학술논문
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial
Document Type
Article
Author
Hricik, Donald E.; Armstrong, Brian; Alhamad, Tarek; Brennan, Daniel C.; Bromberg, Jonathan S.; Bunnapradist, Suphamai; Chandran, Sindhu; Fairchild, Robert. L.; Foley, David P.; Formica, Richard; Gibson, Ian W.; Kesler, Karen; Kim, S. Joseph; Mannon, Roslyn B.; Menon, Madhav C.; Newell, Kenneth A.; Nickerson, Peter; Odim, Jonah; Poggio, Emilio D.; Sung, Randall; Shapiro, Ron; Tinckam, Kathryn; Vincenti, Flavio; Heeger, Peter S.
Source
Journal of the American Society of Nephrology; January 2023, Vol. 34 Issue: 1 p145-159, 15p
Subject
Language
ISSN
10466673; 15333450
Abstract
Peritransplant TNF blockade with infliximab should not be used in recipients of deceased-donor kidney transplants due to lack of efficacy and an increased incidence of BK virus infection, according to results of a randomized controlled clinical trial. Our results underscore the need for properly controlled and powered trials to avoid falsely accepting unproven therapeutics and reporting incorrect low adverse event rates derived from small, uncontrolled experiments.