학술논문
Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury
Document Type
Article
Author
Cai, Lanya T.; Brett, Benjamin L.; Palacios, Eva M.; Yuh, Esther L.; Bourla, Ioanna; Wren-Jarvis, Jamie; Wang, Yang; Mac Donald, Christine; Diaz-Arrastia, Ramon; Giacino, Joseph T.; Okonkwo, David O.; Levin, Harvey S.; Robertson, Claudia S.; Temkin, Nancy; Markowitz, Amy J.; Manley, Geoffrey T.; Stein, Murray B.; McCrea, Michael A.; Zafonte, Ross D.; Nelson, Lindsay D.; Mukherjee, Pratik; Ferguson, Adam R.; Manley, Geoffrey T.; Markowitz, Amy J.; Mukherjee, Pratik; Taylor, Sabrina R.; Yue, John K.; Yuh, Esther L.; Jha, Ruchira; Gopinath, Shankar; Robertson, Claudia S.; Giacino, Joseph T.; McCrea, Michael A.; Nelson, Lindsay D.; Diaz-Arrastia, Ramon; Jain, Sonia; Stein, Murray B.; Ngwenya, Laura B.; Badjatia, Neeraj; Gullapalli, Rao; Korley, Frederick K.; Okonkwo, David O.; Puccio, Ava M.; Schnyer, David; Madden, Christopher; Grandhi, Ramesh; Dirk Keene, C.; Mac Donald, Christine; Temkin, Nancy; Merchant, Randall
Source
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; February 2024, Vol. 9 Issue: 2 p164-175, 12p
Subject
Language
ISSN
24519022
Abstract
Adult patients with mild traumatic brain injury (mTBI) exhibit distinct phenotypes of emotional and cognitive functioning identified by latent profile analysis of clinical neuropsychological assessments. When discerned early after injury, these latent clinical profiles have been found to improve prediction of long-term outcomes from mTBI. The present study hypothesized that white matter (WM) microstructure is better preserved in an emotionally resilient mTBI phenotype compared with a neuropsychiatrically distressed mTBI phenotype.