학술논문
Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial
Document Type
Article
Author
Delany-Moretlwe, Sinead; Hughes, James P; Bock, Peter; Ouma, Samuel Gurrion; Hunidzarira, Portia; Kalonji, Dishiki; Kayange, Noel; Makhema, Joseph; Mandima, Patricia; Mathew, Carrie; Spooner, Elizabeth; Mpendo, Juliet; Mukwekwerere, Pamela; Mgodi, Nyaradzo; Ntege, Patricia Nahirya; Nair, Gonasagrie; Nakabiito, Clemensia; Nuwagaba-Biribonwoha, Harriet; Panchia, Ravindre; Singh, Nishanta; Siziba, Bekezela; Farrior, Jennifer; Rose, Scott; Anderson, Peter L; Eshleman, Susan H; Marzinke, Mark A; Hendrix, Craig W; Beigel-Orme, Stephanie; Hosek, Sybil; Tolley, Elizabeth; Sista, Nirupama; Adeyeye, Adeola; Rooney, James F; Rinehart, Alex; Spreen, William R; Smith, Kimberly; Hanscom, Brett; Cohen, Myron S; Hosseinipour, Mina C; Asmelash, Aida; Sehurutshi, Alice; Baguma, Allan; Marais, Anita; Kawoozo, Barbarah; Malinga, Bongiwe Prudence; Mirembe, Brenda Gati; Okech, Brenda; Esterhuizen, Bryan; Murombedzi, Caroline; Gadama, Daphne; Hwengwere, Eldinah; Roos, Elizabeth; Magada, Elizabeth S; Shava, Emily; Piwowar-Manning, Estelle; Tahuringana, Eunice; Muhlanga, Felix GS; Conradie, Francesca; Angira, Frank; Nanyonjo, Gertrude; Kistnasami, Girisha; Mvula, Hazzie; Naidoo, Ishana; Horak, Jaco; Jere, Jane; Moodley, Jeeva; Shin, Katie; Nel, Kerry; Bokoch, Kevin; Birungi, Lilian; Emel, Lynda; Monametsi, Maletsatsi; Sibanda, Marvelous; Mutambanengwe, Mercy; Chitukuta, Miria; Matimbira, Moleen; Bhondai-Mhuri, Muchaneta; Sibisi, Ncamsile; Morar, Neetha; Mudzonga, Netsai; Natureeba, Paul; Richardson, Paul; Musara, Petina; Macdonald, Pippa; Nkambule, Rejoice; Mosime, Repelang; White, Rhonda; Berhanu, Ribka; Ncube-Sihlongonyane, Ritha; Sekabira, Rogers; Siva, Samantha; Pillay, Saresha; Govender, Shamelle; Bamweyana, Sheiala; Nzimande, Siyabonga; Innes, Steve; Dadabhai, Sufia; Samandari, Taraz; Tembo, Tchangani; Lungu Mabedi, Thandie; Chirenda, Thandiwe; Chidemo, Tinashe; Mudhune, Victor; Naidoo, Vikesh; Samaneka, Wadzanai; Agyei, Yaw; Musodza, Yeukai; Fourie, Yolandie; Gaffoor, Zakir
Source
The Lancet; May 2022, Vol. 399 Issue: 10337 p1779-1789, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Oral pre-exposure prophylaxis has been introduced in more than 70 countries, including many in sub-Saharan Africa, but women experience considerable barriers to daily pill-taking, such as stigma, judgement, and the fear of violence. Safe and effective long-acting agents for HIV prevention are needed for women. We aimed to evaluate the safety and efficacy of injectable cabotegravir compared with daily oral tenofovir diphosphate plus emtricitabine (TDF-FTC) for HIV prevention in HIV-uninfected women.