학술논문
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial
Document Type
Article
Author
Brown, Samuel M; Barkauskas, Christina E; Grund, Birgit; Sharma, Shweta; Phillips, Andrew N; Leither, Lindsay; Peltan, Ithan D; Lanspa, Michael; Gilstrap, Daniel L; Mourad, Ahmad; Lane, Kathleen; Beitler, Jeremy R; Serra, Alexis L; Garcia, Ivan; Almasri, Eyad; Fayed, Mohamed; Hubel, Kinsley; Harris, Estelle S; Middleton, Elizabeth A; Barrios, Macy A G; Mathews, Kusum S; Goel, Neha N; Acquah, Samuel; Mosier, Jarrod; Hypes, Cameron; Salvagio Campbell, Elizabeth; Khan, Akram; Hough, Catherine L; Wilson, Jennifer G; Levitt, Joseph E; Duggal, Abhijit; Dugar, Siddharth; Goodwin, Andrew J; Terry, Charles; Chen, Peter; Torbati, Sam; Iyer, Nithya; Sandkovsky, Uriel S; Johnson, Nicholas J; Robinson, Bryce R H; Matthay, Michael A; Aggarwal, Neil R; Douglas, Ivor S; Casey, Jonathan D; Hache-Marliere, Manuel; Georges Youssef, J; Nkemdirim, William; Leshnower, Brad; Awan, Omar; Pannu, Sonal; O'Mahony, Darragh Shane; Manian, Prasad; Awori Hayanga, J W; Wortmann, Glenn W; Tomazini, Bruno M; Miller, Robert F; Jensen, Jens-Ulrik; Murray, Daniel D; Bickell, Nina A; Zatakia, Jigna; Burris, Sarah; Higgs, Elizabeth S; Natarajan, Ven; Dewar, Robin L; Schechner, Adam; Kang, Nayon; Arenas-Pinto, Alejandro; Hudson, Fleur; Ginde, Adit A; Self, Wesley H; Rogers, Angela J; Oldmixon, Cathryn F; Morin, Haley; Sanchez, Adriana; Weintrob, Amy C; Cavalcanti, Alexandre Biasi; Davis-Karim, Anne; Engen, Nicole; Denning, Eileen; Taylor Thompson, B; Gelijns, Annetine C; Kan, Virginia; Davey, Victoria J; Lundgren, Jens D; Babiker, Abdel G; Neaton, James D; Lane, H Clifford; Tierney, John; Vogel, Susan E.; McNay, Laura A.; Cahill, Kelly; Crew, Page; Sardana, Ratna; Segal Raim, Sharo; Shaw-Saliba, Katy; Atri, Negin; Miller, Mark; Vallee, David; Chung, Lucy; Delph, Yvette; Adam, Stacey J.; Read, Sarah; Draghia-Akli, Ruxandra; Harrigan, Rachel; Carlsen, Amy; Carter, Anita; DuChene, Alain; Eckroth, Kate; Frase, Alex; Harrison, Merrie; Meger, Sue; Quan, Kien; Quan, Siu Fun; Reilly, Cavan; Thompson, Greg; Walski, Jamie; Moskowitz, Alan J.; Bagiella, Emilia; Moquete, Ellen; O'Sullivan, Karen; Marks, Mary E.; Accardi, Evan; Kinzel, Emily; Bedoya, Gabriela; Gupta, Lopa; Overbey, Jessica R.; Padillia, Maria L.; Santos, Milerva; Gillinov, Marc A.; Miller, Marissa A.; Taddei-Peters, Wendy C.; Fenton, Kathleen; Smith, Peter K.; Vekstein, Andrew M.; Ko, Emily R.; Al-Hegelan, Mashael S.; McGowan, Lauren M.; Motta, Mary; Howell, Shauna; Bent, Francine; Kalager, Rachel; Chan, Emmanuel; Aloor, Heather L.; Griffin, S. Michelle; Covington, Anna; McLendon-Arvik, Beth; Bussadori, Barbara; Miller-Bell, Mary; Sampey, Cathy; Gaver, Vincent; Hollister, Beth A.; Giangiacomo, Dana M.; Pauley, Alena; Patel, Aashay; Classon, Chris; Frazier, Madison; Osborne, Robyn; Conlon, Debbi H.; Joshi, Marybeth; Gottlieb, Robert