학술논문
Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial
Document Type
Article
Author
Khanani, Arshad M; Patel, Sunil S; Staurenghi, Giovanni; Tadayoni, Ramin; Danzig, Carl J; Eichenbaum, David A; Hsu, Jason; Wykoff, Charles C; Heier, Jeffrey S; Lally, David R; Monés, Jordi; Nielsen, Jared S; Sheth, Veeral S; Kaiser, Peter K; Clark, Julie; Zhu, Liansheng; Patel, Hersh; Tang, Justin; Desai, Dhaval; Jaffe, Glenn J; Alezzandrini, Arturo; Francone, Anibal Andres; Bafalluy, Joaquín; Bainttein, Silvina; Luna Pinto, Jose; Saravia, Mario; Vidosevich, Matko; Zeolite, Carlos; Furno Sola, Federico; Chang, Andrew; Cornish, Elisa Eleanor Guida; Nguyen, Thanh; Findl, Oliver; Haas, Anton; Kralinger, Martina; Sacu, Stefan; Postelmans, Laurence Dominique; Farah, Michel; Maia, Mauricio; Nehemy, Marcio; Ali, Fareed; Brent, Michael; Dollin, Michael; Gonder, John; Kherani, Amin; Merkur, Andrew; Tuli, Raman; Lopera, Monica Marie; Rodriguez, Francisco; Bradvica, Mario; Ernest, Jan; Kalijurand, Kuldar; Noor, Kai; Cohen, Yves; Creuzot-Garcher, Catherine; De Bats, Flore; Devin, François; Français-Maury, Catherine; Kodjikian, Laurent; Korobelnik, Jean François; Le Mer, Yannick; Quaranta El Maftouhi, Maddalena; Razavi, Sam; Souied, Eric; Tadayoni, Ramin; Weber, Michel; Eter, Nicole; Feltgen, Nicolas; Grisanti, Salvatore; Walter, Peter; Liegl, Raffael; Lorenz, Katrin; Spital, Georg; Priglinger, Siegfried; Spitzer, Martin; Volker, Michael; Krohne, Tim; Jochmann, Claudia; Lohmann, Chris Patrick; Framme, Carsten; Kerenyi, Agnes; Papp, Andras; Seres, Andras; Toth-Molnar, Edit; Tsorbatzoglou, Alexis; Vajas, Atilla; Varsanyi, Balázs; Vogt, Gabor; Bar, Asaf; Eting, Eva; Hauser, David; Levy, Jamie; Mathalone, Nurit; Morori-Katz, Haia; Rosenblatt, Irit; Soudry-Zayit, Shiri; Trivizky, Omert; Bandello, Francesco; Ciardella, Antonio Pasquale; Figus, Michele; Giansanti, Fabrizio; Lanzetta, Paolo; Mariotti, Cesare; Mastropasqua, Leonardo; Midena, Edoardo; Parmeggiani, Francesco; Ricci, Federico; Simonelli, Francesca; Staurenghi, Giovanni; Viola, Francesco; Varano, Monica; Laganovska, Guna; Cisiecki, Sławomir; Jedrzejewski, Wojciech; Kaluzny, Jakub; Misiuk-Hojło, Marta; Abengoechea, Santiago; Iribarren, Javier Araiz; Ascaso, Franciso Javier; Cubero, Juan Manuel; Gallego-Pinazo, Roberto; Gomez-Ulla De Irazazabal, Francisco; Mestre, Ignasi Jürgens; Mones I Carilla, Jordi Manel; Montero Moreno, Javier; María Ruiz Moreno, José; Sararols Ramsay, Laura; Garcia Layana, Alfredo; Downey, Louise; Abraham, Prema; Alfaro, Daniel Virgil; Bagheri, Nika; Barbazetto, Irene; Benevento, Joseph; Bernstein, Paul; Bertolucci, George; Bhavsar, Abdhish; Bridges, William; Brooks, Harold Logan; Jr; Brown, Jamin; Brucker, Alexander; Calvo, Charles M.; Capone, Antonio; Carlson, John; Chan, Clement; Chang, Emmanuel; Chan-Kai, Brian; Chaudhry, Nauman; Chen, Sanford; Csaky, Karl; Cummings, Howard; Danzig, Carl; Dessouki, Amr; Dyer, David; Eaton, Alexander; Eichenbaum, David; Faber, David; Feldman, Robert; Finnen, Neil; Freeman, William; Frenkel, Ronald; Gonzales, Christine; Gonzalez, Victor; Gross, John; Gupta, Sunil; Hall, Edward; Han, Min-Kyu; Heier, Jeffrey; Hershberger, Vrinda; Higgins, Patrick; Hsu, Jason; Ip, Michael; Jablon, Eric; Jewart, Brian; John, Vishak; Jonisch, Jonathan; Joondeph, Brian; Kay, Christine; Khanani, Arshad; Kokame, Gregg T.; Kwun, Robert; Lai, Michael; Lally, David; Laud, Ketan; Lavina, Adrian; Lee, Michael; Lin, Phoebe; Lin, Haijiang; Manoharan, Niranjan; Marcus, Dennis; Martidis, Adam; McCabe, Frank; Nielsen, Jared; Osher, James; Palmer, James; Patel, Sunil; Pearlman, Joel; Perkins, Stephen; Pirouz, Ashkan; Qureshi, Jawad; Randolph, John; Piri, Niloofar; Rosenfeld, Phillip; Saperstein, David; Scartozzi, Richard; Schwartz, Steven; Sharma, Ashish; Sharma, Atul; Sheth, Veeral; Singer, Michael; Spinak, David; Suan, Eric; Tabandeh, Homayoun; Tabassian, Ali; Uchiyama, Eduardo; Varenhorst, Michael; Wagner, Alan; Warrow, David; Wells, John; Wong, Robert; Wong, Keye; Wykoff, Charles; Xavier, Samantha; Ysasaga, Edward
Source
The Lancet; 20230101, Issue: Preprints
Subject
Language
ISSN
01406736; 1474547X
Abstract
Geographic atrophy is an advanced form of dry age-related macular degeneration that can lead to irreversible vision loss and high burden of disease. We aimed to assess efficacy and safety of avacincaptad pegol 2 mg in reducing geographic atrophy lesion growth.