학술논문
Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials
Document Type
Article
Author
Rubin, David T; Dotan, Iris; DuVall, Aaron; Bouhnik, Yoram; Radford-Smith, Graham; Higgins, Peter D R; Mishkin, Daniel S; Arrisi, Pablo; Scalori, Astrid; Oh, Young S; Tole, Swati; Chai, Akiko; Chamberlain-James, Kirsten; Lacey, Stuart; McBride, Jacqueline; Panés, Julian; Rustem, Abdulkhakov; Norasiah, Abu Bakar; Humberto, Aguilar; Diego, Aizenberg; Hale, Akpinar; Evangelos, Akriviadis; Olga, Alexeeva; Bagdadi, Alikhanov; Andres, Alvarisqueta; Ashwin, Ananthakrishnan; Jane, Andrews; Tomasz, Arlukowicz; Nathan, Atkinson; Ozlen, Atug; Mauro, Bafutto; Jozef, Balaz; George, Bamias; Marko, Banic; Andrey, Baranovsky; Guerino, Barbalaco Neto; Metin, Basaranoglu; Curtis, Baum; Stefan, Baydanov; William, Bennetts; Fatih, Besisik; Sudhir, Bhaskar; Andrzej, Bielasik; Leonid, Bilianskyi; Bahri, Bilir; Pavol, Blaha; Verle, Bohman; Julia, Borissova; Vladimir, Borzan; Francisco, Bosques-Padilla; Yoram, Bouhnik; James, Brooker; Tetiana, Budko; Igor, Budzak; Ivan, Bunganic; Jonathon, Chapman; Azlida, Che' Aun; Tatiana, Chernykh; Michael, Chiorean; Ivan, Chopey; Dimitrios, Christodoulou; Pui Shan, Chu; Galina, Chumakova; Andrew, Cummins; Robert, Cunliffe; Mirjana, Cvetkovic; Ulku, Dagli; Wit Cezary, Danilkiewicz; Olena, Datsenko; Carlos Fernando, de Magalhães Francesconi; Henry, Debinski; Elena, Deminova; Jelena, Derova; John Nik, Ding; Julia, Dmitrieva; Oleg, Dolgikh; Tomas, Douda; Piotr, Drobinski; Gerald, Dryden; Pedro, Duarte Gaburri; George Aaron, DuVall; Mikhail, Dvorkin; Craig, Ennis; Yusuf, Erzin; Galyna, Fadieienko; Oleksandr, Fediv; Olga, Fedorishina; Miroslav, Fedurco; Roland, Fejes; Jorge, Fernandez; Monica Lorena, Fernandez; Lucky, Flores; Bradley, Freilich; Keith, Friedenberg; Sergio, Fuster; Beata, Gawdis-Wojnarska; Fabio Leonel, Gil Parada; Edgardo Daniel, Gimenez; Nataliia, Golovchenko; Oleksandr, Golovchenko; Maciej, Gonciarz; Can, Gonen; Glenn, Gordon; Milos, Gregus; Vladimir, Grinevich; Rogelio, Guajardo Rodriguez; Stephen, Hall; John, Hanson; Marek, Hartleb; Xavier, Hebuterne; Peter, Hendy; Robert, Herring; David, Hetzel; Peter, Higgins; Raouf, Hilal; Ida Normiha, Hilmi; Tibor, Hlavaty; Richard, Holman; Gerald, Holtmann; John, Hong; Frantisek, Horvath; Ihor, Hospodarskyy; Irena, Hrstic; Sadettin, Hulagu; Luis Alberto, Ibarra Verdugo; Ikechukwu, Ibegbu; Stephen, Inns; Vladimir, Ivashkin; James, Izanec; Rajesh, Jain; Zofia, Jamrozik-Kruk; Victor, Kamburov; John, Karagiannis; Tarkan, Karakan; Marek, Karczewski; Irina, Kasherininova; Seymour, Katz; Barry, Kaufman; Edita, Kazenaite; Irina, Kholina; Sunil, Khurana; Jaroslaw, Kierkus; Anzela, Kiselevska; Dariusz, Kleczkowski; Volodymyr, Klymenko; Slavko, Knezevic; Malgorzata, Kondusz-Szklarz; Natalya, Korablina; Bartosz, Korczowski; Lyubomir, Kosturkov; Iskren, Kotzev; Georgios, Kouklakis; Ioannis, Koutroubakis; Richard, Krause; Ian, Kronborg; Miodrag, Krstic; Zeljko, Krznaric; Mikolaj, Krzyzanowski; Grazyna, Kulig; Karin, Kull; Limas, Kupcinskas; Mark, Lamet; Tatjana, Latinovic Radakovic; Rupert, Leong; Wai Keung, Leung; Henry, Levine; Michael Kin Kong, Li; Lúcia, Libanez Bessa Campelo Braga; Maria, Livzan; Tetiana, Lohdanidi; Maria Helena, Louzada