학술논문
Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial
Document Type
Article
Author
Toback, Seth; Galiza, Eva; Cosgrove, Catherine; Galloway, James; Goodman, Anna L; Swift, Pauline A; Rajaram, Sankarasubramanian; Graves-Jones, Alison; Edelman, Jonathan; Burns, Fiona; Minassian, Angela M; Cho, Iksung; Kumar, Lakshmi; Plested, Joyce S; Rivers, E Joy; Robertson, Andreana; Dubovsky, Filip; Glenn, Greg; Heath, Paul T; Soiza, Roy L.; Brittain-Long, Robin; Scicluna, Chiara; Edwards, Carole; Mackay, Lynn; D'Allesandro, Mariella; Nicol, Amy; Norris, Karen; Mann, Sandra; Lawrence, Heather; Valentine, Ruth; Viljoen, Marianne Elizabeth; Pretswell, Carol H.; Nicholls, Helen; Munsoor, Imrozia; Meyrick, Agnieszka; Kyriakidou, Christina; Iyengar, Shalini; Jamal, Arham; Richards, Nick; Price, Helen; Rowbotham, Bridie; Bird, Danielle; Smith, Karen; Littler, Olga; Fielding, Kirsty; Townsend-Rose, Anna; Miller, Karen; Davis, Jessica; Elliot-Garwood, Alison; Trottier, Lauren; Edwards, Paul; McFarland, Margaret; Osanlou, Orod; Longshaw, Laura; Stockport, Jane; Grundy, Lynne; Broad, Katharine Lucy; Regan, Karen; Storton, Kim; Ryan-Wakeling, Declan; Wilson, Brad; Munisamy, Malathy; Wright, John; Shenoy, Anil; English, Beverley; Brear, Lucy; Cicconi, Paola; Boffito, Marta; Milinkovic, Ana; Byrne, Ruth; Movahedi, Roya; Housman, Rosalie; Kara, Naveed; Brown, Ellen; Cipriani, Andrea; Attenburrow, Mary-Jane; Smith, Katharine A.; Packham, Jonathan; Sparrow, Geoff; Smith, Richard; Rosier, Josephine M.; Saja, Khalid; Nago, Nyasha; Camilleri, Brian; Immanuel, Anita; Hamblin, Mike; Osagie, Rawlings; Mohan, Mahalakshmi; Floyd, Hilary; Goddard, Suzanne; Mutgi, Sanjay; Evans, John; McKeon, Sean; Vilimiene, Neringa; Chicano, Rosavic; Hayre, Rachel; Pandaan, Alice; Henshall, Catherine; Serrano, Sonia; Mazzella, Andrea; Rajeswaran, Thurkka; Mathew, Moncy; Bisnauthsing, Karen; Bremner, Laura; Fok, Henry; Morselli, Franca; Cinardo, Paola; Merrick, Blair; Sowole, Lucy; Broadhead, Samantha; Palmer, Natalie; Cordle, Jessica; Goldsmith, Jaimie Wilson; Cooney, Enya; Jackson, Beth; Jayatilleke, Thilina; Cheng, Zelda; Helliwell, Toby; Chudyk, Adrian; Giemza, Rafaela; Villajin, John Lord; Yogo, Noah; Makanju, Esther; Dulawan, Pearl; Nagra, Deepak; Buazon, April; Russell, Alice; Bird, Georgie; Heer, Amardeep; Sarmiento, Rex; Sanghera, Balraj; Mullin, Melanie; Champion, Adam; Bevan, Aisling; Iqbal, Kinzah; Johnson, Alshia; Clark, Rebecca; Shaw, Sarah; Shaw, Steven; Chalk, Amanda; Lovatt, Martin; Lillicrap, Caroline; Parker, Angela; Hansel, Jan; Wong, Zhi; Gan, Galvin; Tuma, Eyad; Minton, Jane; Murira, Jennifer; Saman, Razan; Hall, Alistair; Holliday, Kyra; Khan, Zara; Calderwood, James; Twigg, George; Baker, Helena; Corrigan, Julie; Houseman, Katy; Raguvanshi, Subhra; Heining, Dominic; Weddell, Jake; Glaves, Liz; Thompson, Kim; Davies, Francis; Lambley Burke, Ruth; Thomson, Emma