학술논문
Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial
Document Type
Article
Author
Stambler, Bruce S; Camm, A John; Alings, Marco; Dorian, Paul; Heidbuchel, Hein; Houtgraaf, Jaco; Kowey, Peter R; Merino, Jose L; Mondésert, Blandine; Piccini, Jonathan P; Pokorney, Sean D; Sager, Philip T; Verma, Atul; Wharton, J Marcus; Bharucha, David B; Plat, Francis; Shardonofsky, Silvia; Chen, Michael; Ip, James E; Ip, James E; Jones, Alonzo; Stambler, Bruce S; Schleinkofer, David E; Winters, Stephen; Lam, Wilson; Goldstein, Robert; Dor, Isaac Dor; Talwar, Sandeep; O'Neill, Padraig G; Koren, Michael J; Beinart, Sean C; Ambati, Srivani; Mazer, Sean P; Kinn, Robert M; Roy, Karine; Manshadi, Ramin; Kuk, Richard; Verma, Aditya; Phelan, Timothy; Stoian, Alexandru A; Ellenbogen, Kenneth; Jayachandran, J Vijay; Connelly, Terence P; Daccarett, Marcos; Gandhi, Gaurang; Mittal, Suneet; Abdel-Wahab, Amir; Augostini, Ralph; Ip, John H; Sorrentino, Denise; Roux, Jean-Francois; Brar, Ramandeep; Khoo, Clarence; Bennett, Matthew; Lo, Eric; Coutu, Benoit; Sterns, Laurence; Greer, Gerald S; Gujja, Pradeep; Gianfagna, Robert A; Swarup, Vijendra; Sogade, Felix; Wilton, Stephen; Ruisi, Christopher; Barbera, Saverio; Banchs, Javier E.; Korley, Victoria; Schulze, Christopher; Damle, Roger; Healey, Jeffrey Sean; Pandey, A Shekhar; Anderson, Jeffrey L; Venkatachalam, K L; Noseworthy, Peter; Mondésert, Blandine; Verma, Atul; Friars, Douglas G; Kambur, Thomas R; Lockwood, Evan; Meininger, Glenn; Olsovsky, Greg; Jones Sr, Alonzo; Greer, Gerald; Mehta, Rohit; Akbar, Saleem; Salman, Malik; Rama, Bhola; Arora, Ramesh; Shah, Dhirenkumar; Shah, Rakesh; Cammarata, Michael; Owens, Andrew; Ludington, Katherine; Wharton, Marcus; Bagheri, Michael; Khan, Mohammed; Carr, Kenneth Warren; Siddique, Sultan; Parvathaneni, Sunthosh; Devabhaktuni, Subodh; Mouhaffel, Assad; Mark, George; Di Biase, Luigi; Rangappa, Sunil; Morton, Jared; Yarmohammadi, Hirad; Karim, Amin; Martinez Fleites, Aldo; Nero, Thomas; Shafiq, Qaiser; Coutu, Benoit; Pandey, Shekhar; Khaykin, Yaariv; Joza, Jacqueline; Gosselin, Gilbert; Skanes, Allen; Vyselaar, John; Savard, Daniel; Heidbuchel, Hein; Xhaet, Olivier; Catez, Emmanuel; Vijgen, Johan; Godart, Pascal; Casado, Ruben; Mairesse, Georges; Rossenbacker, Tom; Haemers, Peter; Hoffer, Etienne; Hausman, Pierre; Vertes, Andras; Duray, Gabor; Szolnoki, Erzsebet; Csanadi, Zoltan; Lakatos, Ferenc; Alings, Marco; Dorman, Reinhart; Tuininga, Y S; Jansen, W; Velthuis, Sebastiaan; van Bemmel, B; Bech, Gerhard Jan Willem; Pisters, Ron; Valk, Suzanne; Romer, Tjeerd; Luermans, Justin; Beelen, Driek; van Eck, Martijn; Houtgraaf, Jaco; Vet, Thijs; Shellings, Dirk; Oosterhof, T; Miekus, Pawel; Bebenek, Waldemar; Bielecka-Dabrowa, Agata; Gniot, Jacek; Zmuda, Witold; Kasprzak, Michal; Balak, Wojciech; Ptaszynski, Pawel; Nowak, Jacek; Prokopczuk, Janusz; Przybylski, Andrzej; Wozniak-Skowerska, Iwona; Derejko, Pawel; Czarnecka, Danuta; Janas, Adam; Merino Llorens, Jose Luis; Tercedor, Luis; Iniguez Romo, Andres; Ruiz Granell, Ricardo; Gonzalez Juanatey, Jose Ramon; Pascual-Figal, Domingo; Martinez-Selles, Manuel; Anguera Camos, Ignacio; Ibanez Criado, Alicia; Matrinez Basterra, Javier; Izquierdo, Alvaro; Rivas Gandara, Nuria; Alegret Colome, Josep M; Perez Diez, Diego; Martínez Hervás, Miguel Ángel; Medina, Maria; Segura Saint-Gerons, Jose María; Pedrote Leal, Alonso; Fernandez Lozano, Ignacio; Quesada, Aurelio; Guerra Ramos, Jose; Sarrias, Axel; Ramos Maqueda, Javier; Mansourati, Jacques; Defaye, Pascal; Guedon-Moreau, Laurence; Milhem, Antoine; De Guillebon, Maxime; Chevalier, Philippe; Badoz, Marc; Kriatselis, Charalampos; Simonis, Gregor; Lewalter, Thorsten; Zarse, Markus; Wilke, Andreas; Kraemer, Fabian; Al-Zoebi, Ayham
Source
The Lancet; July 2023, Vol. 402 Issue: 10396 p118-128, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Etripamil is a fast-acting, intranasally administered calcium-channel blocker in development for on-demand therapy outside a health-care setting for paroxysmal supraventricular tachycardia. We aimed to evaluate the efficacy and safety of etripamil 70 mg nasal spray using a symptom-prompted, repeat-dose regimen for acute conversion of atrioventricular-nodal-dependent paroxysmal supraventricular tachycardia to sinus rhythm within 30 min.