L.; Mack, Michael; Berhe, Mezgebe; Haley, Clinton; Dishner, Emma; Bettacchi, Christopher; Golden, Kevin; Duhaime, Erin; Ryan, Madison; Tallmadge, Catherine; Estrada, Lorie; Jones, Felecia; Villa, Samantha; Wang, Samantha; Robert, Raven; Coleman, Tanquinisha; Clariday, Laura; Baker, Rebecca; Hurutado-Rodriguez, Mariana; Iram, Nazia; Fresnedo, Michelle; Davis, Allyson; Leonard, Kiara; Ramierez, Noelia; Thammavong, Jon; Duque, Krizia; Turner, Emma; Fisher, Tammy; Robinson, Dianna; Ransom, Desirae; Maldonado, Nicholas; Lusk, Erica; Killian, Aaron; Palacios, Adriana; Solis, Edilia; Jerrow, Janet; Watts, Matthew; Whitacre, Heather; Cothran, Elizabeth; Bender, William; Miller, Jeffrey; Nugent, Katherine; Farrington, Woodrow; Baio, Kim T.; McBride, Mary K.; Fielding, Michele; Mathewson, Sonya; Porte, Kristina; Haley, Elizabeth; Rogers, Susan; Tyler, Derrick; Perin, Emerson; Costello, Briana; Postalian, Alexander; Sohail, Rizwan; Hinsu, Punit; Watson, Carolyn; Kappenman, Casey; Chen, James; Walker, Kim; Fink, Melyssa; Phillip, Gabrielle; Mahon, Kim; Sturgis, Lydia; Maher, Patrick; Rogers, Linda; Ng, Nicole; Marshall, Jason; Bassily-Marcus, Adel; Cohen, Ivy; Ramoo, Shamini; Malhotra, Aryan; Kessler, Jonathan; Goetz, Rebekah; Badhwar, Vinay; Hayanga, Jeremiah; Giblin Sutton, Lisa; Williams, Roger; Berry Bartolo, Elizabeth; Walker, Dmitry; Bunner, Robin; Glaze, Chad; Aucremanne, Tanja; Bishop, James; Kelley, Macey; Peterson, Autumn; Sauerborn, Erica; Reckart, Robin; Miller, Brittany; Mittel, Aaron; Darmanian, Anita; Rosen, Amanda; Madahar, Purnema; Schicchi, John; Gosek, Katarzyna; Dzierba, Amy; Wahab, Romina; Eng, Connie; Al-Saadi, Mukhtar; Zahiruddin, Faisal; Syed, Mohi; George, Michael; Patel, Varsha; Onwunyi, Chisom; Barroso da Costa, Rosa; North, Crystal; Ringwood, Nancy; Fitzgerald, Laura; Muzikansky, Ariela; Morse, Richard; Brower, Roy G.; Reineck, Lora A.; Bienstock, Karen; Hou, Peter; Steingrub, Jay S.; Tidswell, Mark A.; Kozikowski, Lori-Ann; Kardos, Cynthia; De Souza, Leslie; Talmor, Daniel; Shapiro, Nathan; Hibbert, Kathryn; Brait, Kelsey; Kone, Mamary; Hendey, Gregory; Kangelaris, Kirsten N.; Ashktorab, Kimia; Gropper, Rachel; Agrawal, Anika; Timothy, Kelly; Zhou, Hanjing; Hughes, Alyssa; Garcia, Rebekah; Torres, Adrian; Hernandez-Almaraz, Maria Elena; Vojnik, Rosemary; Perez, Cynthia; McDowell, Jordan; Chang, Steven Y.; Vargas, Julia; Moss, Marc; McKeehan, Jeffrey; Higgins, Carrie; Johnson, Emily; Slaughter, Suzanne; Wyles, David; Hiller, Terra; Oakes, Judy; Garcia, Ana; Gravitz, Stephanie; Lyle, Carolynn; Swanson, Diandra; Gong, Michelle Ng.; Richardson, Lynnne D.; Chen, Jen-Ting; Moskowitz, Ari; Mohamed, Amira; Lopez, Brenda; Amosu, Omowunmi; Tzehaie, Hiwet; Boujid, Sabah; Bixby, Billie; Lopez, Anitza A.; Durley, JaVon; Gilson, Boris; Hite, R. Duncan; Wang, Henry; Wiedemann, Hebert P.; Mehkri, Omar; Ashok, Kiran; King, Alexander; Brennan, Connery; Exline, Matthew C.; Englert, Joshua A.; Karow, Sarah; Schwartz, Elizabeth; So, Preston; So, Madison; Krol, Olivia F.; Briceno Parra, Genesis I.; Mills, Emmanuel Nii Lantei; Oh, Minn; Pena, Jose; Martínez, Jesús Alejandro; Jackman, Susan E.; Bayoumi, Emad; Pascual, Ethan; Caudill, Antonina; Chen, Po-En; Richardson, Tabia; Clapham, Gregg J.; Herrera, Lisa; Ojukwu, Cristabelle; Fine, Devin; Gomez, Millie