학술논문
Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials
Document Type
Article
Author
Wykoff, Charles C; Abreu, Francis; Adamis, Anthony P; Basu, Karen; Eichenbaum, David A; Haskova, Zdenka; Lin, Hugh; Loewenstein, Anat; Mohan, Shaun; Pearce, Ian A; Sakamoto, Taiji; Schlottmann, Patricio G; Silverman, David; Sun, Jennifer K; Wells, John A; Willis, Jeffrey R; Tadayoni, Ramin; Aaberg, Thomas; Abbey, Ashkan; Abdulaeva, Elmira; Abengoechea, Santiago; Abraham, Prema; Ach, Thomas; Adams, Serrhel; Adan Civera, Alfredo; Adrean, Sean; Agostini, Hansjurgen; Alam, Suhail; Alezzandrini, Arturo; Alfaro, Virgil; Aliseda, Daniel; Almony, Arghavan; Amat, Pedro; Amini, Payam; Antoszyk, Andrew; Arias, Luis; Asaria, Riaz; Avila, Marcos; Awh, Carl C; Bafalluy, Joaquin; Baker, Carl; Bandello, Francesco; Barakat, Mark; Barraza, Karen; Bator, Gyorgy; Baumal, Caroline; Belfort Jr, Rubens; Bergstrom, Chris; Bertolucci, George; Bochow, Thomas; Bolz, Matthias; Borcz, Emilia; Bordon, Arnaldo; Boyer, David; Bratko, Galina; Brent, Michael; Brown, Jamin; Brown, David M; Budzinskaya, Maria; Buffet, Sylvia; Burgess, Stuart; Burton, Ben; Busquets, Miguel; Cabrera, Francisco; Cagini, Carlo; Calzada, Jorge; Campochiaro, Peter; Carlson, John; Castellarin, Alessandro; Cava, Carlos; Chaikitmongkol, Voraporn; Chan, Clement; Chang, Emmanuel; Chang, Jonathan; Chang, Andrew; Charles, Steve; Chaudhry, Nauman; Chee, Caroline; Chen, Judy; Chen, Fred; Chen, Shih-Jen; Cheong-Leen, Richard; Chiang, Allen; Chittum, Mark; Chow, David; Connolly, Brian; Cornut, Pierre Loic; Csaky, Karl; Danzig, Carl; Das, Arup; Daskalov, Vesselin; Desco, Carmen; Dessouki, Amr; Dickinson, John; Do, Brian; Dollin, Michael; Dugel, Pravin; Dusova, Jaroslava; Eichenbaum, David; Eldem, Bora; Engstrom, Robert; Ernest, Jan; Escobar, Joan Josep; Esposti, Simona; Eter, Nicole; Falk, Naomi; Farkas, Andrej; Feiner, Leonard; Feltgen, Nicolas; Fernandez, Carlos; Fernandez Vega, Alvaro; Ferrone, Philip; Figueira, Joao; Figueroa, Marta; Findl, .Oliver; Fine, Howard; Fortun, Jorge; Fox, Gregory M; Foxman, Scott; Framme, Carsten; Fraser-Bell, Samantha; Fu, Arthur; Fukutomi, Akira; Fung, Nicholas; Furno Sola, Federico; Gallego-Pinazo, Roberto; Garcia, Renata; Garcia-Layana, Alfredo; Gawecki, Maciej; George, Sheen; Ghanchi, Faruque; Ghorayeb, Ghassan; Goldberg, Roger; Goldstein, Michaella; Gomes, Nuno; Gomez Ulla, Francisco; Gonzalez, Victor; Greven, Craig; Gupta, Sunil; Guzman, Miguel; Harris, Martin; Hatz, Katja; Hau, Vivienne; Hau, Vincent; Hayashi, Ken; Heier, Jeffrey; Herba, Ewa; Hershberger, Vrinda; Higgins, Patrick; Hirakata, Akito; Ho, Allen; Holekamp, Nancy; Honda, Shigeru; Hsu, Jason; Hu, Allen; Hurcikova, Maria; Ikeda, Yasuhiro; Isernhagen, Ricky; Ito, Yasuki; Jackson, Tim; Jacoby, Rachael; Jafree, Afsar; Javey, Golnaz; Javid, Cameron; Jhaveri, Chirag; Johnson, Mark; Kacerík, Marek; Kaluzny, Jakub; Kampik, Daniel; Kang, Se Woong; Kapoor, Kapil; Karabas, Levent; Kawasaki, Tsutomu; Kerenyi, Agnes; Khanani, Arshad; Khurana, Rahul; Kim, Brian; Kimura, Kazuhiro; Kishino, Genichiro; Kitano, Shigehiko; Klein-Mascia, Kendra; Kokame, Gregg; Korobelnik, Jean Francois; Kulikov, Alexey; Kuriyan, Ajay; Kwong, Henry; Kwun, Robert; Lai, Timothy; Lai, Chi-Chun; Laird, Philip; Lalonde, Laurent; Lanzetta, Paolo; Larsen, Michael; Laugesen, Caroline; Lavinsky, Daniel; Lebreton, Olivier; Lee, Seong; Levy, Jaime; Lipkova, Blandina; Liu, Mimi; Liu, Judy; Lohmann, Chris P; London, Nikolas; Lorenz, Katrin; Lotery, Andrew; Lozano