학술논문
Evaluation of expression of biomarkers of PLAGL1 (ZAC1),microRNA, and their non-coding RNAs in patients with endometriosis
Document Type
Article
Author
Source
Journal of Gynecology Obstetrics and Human Reproduction; April 2023, Vol. 52 Issue: 4
Subject
Language
ISSN
24688495; 24687847
Abstract
Since the PLAGL1(ZAC1) gene is expressed in the human endometrium. It may be involved in the etiology of endometrial disorders by its abnormal regulation and expression. This study aimed to investigate the Zac1 gene and related microRNA and LncRNA and its alterations in patients with endometriosis. Blood plasma, ectopic (EC) and eutopic (EU) endometrial samples were gathered from 30 patients with endometriosis and 30 healthy fertile women, and the Q-PCR technique was used to determine the expression level of Zac1mRNA and microRNAs (miR-1271–5p, hsa-miR-490–3pin) and LncRNAs (TONSL-AS1 TONSL, KCNQ1OT1 KCNQ1). According to the results, the Zac1gene and KCNQ1OT1 KCNQ1, TONSL-AS1 TONSLLncRNA expression were significantly decreased in the endometriosis group versus the control group (P <0.05). MiR-1271–5pand hsa-miR-490–3pinmicroRNA expression were significantly raised in the endometriosis group as opposed to the control group (P <0.05). In summary, this research for the first time revealed that identifying Zac1expression provides us with new indicators for evaluating endometriosis.