학술논문
Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial
Document Type
Article
Author
Schlaich, Markus P; Bellet, Marc; Weber, Michael A; Danaietash, Parisa; Bakris, George L; Flack, John M; Dreier, Roland F; Sassi-Sayadi, Mouna; Haskell, Lloyd P; Narkiewicz, Krzysztof; Wang, Ji-Guang; Reid, Christopher; Schlaich, Markus; Katz, Ivor; Ajani, Andrew; Biswas, Sinjini; Esler, Murray; Elder, Grahame; Roger, Simon; Colquhoun, David; Mooney, John; De Backer, Tine; Persu, Alexandre; Chaumont, Martin; Krzesinski, Jean-Marie; Vanassche, Thomas; Girard, Ginette; Pliamm, Lew; Schiffrin, Ernesto; Merali, Fatima; Dresser, George; Vallee, Michel; Jolly, Shivinder; Chow, Stephen; Wang, Jiguang; Mu, Jianjun; Yu, Jing; Yuan, Hong; Feng, Yingqing; Zhang, Xin; Xie, Jianhong; Lin, Ling; Soucek, Miroslav; Widimsky, Jiri; Cifkova, Renata; Vaclavik, Jan; Ullrych, Martin; Lukac, Martin; Rychlik, Ivan; Guldager Lauridsen, Thomas; Kantola, Ilkka; Taurio, Jyrki; Ukkola, Olavi; Ormezzano, Olivier; Gosse, Philippe; Azizi, Michel; Courand, Pierre-Yves; Delsart, Pascal; Tartiere, Jean Michel; Mahfoud, Felix; Schmieder, Roland; Stegbauer, Johannes; Lurz, Philipp; Koziolek, Michael; Ott, Christian; Toursarkissian, Nicole; Tsioufis, Konstantinos; Kyfnidis, Konstantinos; Manolis, Athanasios; Patsilinakos, Sotirios; Zebekakis, Pantelis; Karavidas, Apostolos; Denes, Pall; Bezzegh, Katalin; Zsom, Marianna; Kovacs, Laszlo; Sharabi, Yehonatan; Elias, Mazen; Sukholutsky, Ivetta; Yosefy, Chaim; Kenis, Irina; Atar, Shaul; Volpe, Massimo; Maria Lorenza, Muiesan; Taddei, Stefano; Grassi, Guido; Veglio, Franco; Son, Jung Woo; Kim, Jang-Young; Park, Joong-Il; Lee, Chang Hoon; Lee, Hae-Young; Raugaliene, Rasa; Marcinkeviciene, Jolanta Elena; Kavaliauskiene, Roma; Deinum, Jaap; Kroon, Abraham; van den Born, Bert-Jan; Januszewicz, Andrzej; Tykarski, Andrzej; Walczewska, Jolanta; Gaciong, Zbigniew; Wiecek, Andrzej; Chrostowska, Marzena; Kleinrok, Andrzej; Krekora, Jan; Kania, Grzegorz; Podrazka-Szczepaniak, Anna; Golawski, Cezary; Podziewski, Maciej; Kaczmarek, Barbara; Skoczylas, Grzegorz; Wilkolaski, Andrzej; Wozniak, Iwona; Janik-Palazzolo, Marzena; Rewerska, Barbara; Konradi, Aleksandra; Shvarts, Yuriy; Pecherina, Tamara; Nikolaev, Konstantin; Liudmila, Gapon; Orlikova, Olga; Mordovin, Viktor; Petrochenkova, Natalia; Kamalov, Gadel; Kosmacheva, Elena; Nikolaev, Konstantin; Tyrenko, Vadim; Gorbunov, Vladimir; Obrezan, Andrey; Supryadkina, Tatiana; Ler, Irina; Kotenko, Oleg; Kuzin, Anatoly; Martínez García, Fernando; Redon, Josep; Oliveras, Anna; Beltran Romero, Luis; Shatylo, Valerii; Rudenko, Leonid; Bazylevych, Andriy; Rudyk, Yurii; Karpenko, Oleksandr; Stanislavchuk, Mykola; Tseluyko, Vira; Kushnir, Mykola; Asanov, Ervin; Sirenko, Yuriy; Yagensky, Andriy; Collier, David; Gupta, Pankaj; Webb, David; MacLeod, Mary; McLay, James; Peace, Aaron; Arora, Samir; Buchanan, Patricia; Harris, Robert; Degarmo, Ronald; Guillen, Mario; Karns, Adam; Neutel, Joel; Paliwal, Yogesh; Pettis, Karlton; Toth, Phillip D.; Wayne, Jeffrey M.; Butcher, Michael Bain; Diller, Phillip M.; Oparil, Suzanne; Calhoun, David; Brautigam, Donald; Flack, John; Goldman, Jesse M.; Rashidi, Arash; Aslam, Nabeel; Haley, William; Andrawis, Nabil; Lang, Brian; Miller, Randy; Powell, James; Dewhurst, Robert; Pritchard, James; Khanna, Dinesh; Tang, Dennis; Gabra, Nashwa; Park, Jean; Jones, Conigliaro; Scott, Cranford; Luna, Blanca; Mussaji, Murtaza; Bhagwat, Ravi; Bauer, Michael; McGinty, John; Nambiar, Rajesh; Sangrigoli, Renee; Davis, William Ross; Eaves, William; McGrew, Frank; Awad, Ahmed; Bolster, Eric; Scott, David; Kalirao, Paramjit; Dabel, Pascal; Calhoun, Wesley; Gouge, Steven; Warren, Mark; Lawrence, Mary Katherine; Jamal, Aamir; El-Shahawy, Mohamed; Mercado, Carlos; Kumar, Jayant; Velasquez-Mieyer, Pedro; Busch, Robert; Lewis, Todd; Rich, Lisa
Source
The Lancet; December 2022, Vol. 400 Issue: 10367 p1927-1937, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension.