학술논문
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
Document Type
Article
Author
Kotanidis, Christos P; Xie, Cheng; Alexander, Donna; Rodrigues, Jonathan C L; Burnham, Katie; Mentzer, Alexander; O’Connor, Daniel; Knight, Julian; Siddique, Muhammad; Lockstone, Helen; Thomas, Sheena; Kotronias, Rafail; Oikonomou, Evangelos K; Badi, Ileana; Lyasheva, Maria; Shirodaria, Cheerag; Lumley, Sheila F; Constantinides, Bede; Sanderson, Nicholas; Rodger, Gillian; Chau, Kevin K; Lodge, Archie; Tsakok, Maria; Gleeson, Fergus; Adlam, David; Rao, Praveen; Indrajeet, Das; Deshpande, Aparna; Bajaj, Amrita; Hudson, Benjamin J; Srivastava, Vivek; Farid, Shakil; Krasopoulos, George; Sayeed, Rana; Ho, Ling-Pei; Neubauer, Stefan; Newby, David E; Channon, Keith M; Deanfield, John; Antoniades, Charalambos; Ahern, David J; Ai, Zhichao; Ainsworth, Mark; Allan, Chris; Allcock, Alice; Angus, Brian; Ansari, M Azim; Arancibia-Cárcamo, Carolina; Aschenbrenner, Dominik; Attar, Moustafa; Baillie, J Kenneth; Barnes, Eleanor; Bashford-Rogers, Rachael; Bashyal, Archana; Beer, Sally; Berridge, Georgina; Beveridge, Amy; Bibi, Sagida; Bicanic, Tihana; Blackwell, Luke; Bowness, Paul; Brent, Andrew; Brown, Andrew; Broxholme, John; Buck, David; Burnham, Katie; Byrne, Helen; Camara, Susana; Ferreira, Ivan Candido; Charles, Philip; Chen, Wentao; Chen, Yi-Ling; Chong, Amanda; Clutterbuck, Elizabeth; Coles, Mark; Conlon, Christopher; Cornall, Richard; Cribbs, Adam; Curion, Fabiola; Davenport, Emma; Davidson, Neil; Davis, Simon; Dendrou, Calliope; Dequaire, Julie; Dib, Lea; Docker, James; Dold, Christina; Dong, Tao; Downes, Damien; Drakesmith, Hal; Dunachie, Susanna; Duncan, David; Eijsbouts, Chris; Esnouf, Robert; Espinosa, Alexis; Etherington, Rachel; Fairfax, Benjamin; Fairhead, Rory; Fang, Hai; Fassih, Shayan; Felle, Sally; Fernandez Mendoza, Maria; Ferreira, Ricardo; Fischer, Roman; Foord, Thomas; Forrow, Aden; Frater, John; Fries, Anastasia; Gallardo Sanchez, Veronica; Garner, Lucy; Geeves, Clementine; Georgiou, Dominique; Godfrey, Leila; Golubchik, Tanya; Gomez Vazquez, Maria; Green, Angie; Harper, Hong; Harrington, Heather; Heilig, Raphael; Hester, Svenja; Hill, Jennifer; Hinds, Charles; Hird, Clare; Ho, Ling-Pei; Hoekzema, Renee; Hollis, Benjamin; Hughes, Jim; Hutton, Paula; Jackson-Wood, Matthew; Jainarayanan, Ashwin; James-Bott, Anna; Jansen, Kathrin; Jeffery, Katie; Jones, Elizabeth; Jostins, Luke; Kerr, Georgina; Kim, David; Klenerman, Paul; Knight, Julian; Kumar, Vinod; Kumar Sharma, Piyush; Kurupati, Prathiba; Kwok, Andrew; Lee, Angela; Linder, Aline; Lockett, Teresa; Lonie, Lorne; Lopopolo, Maria; Lukoseviciute, Martyna; Luo, Jian; Marinou, Spyridoula; Marsden, Brian; Martinez, Jose; Matthews, Philippa; Mazurczyk, Michalina; McGowan, Simon; McKechnie, Stuart; Mead, Adam; Mentzer, Alexander; Mi, Yuxin; Monaco, Claudia; Montadon, Ruddy; Napolitani, Giorgio; Nassiri, Isar; Novak, Alex; O'Brien, Darragh; O'Connor, Daniel; O'Donnell, Denise; Ogg, Graham; Overend, Lauren; Park, Inhye; Pavord, Ian; Peng, Yanchun; Penkava, Frank; Pereira Pinho, Mariana; Perez, Elena; Pollard, Andrew; Powrie, Fiona; Psaila, Bethan; Quan, T Phuong; Repapi, Emmanouela; Revale, Santiago; Silva-Reyes, Laura; Richard, Jean-Baptiste; Rich-Griffin, Charlotte; Ritter, Thomas; Rollier, Christine; Rowland, Matthew; Ruehle, Fabian; Salio, Mariolina; Sansom, Stephen Nicholas; Sanches Peres, Raphael; Santos Delgado, Alberto; Sauka-Spengler, Tatjana; Schwessinger, Ron; Scozzafava, Giuseppe; Screaton, Gavin; Seigal, Anna; Semple, Malcolm; Sergeant, Martin; Simoglou Karali, Christina; Sims, David; Skelly, Donal; Slawinski, Hubert; Sobrinodiaz, Alberto; Sousos, Nikolaos; Stafford, Lizzie; Stockdale, Lisa; Strickland, Marie; Sumray, Otto; Sun, Bo; Taylor, Chelsea; Taylor, Stephen; Taylor, Adan; Thongjuea, Supat; Thraves, Hannah; Todd, John; Tomic, Adriana; Tong, Orion; Trebes, Amy; Trzupek, Dominik; Tucci, Felicia Anna; Turtle, Lance; Udalova, Irina; Uhlig, Holm; van Grinsven, Erinke; Vendrell, Iolanda; Verheul, Marije; Voda, Alexandru; Wang, Guanlin; Wang, Lihui; Wang, Dapeng; Watkinson, Peter; Watson, Robert; Weinberger, Michael; Whalley, Justin; Witty, Lorna; Wray, Katherine; Xue, Luzheng; Yuen Yeung, Hing; Yin, Zixi; Young, Rebecca; Youngs, Jonathan; Zhang, Ping; Zurke, Yasemin-Xiomara; Banning, Adrian; Antonopoulos, Alexios; Bajaj, Amrita; Kelion, Andrew; Deshpande, Aparna; Kardos, Attila; Hudson, Benjamin; Koo, Bon-Kwon; Shirodaria, Cheerag; Xie, Cheng; Kotanidis, Christos; Mahon, Ciara; Berry, Colin; Adlam, David; Newby, David; Connolly, Derek; Scaletta, Diane; Alexander, Donna; Nicol, Ed; McAlindon, Elisa; Oikonomou, Evangelos; Pugliese, Francesca; Pontone, Gianluca; Benedetti, Giulia; He, Guo-Wei; West, Henry; Kondo, Hidekazu; Benedek, Imre; Das, Intrajeet; Deanfield, John; Graby, John; Greenwood, John; Rodrigues, Jonathan; Ge, Junbo; Channon, Keith; Fabritz, Larissa; Fan, Li-Juan; Kingham, Lucy; Guglielmo, Marco; Lyasheva, Maria; Schmitt, Matthias; Beer, Meinrad; Anderson, Michelle; Desai, Milind; Marwan, Mohamed; Takahashi, Naohiko; Mehta, Nehal; Dai, Neng; Screaton, Nicholas; Sabharwal, Nikant; Maurovich-Horvat, Pál; Rao, Praveen; Kotronias, Rafail; Kharbanda, Rajesh; Preston, Rebecca; Wood, Richard; Blankstein, Ron; Rajani, Ronak; Mirsadraee, Saeed; Munir, Shahzad; Thomas, Sheena; Neubauer, Stefan; Klömpken, Steffen; Petersen, Steffen; Achenbach, Stephan; Anthony, Susan; Mak, Sze; Mittal, Tarun; Benedek, Theodora; Sharma, Vinoda; Lin, Wen-Hua
Source
The Lancet Digital Health; October 2022, Vol. 4 Issue: 10 pe705-e716, 12p
Subject
Language
ISSN
25897500
Abstract
Direct evaluation of vascular inflammation in patients with COVID-19 would facilitate more efficient trials of new treatments and identify patients at risk of long-term complications who might respond to treatment. We aimed to develop a novel artificial intelligence (AI)-assisted image analysis platform that quantifies cytokine-driven vascular inflammation from routine CT angiograms, and sought to validate its prognostic value in COVID-19.