학술논문
Immunological effects and safety of live rotavirus vaccination after antenatal exposure to immunomodulatory biologic agents: a prospective cohort study from the Canadian Immunization Research Network
Document Type
Article
Author
Fitzpatrick, Tiffany; Alsager, Khaled; Sadarangani, Manish; Pham-Huy, Anne; Murguía-Favela, Luis; Morris, Shaun K; Seow, Cynthia H; Piché-Renaud, Pierre-Philippe; Jadavji, Tajdin; Vanderkooi, Otto G; Top, Karina A; Constantinescu, Cora; Cowan, Juthaporn; Comeau, Jeannette; Derfalvi, Beata; Halperin, Scott A; Burton, Catherine; Suresh, Sneha; Vaudry, Wendy; Finlay, Jane; Dharmani, Poonam
Source
The Lancet Child & Adolescent Health; September 2023, Vol. 7 Issue: 9 p648-656, 9p
Subject
Language
ISSN
23524642; 23524650
Abstract
People with inflammatory or autoimmune diseases are recommended to continue immunomodulatory biologic agents throughout pregnancy. However, concerns regarding potential immunosuppression in infants exposed to biologic agents have led to recommendations to avoid live vaccines in the first 6–12 months of life. We aimed to examine whether live rotavirus vaccine could be administered safely to infants exposed to biologic agents, assessed in the Canadian Special Immunization Clinic (SIC) Network.