C.; Saralaya, Dinesh; Berry, Lisa; Hopewell, Nancy; Gerdes, Leigh; Pacurar, Mihaela; Faust, Saul N.; Turner, Jeremy; Jeanes, Christopher; Cooper, Adele; Keshet-Price, Jocelyn; Coke, Lou; Cambell-Kelly, Melissa; Dhatariya, Ketan; Williams, Claire; Marks, Georgina; Sudbury, James; Rodolico, Lisa; Bradley, Judy; Carr, Sharon; Martin, Roisin; Madden, Angelina; Biagioni, Paul; McKenna, Sonia; Clinton, Alison; O'Kane, Maurice; Carter, Justin; Dewhurst, Matthew; Wetherill, Bill; Hoggarth, Thandiwe; Collins, Katrina Lennon; Chowdhury, Marie; Nathoo, Adil; Heinen, Anna; MacDonald, Orla; Hurducas, Claudia; Cifuentes, Liliana; Gill, Harjeevan; Gibson, Andy; West, Raha; Ewing, Jane; Blacow, Rachel; Haughney, John; MacDonald, Jonathan; Seenan, John Paul; Webb, Stewart; O'Leary, Colin; Muir, Scott; White, Beth; Ritchie, Neil; McAuley, Daniel F.; Stewart, Jonathan; D'Alessandro, Mariella; Lakeman, Nicki; Purandare, Laura; Browne, Duncan; Tucker, David; Luck, Peter; Everden, Angharad; Trembath, Lisa; Visick, Michael; Morley, Nick; Reid, Laura; Chenoweth, Helen; Maclean, Kirsty; Sheridan, Ray P.; Burden, Tom; Lunt, Craig Francis; Todd, Shirley; Estcourt, Stephanie; Pearce, Jasmine Marie; Wilkins, Suzanne; Love-Rouse, Cathryn; Torok-Pollok, Eva; Youle, Mike; Madge, Sara; Solomon, Danielle; Nandani, Aarti; North, Janet M.; Hemat, Nargis; Newport, Rachel; Kalra, Philip A.; Chukwu, Chukwuma; Wickens, Olivia; O'Loughlin, Vikki; Mistry, Hema; Harrison, Louise; Oliver, Robert; Peers, Anne-Marie; Zadik, Jess; Doyle, Katie; Chadwick, David R.; Colling, Kerry; Wroe, Caroline; Branch, Marie; Chilvers, Alison; Essex, Sarah; Stone, Mark; San Francisco Ramos, Alberto; Beales, Emily; Bird, Olivia; Danos, Zsofia; Fofie, Hazel; Hultin, Cecilia; Ikram, Sabina; Mabesa, Fran; Mescall, Aoife; Pereira, Josyanne; Pearce, Jennifer; Sutton, Natalina; Snashall, Emma; Baxter, David Neil; Bennett, Sara; Suggitt, Debbie; Hughes, Kerry; Woodyatt, Wiesia; Beacon, Lynsey; Kent, Alissa; Cooper, Chris; Rudic, Milan; Tunstall, Simon; Jackson, Matthew; Hombersley, Claire; Moore, Patrick; Cutts, Rebecca; Higham, Andrew; Bukhari, Marwan; Elnaggar, Mohamed; Glover, Michelle; Richardson, Fiona; Dent, Alexandra; Mirza, Shahzeb; Ark, Rajiv; Han, Jennie; Hope, Suzy V.; Mitchelmore, Philip J.; Osanlou, Rostam; Freedman, Andrew; Cooper, Alison; Burton, Katherine; Katechia, Kashyap; Barrett, Michael; Salkeld, Jo; Hill, Natalie; Lee, Nathaniel; Perkins, Jon; Fox, Polly
Source
The Lancet Respiratory Medicine; 20210101, Issue: Preprints
Subject
Language
ISSN
22132600; 22132619
Abstract
The safety and immunogenicity profile of COVID-19 vaccines when administered concomitantly with seasonal influenza vaccines have not yet been reported. We therefore aimed to report the results of a substudy within a phase 3 UK trial, by evaluating the safety, immunogenicity, and efficacy of NVX-CoV2373 when co-administered with licensed seasonal influenza vaccines.