J.; Choi-Kuaea, Yunhee; Weissberg, Gwendolyn; Isip, Katherine; Mattison, Brittany; Tran, Dana; Emilov Dukov, Jennifer; Chung, Paul; Kang, Bo Ran; Escobar, Lauren; Tran, Trung; Baig, Saba; Wallick, Julie A.; Duven, Alexandria M.; Fletcher, Dakota D.; Gundel, Stephanie; Fuentes, Megan; Newton, Maranda; Peterson, Emily; Jiang, Kelsey; Files, D. Clark; Miller, Chadwick; Lematty, Caitlin; Rasberry, April; Warden, Ashley; Bledsoe, Joseph; Knowlton, Kirk; Knox, Daniel B.; Klippel, Carolyn; Armbruster, Brent P.; Applegate, Darrin; Imel, Karah; Fergus, Melissa; Rahmati, Kasra; Jensen, Hannah; Aston, Valerie T.; Jeppson, Joshua; Marshall, J. Hunter; Lumpkin, Jenna; Smith, Cassie; Burke, Tyler; Gray, Andrew; Paine, Robert; Callahan, Sean; Yamane, Misty; Waddoups, Lindsey; Rice, Todd W.; Johnson, Jakea; Gray, Christopher; Hays, Margaret; Roth, Megan; Musick, Sarah; Miller, Karen; Semler, Matthew W.; Popielski, Laura; Kambo, Amy; Viens, Kimberly; Turner, Melissa; Vjecha, Michael J.; Denyer, Rachel; Khosla, Rahul; Rajendran, Bindu; Gonzales, Melissa; Moriarty, Theresa; Biswas, Kousick; Harrington, Cristin; Garcia, Amanda; Bremer, Tammy; Burke, Tara; Koker, Brittany; Pittman, David; Vasudeva, Shikha S.; Anholm, James D.; Specht, Lennard; Rodriguez, Aimee; Ngo, Han; Duong, Lien; Previte, Matthew; Raben, Dorthe; Nielsen, Charlotte B.; Friis Larsen, Jakob; Peters, Lars; Matthews, Gail; Kelleher, Anthony; Polizzotto, Mark; Carey, Catherine; Chang, Christina; Dharan, Nila; Hough, Sally; Virachit, Sophie; Davidson, Sarah; Bice, Daniel J.; Ognenovska, Katherine; Cabrera, Gesalit; Flynn, Ruth; Abdelghany, Mazin; Baseler, Beth; Teitelbaum, Marc; Holley, H. Preston; Jankelevich, Shirley; Adams, Amy; Becker, Nancy; Doleny, Suzanne; Hissey, Debbie; Simpson, Shelly; Kim, Mi Ha; Beeler, Joy; Harmon, Liam; Vanderpuye, Sharon; Yeon, Lindsey; Frye, Leanna; Rudzinski, Erin; Buehn, Molly; Eccard-Koons, Vanessa; Frary, Sadie; MacDonalad, Leah; Cash, Jennifer; Hoopengardner, Lisa; Linton, Jessica; Nelson, Michaela; Spinelli-Nadzam, Mary; Proffitt, Calvin; Lee, Christopher; Engel, Theresa; Fontaine, Laura; Osborne, CK; Hohn, Matt; Galcik, Michael; Thompson, DeeDee; Sandrus, Jen; Manchard, Jon; Giri, Jiwan; Kopka, Stacy; Chang, Weizhong; Sherman, Brad T.; Rupert, Adam W.; Highbarger, Helene; Baseler, Michael; Lallemand, Perrine; Rehman, Tauseef; Imamichi, Tom; Laverdure, Sylvain; Paudel, Sharada; Cook, Kyndal; Haupt, Kendra; Hazen, Allison; Badralmaa, Yunden; Highbarger, Jeroen; McCormack, Ashley; Gerry, Norman P.; Smith, Kenneth; Patel, Bhakti; Domeraski, Nadia; Hoover, Marie L.; DuChateau, Nadine; Flosi, Adam; Nelson, Rich; Stojanovic, Jelena; Wenner, Christine
Source
The Lancet Respiratory Medicine; 20240101, Issue: Preprints
Subject
Language
ISSN
22132600; 22132619
Abstract
There is a clinical need for therapeutics for COVID-19 patients with acute hypoxemic respiratory failure whose 60-day mortality remains at 30-50%. Aviptadil, a lung-protective neuropeptide, and remdesivir, a nucleotide prodrug of an adenosine analog, were compared with placebo among patients with COVID-19 acute hypoxaemic respiratory failure.