학술논문
A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial
Document Type
Article
Author
Landman, Roland; de Truchis, Pierre; Assoumou, Lambert; Lambert, Sidonie; Bellet, Jonathan; Amat, Karine; Lefebvre, Bénédicte; Allavena, Clotilde; Katlama, Christine; Yazdanpanah, Yazdan; Molina, Jean-Michel; Petrov-Sanchez, Ventzislava; Gibowski, Séverine; Alvarez, Jean C; Leibowitch, Jacques; Capeau, Jacqueline; Fellahi, Soraya; Duracinsky, Martin; Morand-Joubert, Laurence; Costagliola, Dominique; Alvarez, Jean-Claude; Girard, Pierre-Marie; LAMAURY, Isabelle; BANI-SADR, Firouzé; FORCE, Gilles; CHABROL, Amélie; CABY, Fabienne; PATEY, Olivier; FRESARD, Anne; GAGNEUX-BRUNON, Amandine; CHIROUZE, Catherine; DUVIVIER, Claudine; LOURENCO, Jérémie; TOLSMA, Violaine; JANSSEN, Cécile; LEROLLE, Nathalie; CATALAN, Pilartxo; RAMI, Agathe; DE PONTHAUD, Lucile; PICHANCOURT, Gilles; NASRI, Safa; LANDOWSKI, Stéphanie; BOTTERO, Julie; MFUTILA KAYKAY, Flory; PIALOUX, Gilles; BOUCHAUD, Olivier; ABGRALL, Sophie; GATEY, Caroline; WEISS, Laurence; PAVIE, Juliette; SALMON-CERON, Dominique; ZUCMAN, David; LELIEVRE, Jean-Daniel; PALICH, Romain; SIMON, Anne; MEYOHAS, Marie-Caroline; GRAS, Julien; CABIE, André; PIRCHER, Mathilde; MORLAT, Philippe; HESSAMFAR, Mojgam; NEAU, Didier; CAZENAVE, Charles; GENET, Claire; FAUCHER, Jean-François; MAKHLOUFI, Djamila; BOIBIEUX, André; BREGIGEON-RONOT, Sylvie; LAROCHE, Hélène; SAUTEREAU, Aurélie; REYNES, Jacques; MAKINSON, Alain; RAFFI, François; BOLLENGIER-STRAGIER, Olivier; NAQVI, Alissa; CUA, Eric; ROSENTHAL, Eric; ARVIEUX, Cédrick; BUZELE, Rodolphe; REY, David; BATARD, Marie-Laure; BERNARD, Louis; DELOBEL, Pierre; PIFFAUT, Marie; VERDON, Renaud; PIROTH, Lionel; BLOT, Mathieu; LECLERCQ, Pascale; SIGNORI-SCHMUCK, Anne; HULEUX, Thomas; MEYBECK, Agnès; MAY, Thierry; MIAILHES, Patrick; PERPOINT, Thomas; GREDER-BELAN, Alix; ELHARRAR, Brigitte; KHUONG, Marie-Aude; POUPARD, Marie; BLUM, Laurent; MICHAU, Christophe; PRAZUCK, Thierry; PHILIBERT, Patrick; SLAMA, Laurence; HIKOMBO, Hitoto; DARASTEANU, Iuliana; GIRARD, Pierre-Marie; ALVAREZ, Jean-Claude; MATHEZ, Dominique; DE TRUCHIS, Pierre; LANDMAN, Roland; MEYNARD, Jean-Luc; MORAND-JOUBERT, Laurence; LAMBERT, Sidonie; LE DU, Damien; PERRONNE, Christian; ASSOUMOU, Lambert; COSTAGLIOLA, Dominique; MELCHIOR, Jean-Claude; DURACINSKI, Martin; PETROV-SANCHEZ, Ventzislava; AMAT, Karine; BENALYCHERIF, Aïda; SYLLA, Babacar; GELLEY, Ambre; GIBOWSKI, Séverine; LE