학술논문
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
Document Type
Article
Author
Mitchell, Kelly; Sprowls, Samuel A.; Arora, Sonali; Shakya, Sajina; Silver, Daniel J.; Goins, Christopher M.; Wallace, Lisa; Roversi, Gustavo; Schafer, Rachel E.; Kay, Kristen; Miller, Tyler E.; Lauko, Adam; Bassett, John; Kashyap, Anjali; D'Amato Kass, Jonathan; Mulkearns-Hubert, Erin E.; Johnson, Sadie; Alvarado, Joseph; Rich, Jeremy N.; Holland, Eric C.; Paddison, Patrick J.; Patel, Anoop P.; Stauffer, Shaun R.; Hubert, Christopher G.; Lathia, Justin D.
Source
Genes & Development; 2023, Vol. 37 Issue: 3-4 p86-102, 17p
Subject
Language
ISSN
08909369; 15495477
Abstract
Here, Mitchell et al. investigated the molecular mechanisms critical for CSC population maintenance. They developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulators in the SOX2-enriched, therapy-resistant niche and identified WDR5 as indispensable for this population. Their findings highlight the role of WDR5 and the WRAD complex in maintaining the CSC state and provide a rationale for therapeutic development of WDR5 inhibitors for GBM and other advanced cancers.