Pereira; John, Lowe; Kresimir, Luetic; Milan, Lukas; Yurii, Lymar; Finlay, Macrae; Anu, Mäelt; Igor, Maev; Arkadiusz, Mamos; Gerasimos, Mantzaris; Benno, Margus; Ivanka, Marinova; Inna, Markevych; Mario, Markov; Srdjan, Markovic; Juan Ricardo, Marquez Velasquez; Felipe, Mazzoleni; Konstantinos, Mimidis; Brent, Mitchell; Gregory, Moore; Luis Alonso, Morales Garza; Salvatore, Moscatello; Yuriy, Mostovoy; Reme, Mountifield; Aleksandar, Nagorni; Viacheslav, Neshta; Andrey, Obrezan; Oleksandr, Oliinyk; Genoile, Oliveira Santana Silva; Maria, Orzeszko; Vladimir, Pavlenko; Dimitar, Pavlov; Mariana, Penkova; Sasa, Peric; Plamen, Petkov; Asen, Petrov; Plamen, Petrov; Michaela, Petrova; Raymond, Phillips; Sergio, Pintor Chacon; Igor, Polianskyi; Ludmyla, Prystupa; Mykhailo, Pugach; Ana Teresa, Pugas Carvalho; Aldis, Pukitis; Jiri, Pumprla; Volodymyr, Pyrogovskyy; Istvan, Racz; Graham, Radford-Smith; Raja Affendi, Raja Ali; Daniel, Ramos Castañeda; Odery, Ramos Júnior; David, Rausher; Andrey, Rebrov; Jaroslaw, Regula; Amir, Rezk; Viktoriia, Reznikova; Iaroslava, Rishko; Xavier, Roblin; Grigory, Rodoman; Carlos Arturo, Rojas Rodriguez; Jerzy, Rozciecha; David, Rubin; Maciej, Rupinski; Jacek, Rzucidlo; Oleg, Sablin; Halil, Sahin; Rosemi, Salleh; Douglas, Samuel; Antonio, Scafuto Scotton; Robert, Schnabel; Michael, Schulman; Michael, Schultz; John, Scott; Shahriar, Sedghi; Ahmad, Shaban; Marina, Shapina; Natalia, Shaposhnikova; Oksana, Shchukina; Alex, Sherman; Irina, Shumikhina; Vladimir, Simanenkov; Vladislav, Simonov; Giedrius, Simulionis; Igor, Skrypnyk; Zbigniew, Sliwowski; Jan, Smid; Mahmood, Solaiman; Najm, Soofi; Konstantinos, Soufleris; Zoia, Spassova; Mykola, Stanislavchuk; Krystyna, Stec-Michalska; Jonathas, Stifft; Simeon, Stoinov; Girgina, Stoyanova; Keith, Sultan; Lindsey, Surace; Dimitar, Takov; Jaak, Tälli; Ludmila, Tankova; Hugo, Tanno; Dino, Tarabar; Elias, Tarakji; Konstantin, Tchernev; Hoi Poh, Tee; Lena, Thin; Carlton, Thomas; Irina, Tishaeva; Tsveta, Todorova; Oleksandr, Tokarenko; Ivars, Tolmanis; Ratko, Tomasevic; Vasiliy, Trofimov; Zsolt, Tulassay; Belkis, Unsal; Alma, Uzunova-Genova; John, Valentine; Ekaterina, Valuyskikh; Eduardo, Vasconcellos; Galina, Vasileva; Sergiy, Vasylyuk; Byron, Vaughn; Francisco, Velazquez; Vadym, Vizir; Borislav, Vladimirov; Miroslava, Volfova; Petr, Vyhnalek; Ian, Wallace; Marek, Waluga; William, Watkins; John, Weber; Anna, Wiechowska-Kozlowska; Nathaniel, Winstead; Pawel, Wojtkiewicz; Barbara, Wozniak-Stolarska; Bruce, Yacyshyn; Alexey, Yakovlev; Ziad, Younes; Lígia, Yukie Sassaki; Ilhami, Yuksel; Jan, Zachar; Cyrla, Zaltman; Natasa, Zdravkovic Petrovic; Vyacheslav, Zhdan; Maryna, Zinchenko; Maciej, Zymla
Source
The Lancet Gastroenterology & Hepatology; January 2022, Vol. 7 Issue: 1 p17-27, 11p
Subject
Language
ISSN
24681253
Abstract
Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In an earlier phase 2 induction study, etrolizumab significantly improved clinical remission relative to placebo in patients with moderately to severely active ulcerative colitis. The HIBISCUS studies aimed to compare the efficacy and safety of etrolizumab to adalimumab and placebo for induction of remission in patients with moderately to severely active ulcerative colitis.