학술논문
Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients
Document Type
Article
Author
Morath, Christian; Schaier, Matthias; Ibrahim, Eman; Wang, Lei; Kleist, Christian; Opelz, Gerhard; Süsal, Caner; Ponath, Gerald; Aly, Mostafa; Alvarez, Cristiam M.; Kälble, Florian; Speer, Claudius; Benning, Louise; Nusshag, Christian; Pego da Silva, Luiza; Sommerer, Claudia; Hückelhoven-Krauss, Angela; Czock, David; Mehrabi, Arianeb; Schwab, Constantin; Waldherr, Rüdiger; Schnitzler, Paul; Merle, Uta; Tran, Thuong Hien; Scherer, Sabine; Böhmig, Georg A.; Müller-Tidow, Carsten; Reiser, Jochen; Zeier, Martin; Schmitt, Michael; Terness, Peter; Schmitt, Anita; Daniel, Volker
Source
Journal of the American Society of Nephrology; January 2023, Vol. 34 Issue: 1 p160-174, 15p
Subject
Language
ISSN
10466673; 15333450
Abstract
In previous work, the authors demonstrated that kidney transplant recipients developed donor-specific unresponsiveness when they were given a pretransplant infusion of modified donor-derived PBMCs. In this study, they provide evidence that the immunosuppressive properties of these cells persist and the donor-specific unresponsiveness is long-lasting. In the four patients who received the highest dose of the modified immune cells, administration of these cells was associated with a striking increase in IL-10–producing regulatory B lymphocytes and evidence of the consensus gene expression signature of operational tolerance. In vitro, donor-specific unresponsiveness was abolished after B lymphocyte depletion, suggesting a direct pathophysiologic role for regulatory B lymphocytes. These findings support the notion that modified donor-derived PBMCs may be useful in kidney transplantation, but this approach requires further validation and rigorous controlled randomized studies.