학술논문
Abstract P228: Accelerometer-Derived Daily Steps, Cognition, and Cognitive Impairment in U.S. Community-Dwelling Older Adults: The Atherosclerosis Risk in Communities Study
Document Type
Article
Author
Source
Circulation (Ovid); February 2023, Vol. 147 Issue: Supplement 1 pAP228-AP228, 1p
Subject
Language
ISSN
00097322; 15244539
Abstract
Introduction:Higher physical activity levels have been shown to preserve cognitive function and prevent cognitive impairment (CI). Whether daily steps, an easily interpretable physical activity metric, is associated with measures of brain health has not been widely studied.Hypothesis:Higher daily step count is associated with better cognitive function and lower odds of CI.Methods:Cross-sectional analysis of ARIC participants (mean age: 78 years, 41% male, 19% Black) who wore an accelerometer (ActiGraph GT3X) on the waist for ≥10 hours on ≥3 days between 2016-17. Daily steps were derived and examined continuously and by quartiles. Global and domain-specific (memory, language, executive function) factor scores were estimated from a battery of cognitive tests. Participants were classified as having CI if they had an adjudicated diagnosis of mild CI or dementia. Hypotheses were tested using linear and logistic regression models, adjusted for age, sex, race, education, and accelerometer wear time.Results:Among 454 participants, 88 (19.4%) had CI. The mean number of daily steps was 3,501 (SD=1,974). In adjusted models, a higher daily step count was associated with better global cognition and executive function factor scores (e.g., those in the 4thdaily-step quartile [≥4,499 steps] vs. 1st[<2074 steps] had a 0.43 [95% confidence interval: 0.24 to 0.61] higher executive function score). Associations of step count with memory or language scores were not supported. The odds of CI were lower for participants who had a higher daily steps count (e.g., those in the 4thdaily-step quartile vs. 1sthad 62% [odds ratio (OR)=0.38, 95% confidence interval: 0.16 to 0.90] lower odds of CI. The OR of CI for continuous daily steps shown in the Figure.Conclusions:Higher daily steps were associated with better cognitive function and may be a helpful marker in identifying participants with CI. Prospective studies of accelerometer-measured physical activity and cognitive outcomes are needed to understand the direction of these associations.