Rechy, David; Lujan, Silvio; Ma, Patrick; Maeno, Takatoshi; Mahmood, Sajjad; Makkouk, Fuad; Malik, Khurram; Marcus, Dennis; Margherio, Alan; Mastropasqua, Leonardo; Maturi, Raj; McCabe, Frank; McKibbin, Martin; Mehta, Hemal; Menon, Geeta; Mentes, Jale; Michalska-Malecka, Katarzyna; Misheva, Aneta; Mitamura, Yoshinori; Mitchell, Paul; Modi, Yasha; Mohamed, Quresh; Montero, Javier; Moore, Jeffrey; Morales Canton, Virgilio; Morori-Katz, Haia; Morugova, Tatiana; Murakami, Tomoaki; Muzyka-Wozniak, Maria; Nardi, Marco; Nemcansky, Jan; Nester-Ostrowska, Kamila; Neto, Julio; Newell, Charles; Nicolo, Massimo; Nielsen, Jared; Noda, Kousuke; Obana, Akira; Ogata, Nahoko; Oh, Hideyasu; Oh, Kean; Ohr, Matthew; Oleksy, Piotr; Oliver, Scott; Olivier, Sebastien; Osher, James; Ozcalişkan, Sehnaz; Ozturk, Banu; Papp, Andras; Park, Kyu Hyung; Parke, D Wilkin; Parravano, Maria Cristina; Patel, Sugat; Patel, Sunil; Pearce, Ian; Pearlman, Joel; Penha, Fernando; Perente, Irfan; Perkins, Stephen; Pertile, Grazia; Petkova, Iva; Peto, Tunde; Pieramici, Dante; Pollreisz, Andreas; Pongsachareonnont, Pear; Pozdeyeva, Nadezhda; Priglinger, Siegfried; Qureshi, Jawad; Raczynska, Dorota; Rajagopalan, Rajesh; Ramirez Estudillo, Juan; Raskauskas, Paul; Rathod, Rajiv; Razavi, Hessam; Regillo, Carl; Ricci, Federico; Rofagha, Soraya; Romanczak, Dominika; Romanowska-Dixon, Bożena; Rosberger, Daniel; Rosenblatt, Irit; Rosenblatt, Brett; Ross, Adam; Ruamviboonsuk, Paisan; Ruiz Moreno, Jose Maria; Salomão, Gustavo; Sandhu, Sukhpal; Sandner, Dirk; Sararols, Laura; Sawada, Osamu; Schadlu, Ramin; Schlottmann, Patricio; Schuart, Claudia; Seitz, Berthold; Seres, András; Sermet, Figen; Shah, Sandeep; Shah, Ankur; Shah, Rohan; Sharma, Sumit; Sheidow, Thomas; Sheth, Veeral; Shimouchi, Akito; Shimura, Masahiko; Sikorski, Bartosz; Silva, Rufino; Singer, Michael; Singerman, Lawrence; Singh, Rishi; Souied, Eric; Spinak, David J; Spital, Georg; Steinle, Nathan; Stern, Jeffrey; Stoller, Glenn; Stoltz, Robert; Stone, Cameron; Stone, Amy; Suan, Eric; Sugimoto, Masahiko; Sugita, Iichiro; Sun, Jennifer; Sun, Xiaodong; Suner, Ivan; Szalczer, Lajos; Szecsko, Timea; Tabassian, Ali; Tadayoni, Ramin; Takagi, Hitoshi; Takayama, Kei; Taleb, Alexandre; Talks, James; Tan, Gavin; Tanabe, Teruyo; Taylor, Stanford; Thach, Allen; Thompson, John; Tlucek, Paul; Torti, Robert; Tosheva Guneva, Daniela; Toth-Molnar, Edit; Uchiyama, Eduardo; Vajas, Attila; Varma, Deepali; Varsanyi, Balazs; Vassileva, Petja; Vaz-Pereira, Sara; Veith, Miroslav; Vela, Jose Ignacio; Viola, Francesco; Virgili, Gianni; Vogt, Gábor; Vorum, Henrik; Weber, Pamela; Wecke, Thoalf; Wee, Raymond; Weger, Martin; Weishaar, Paul; Wells, John A; Wickremasinghe, Sanjeewa; Williams, Thomas Reginald; Williams, Thomas; Williams, Geoff; Wolf, Armin; Wolfe, Jeremy; Wong, James; Wong, David; Wong, Ian; Wong, Robert; Wowra, Bogumil; Wykoff, Charles C; Wylęgała, Edward; Yang, Chang-Hao; Yasukawa, Tsutomu; Yates, Paul; Yilmaz, Gursel; Yiu, Glenn; Yoon, Young Hee; Yoreh, Barak; Yoshida, Shigeo; Yu, Hyeong Gon; Yu, Seung Young; Yurieva, Tatiana; Zacharias, Leandro; Zaczek Zakrzewska, Karolina; Zambrano, Alberto; Zatorska, Barbara; Zeolite, Carlos; Zheutlin, Jeffrey
Source
The Lancet; February 2022, Vol. 399 Issue: 10326 p741-755, 15p
Subject
Language
ISSN
01406736; 1474547X
Abstract
To reduce treatment burden and optimise patient outcomes in diabetic macular oedema, we present 1-year results from two phase 3 trials of faricimab, a novel angiopoietin-2 and vascular endothelial growth factor-A bispecific antibody.