학술논문
A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study
Document Type
Article
Author
Swen, Jesse J; van der Wouden, Cathelijne H; Manson, Lisanne EN; Abdullah-Koolmees, Heshu; Blagec, Kathrin; Blagus, Tanja; Böhringer, Stefan; Cambon-Thomsen, Anne; Cecchin, Erika; Cheung, Ka-Chun; Deneer, Vera HM; Dupui, Mathilde; Ingelman-Sundberg, Magnus; Jonsson, Siv; Joefield-Roka, Candace; Just, Katja S; Karlsson, Mats O; Konta, Lidija; Koopmann, Rudolf; Kriek, Marjolein; Lehr, Thorsten; Mitropoulou, Christina; Rial-Sebbag, Emmanuelle; Rollinson, Victoria; Roncato, Rossana; Samwald, Matthias; Schaeffeler, Elke; Skokou, Maria; Schwab, Matthias; Steinberger, Daniela; Stingl, Julia C; Tremmel, Roman; Turner, Richard M; van Rhenen, Mandy H; Dávila Fajardo, Cristina L; Dolžan, Vita; Patrinos, George P; Pirmohamed, Munir; Sunder-Plassmann, Gere; Toffoli, Giuseppe; Guchelaar, Henk-Jan; Buunk, Annemarie; Goossens, Hanneke; Baas, Gert; Algera, Maartje; Schuil-Vlassak, Evelyn; Ambagts, Thijs; De Hoog-Schouten, Leonie; Musaafir, Sara; Bosch, Roelof; Tjong, Carol; Steeman, Sanne; Van der Plas, Martine; Baldew, Glenn; Den Hollander, Iris; De Waal, Zacharias; Heijn, Aurele; Nelemans, Leen; Kouwen-Lubbers, Kirsten; Van Leeuwen, Maartje; Hoogenboom, Sacha; Van Doremalen, Jacobine; Ton, Célin; Beetstra, Bastien; Meijs, Veronique; Dikken, Jan; Dubero, Dasha; Slager, Mark; Houben, Tom; Kanis, Thomas; Overmars, Wietske; Nijenhuis, Marga; Steffens, Michael; Bergs, Ingmar; Karamperis, Kariofyllis; Siamoglou, Stavroula; Ivantsik, Ouliana; Samiou, Georgia-Chryssa; Kordou, Zoe; Tsermpini, Evira; Ferentinos, Panagiotis; Karaivazoglou, Aikaterini; Rigas, George; Gerasimou, Harilaos; Voukelatou, Georgia; Georgila, Eleni; Tsermpini, Evangelia Eirini; Mendrinou, Efrossyni; Chalikiopoulou, Konstantina; Kolliopoulou, Alexandra; Mitropoulos, Konstantinos; Stratopoulos, Apostolos; Liopetas, Ioannis; Tsikrika, Athina; Barba, Evangelia; Emmanouil, Georgia; Stamopoulou, Theano; Stathoulias, Andreas; Giannopoulos, Panagiotis; Kanellakis, Filippos; Bartsakoulia, Marina; Katsila, Theodora; Douzenis, Athanassios; Gourzis, Filippos; Assimakopoulos, Konstantinos; Bignucolo, Alessia; Dal Cin, Lisa; Comello, Francesco; Mezzalira, Silvia; Puglisi, Fabio; Spina, Michele; Foltran, Luisa; Guardascione, Michela; Buonadonna, Angela; Bartoletti, Michele; Corsetti, Serena; Ongaro, Elena; Da Ros, Lucia; Bolzonello, Silvia; Spazzapan, Simon; Freschi, Andrea; Di Nardo, Paola; Palazzari, Elisa; Navarria, Federico; Innocente, Roberto; Berretta, Massimiliano; D'Andrea, Mario; Angelini, Francesco; Diraimo, Tania; Favaretto, Adolfo; Dávila-Fajardo, Cristina Lucía; Díaz-Villamarín, Xando; Martínez-González, Luis Javier; Antúnez-Rodríguez, Alba; Moreno-Escobar, Eduardo; Fernández-Gonzalez, Ana Estefanía; García-Navas, Paloma; Bautista-Pavés, Alicia Bautista Pavés; Burillo-Gómez, Francisco; Villegas-Rodríguez, Inmaculada; Sánchez-Ramos, Jesús Gabriel; Antolinos-Pérez, Mª José; Rivera, Ricardo; Martínez-Huertas, Susana; Thomas-, Jesús; Carazo, Jose Julio; Yañez-Sanchez, Mª Isabel; Blancas-López-Navajas, Rocío; García-Orta, Beatriz; González-Astorga, Carlos José; Rodríguez-González, Francisco Javier; Ruiz-Carazo, Manuel; López-Pérez, Irene; Cano-Herrera, Rosa; Herrera, Teresa; Gil-Jiménez; Delgado-Ureña, Mª Teresa; Triviño-Juarez, Jose Matías; Campos-Velázquez, Salustiano; Alcántara-Espadafor, Silvia; Moreno Aguilar, Maria Rosario; Ontiveros-Ortega, Maria Carmen; Carnerero-Córdoba, Lidia; Guerrero-Jiménez, Margarita; Legeren-Álvarez, Marta; Yélamos-Vargas, Marisol; Castillo-Pérez, Isabel; Aomar-Millán, Ismael; Anguita-Romero, Manuel; Sánchez-García, María José; Sequero-Lopez, Silvia; Faro-Miguez, Naya; López-Fernández, Silvia; Leyva-Ferrer, Rosario Nieves; Herrera-Gómez, Norberto; Pertejo-Manzano, Laura; Pérez-Gutierrez, Eva Mª; Martín-de la Higuera, Antonio J.; Plaza-Carrera, Jose; Baena-Garzón, Flor; Toledo-Frías, Pablo; Cruz-Valero, Inés; Chacón-McWeeny, Verónica; Gallardo-Sánchez, Isabel; Arrebola, Antonio; Guillén-Zafra, Lucía; Ceballos-Torres, Ángel; Guardia-Mancilla, Plácido; Guirao-Arrabal, Emilio; Canterero-Hinojosa, Jesús; Velasco-Fuentes, Sara; Sánchez-Cano, Daniel; Aguilar-Jaldo, Mª del Pilar; Caballero-Borrego, Juan; Praznik, Monika; Slapšak, Urška; Vončina, Blaz; Rajter, Branka; Škrinjar, Andrej; Marjetič Ulčakar, Angelika; Zidanšek, Anja; Stegne Ignjatvič, Tea; Mazej Poredoš, Barbara; Vivod Pečnik, Živka; Poplas Susič, Tonka; Juteršek, Milojka; Klen, Jasna; Skoporc, Janja; Kotar, Tjaša; Petek Šter, Marija; Zvezdana Dernovšk, Mojca; Klen, Jasna; Mlinšek, Gregor; Miklavčič, Petra; Plemenitaš Ilješ, Anja; Grašič Kuhar, Cvetka; Oblak, Irena; Stražišar, Branka; Štrbac, Danijela; Matos, Erika; Mencinger, Marina; Vrbnjak, Marko; Saje, Marko; Radovanovič, Mirjana; Jeras, Katja; Bukovec, Lucija; Terzič, Tea; Minichmayr, Iris; Nanah, Abdulaziz; Nielsen, Elisabet; Zou, Yuanxi; Lauschke, Volker; Johansson, Inger; Zhou, Yitian; Nordling, Åsa; Aigner, Christof; Dames-Ludwig, Marlies; Monteforte, Rossella; Sunder-Plassmann, Raute; Steinhauser, Corinna; Sengoelge, Guerkan; Winnicki, Wolfgang; Schmidt, Alice; Vasileios, Fragoulakis; Fontana, Vanessa; Hanson, Anita; Little, Margaret; Hornby, Rachael; Dello Russo, Cinzia; French, Stephanie; Hampson, Jamie; Gumustekin, Mukaddes; Anyfantis, George; Hampson, Lucy; Lewis, David; Westhead, Ruth; Prince, Clare; Rajasingam, Arjunan
Source
The Lancet; February 2023, Vol. 401 Issue: 10374 p347-356, 10p
Subject
Language
ISSN
01406736; 1474547X
Abstract
The benefit of pharmacogenetic testing before starting drug therapy has been well documented for several single gene–drug combinations. However, the clinical utility of a pre-emptive genotyping strategy using a pharmacogenetic panel has not been rigorously assessed.