka, Hannah; Koutsoukos, Marguerite; Masotti, Roger; Michael, Nelson L; Neuzil, Kathleen M; Reynales, Humberto; Robb, Merlin L; Villagómez Martínez, Sandra M; Sawe, Fredrick; Schuerman, Lode; Tong, Tina; Treanor, John; Wartel, T Anh; Diazgranados, Carlos A; Chicz, Roman M; Gurunathan, Sanjay; Savarino, Stephen; Sridhar, Saranya; Abalos, Karina; Accini, Jose; Aloysia, Naveena; Amuasi, John Humphrey; Ansah, Nana Akosua; Benkeser, David; Berge, Aude; Beyko, Hanna; Bilotkach, Oleksandra; Breuer, Thomas; Bonfanti, Alberto Cadena; Bukusi, Elisabeth; Canter, Richard; Carrillo, Jaime Augusto; Chansinghakul, Danaya; Coux, Florence; Das, Chandan; Das, Santa Kumar; Devlin, Louis; Espinoza, Luis; Fay, Michael; Follmann, Dean; Frago, Carina; Garinga, Agnes; Gilbert, Peter B; Gonzalez, Claudia; Granados, Maria Angelica; Guillery, Lea; Huang, Ying; Hudzina, Kathy; Jain, Manish; Kanodia, Piush; Khandelwal, Nitin; Mutuluuza, Cissy Kityo; Kiweewa, Francis; Kiwanuka, Noah; Kosolsak, Chalit; Kukian, Darshna; Kushwaha, Jitendra Singh; Laot, Thelma; Lopez-Medina, Eduardo; Macareno Arroyo, Hugo; Mandaliya, Kishorchandra; Mamod, Stephanie; Mangarule, Somnath; Martínez, Javier; McClelland, Scott; Menard, Lisa; Mendoza, Sandra; Mohapatra, Satyajit; Moreau, Catherine; Mugo, Nelly; Nduba, Videlis; Noriega, Fernando; Ntege, Patricia Nahirya; Okech, Brenda; Otero, Maria; Ouma, Samuel Gurrion; Oyieko, Janet; Paredes, Mercedes; Pardo, Erwin; Postol, Svitlana; Pekala, David; Peng, Penny; Py, Marie-Laure; Rivas, Enrique; Rivero, Rafael; Rodriguez, Edith; Saleh, Mansoor; Sánchez, Pedro; Sater, Nessryne; Shah, Jinen; Shrestha, Rajeev; Siika, Abraham; Singh, Chandramani; Singh, Veer Bahadur; Tamrakar, Dipesh; Tavares Da-Silva, Fernanda; Otieno Tina, Lucas; Velasquez, Hector; Wabwire, Deo; Wajja, Anne; Zaworski, Elodie; Zhang, Nianxian
Source
The Lancet Respiratory Medicine; 20230101, Issue: Preprints
Subject
Language
ISSN
22132600; 22132619
Abstract
COVID-19 vaccines with alternative strain compositions are needed to provide broad protection against newly emergent SARS-CoV-2 variants of concern. This study aimed to describe the clinical efficacy and safety of a bivalent SARS-CoV-2 recombinant protein vaccine as a two-injection primary series during a period of circulation of the omicron (B.1.1.529) variant.