MEUT, Guillaume; THIEBAUT, Rodolphe; CLUMECK, Nathan; LECLERCQ, Vincent; CECCHERINI-SILBERSTEIN, Francesca; DECOSTER, Laurent; LAMAURY, Isabelle; BANI-SADR, Firouzé; FORCE, Gilles; CHABROL, Amélie; CABY, Fabienne; PATEY, Olivier; FRESARD, Anne; GAGNEUX-BRUNON, Amandine; CHIROUZE, Catherine; DUVIVIER, Claudine; LOURENCO, Jérémie; TOLSMA, Violaine; JANSSEN, Cécile; LEROLLE, Nathalie; CATALAN, Pilartxo; RAMI, Agathe; DE PONTHAUD, Lucile; PICHANCOURT, Gilles; NASRI, Safa; LANDOWSKI, Stéphanie; BOTTERO, Julie; MFUTILA KAYKAY, Flory; PIALOUX, Gilles; BOUCHAUD, Olivier; ABGRALL, Sophie; GATEY, Caroline; WEISS, Laurence; PAVIE, Juliette; SALMON-CERON, Dominique; ZUCMAN, David; LELIEVRE, Jean-Daniel; PALICH, Romain; SIMON, Anne; MEYOHAS, Marie-Caroline; GRAS, Julien; CABIE, André; PIRCHER, Mathilde; MORLAT, Philippe; HESSAMFAR, Mojgam; NEAU, Didier; CAZENAVE, Charles; GENET, Claire; FAUCHER, Jean-François; MAKHLOUFI, Djamila; BOIBIEUX, André; BREGIGEON-RONOT, Sylvie; LAROCHE, Hélène; SAUTEREAU, Aurélie; REYNES, Jacques; MAKINSON, Alain; RAFFI, François; BOLLENGIER-STRAGIER, Olivier; NAQVI, Alissa; CUA, Eric; ROSENTHAL, Eric; ARVIEUX, Cédrick; BUZELE, Rodolphe; REY, David; BATARD, Marie-Laure; BERNARD, Louis; DELOBEL, Pierre; PIFFAUT, Marie; VERDON, Renaud; PIROTH, Lionel; BLOT, Mathieu; LECLERCQ, Pascale; SIGNORI-SCHMUCK, Anne; HULEUX, Thomas; MEYBECK, Agnès; MAY, Thierry; MIAILHES, Patrick; PERPOINT, Thomas; GREDER-BELAN, Alix; ELHARRAR, Brigitte; KHUONG, Marie-Aude; POUPARD, Marie; BLUM, Laurent; MICHAU, Christophe; PRAZUCK, Thierry; PHILIBERT, Patrick; SLAMA, Laurence; HIKOMBO, Hitoto; DARASTEANU, Iuliana; GIRARD, Pierre-Marie; ALVAREZ, Jean-Claude; MATHEZ, Dominique; DE TRUCHIS, Pierre; LANDMAN, Roland; MEYNARD, Jean-Luc; MORAND-JOUBERT, Laurence; LAMBERT, Sidonie; LE DU, Damien; PERRONNE, Christian; ASSOUMOU, Lambert; COSTAGLIOLA, Dominique; MELCHIOR, Jean-Claude; DURACINSKI, Martin; PETROV-SANCHEZ, Ventzislava; AMAT, Karine; BENALYCHERIF, Aïda; SYLLA, Babacar; GELLEY, Ambre; GIBOWSKI, Séverine; LE MEUT, Guillaume; THIEBAUT, Rodolphe; CLUMECK, Nathan; LECLERCQ, Vincent; CECCHERINI-SILBERSTEIN, Francesca; DECOSTER, Laurent
Source
The Lancet HIV; February 2022, Vol. 9 Issue: 2 pe79-e90, 12p
Subject
Language
ISSN
24054704; 23523018
Abstract
Intermittent (on 4 days per week) antiretroviral therapy (ART) for patients with HIV-1 might be more convenient, better tolerated, and cheaper than continuous treatment. We aimed to establish the efficacy and safety of a 4-days-on and 3-days-off (intermittent) maintenance regimen versus a standard 7 day (continuous) maintenance regimen.