학술논문
Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study
Document Type
Article
Author
Danese, Silvio; Colombel, Jean-Frederic; Lukas, Milan; Gisbert, Javier P; D'Haens, Geert; Hayee, Bu'hussain; Panaccione, Remo; Kim, Hyun-Soo; Reinisch, Walter; Tyrrell, Helen; Oh, Young S; Tole, Swati; Chai, Akiko; Chamberlain-James, Kirsten; Tang, Meina Tao; Schreiber, Stefan; Aboo, Nazimuddin; Ahmad, Tariq; Aldeguer Mante, Xavier; Allez, Matthieu; Almer, Sven; Altwegg, Romain; Andreu Garcia, Montserrat; Arasaradnam, Ramesh; Ardizzone, Sandro; Armuzzi, Alessandro; Arnott, Ian; Aumais, Guy; Avni-Biron, Irit; Barrow, Peter; Beales, Ian; Bermejo San Jose, Fernando; Bezuidenhout, Abraham; Biancone, Livia; Blaeker, Michael; Bloom, Stuart; Bokemeyer, Bernd; Bossa, Fabrizio; Bossuyt, Peter; Bouguen, Guillaume; Bouhnik, Yoram; Bouma, Gerd; Bourdages, Raymond; Bourreille, Arnaud; Boustiere, Christian; Brabec, Tomas; Brand, Stephan; Buening, Carsten; Buisson, Anthony; Cadiot, Guillaume; Calvet Calvo, Xavier; Carbonnel, Franck; Carpio, Daniel; Cheon, Jae Hee; Chiba, Naoki; Chioncel, Camelia; Cimpoeru, Nicoleta-Claudia; Clodi, Martin; Corazza, Gino Roberto; Cosintino, Rocco; Cotter, Jose; Creed, Thomas; Cummings, Fraser; Danese, Silvio; de' Angelis, Gian Luigi; De Maeyer, Marc; Desai, Milind; Desilets, Etienne; Desreumaux, Pierre; Dewit, Olivier; D'Haens, Geert; Dinter, Johanna; Dobru, Ecaterina Daniela; Douda, Tomas; Dumitrascu, Dan Lucian; Ebert, Matthias; Echarri Piudo, Ana; Elkhashab, Magdy; Eun, Chang Soo; Feagan, Brian; Fejes, Roland; Fidalgo, Catarina; Fishman, Sigal; Flourié, Bernard; Fowler, Sharyle; Fries, Walter; Fulop, Csaba; Fumery, Mathurin; G Kiss, Gyula; Gassner, Sonja; Gaya, Daniel; Germanà, Bastianello; Gheorghe, Liliana Simona; Gilletta de Saint Joseph, Cyrielle; Gionchetti, Paolo; Goldis, Adrian-Eugen; Gonçalves, Raquel; Grimaud, Jean-Charles; Gyökeres, Tibor; Hagege, Herve; Haidar, Andrei; Hartmann, Heinz; Hasselblatt, Peter; Hayee, Buhussain; Hebuterne, Xavier; Hellström, Per; Hindryckx, Pieter; Hlavova, Helena; Hoentjen, Frank; Howaldt, Stefanie; Hrdlicka, Ludek; Huh, Kyu Chan; Iborra Colomino, Maria Isabel; Ionita-Radu, Florentina; Irving, Peter; Jahnsen, Jørgen; Jang, ByungIk; Jansen, Jeroen; Jeon, Seong Woo; Jover Martinez, Rodrigo; Juillerat, Pascal; Karlén, Per; Kaser, Arthur; Keil, Radan; Kejariwal, Deepak; Keret, Dan; Khanna, Reena; Kim, Dongwoo; Kim, Duk Hwan; Kim, Hyo-Jong; Kim, Hyun-Soo; Kim, Joo Sung; Kim, Kueongok; Kim, Kyung-Jo; Kim, Sung Kook; Kim, Young-Ho; Klaus, Jochen; Kohn, Anna; Kojecky, Vladimir; Koo, Ja Seol; Kozak, Robert; Kremer, Milan; Kristof, Tunde; Kruger, Frederik; Laharie, David; Lahat-zok, Adi; Landa, Evgeny; Lee, Jonghun; Lee, Kang-Moon; Lee, Kook Lae; Lee, YooJin; Lenze, Frank; Lim, Wee Chian; Limdi, Jimmy; Lindsay, James; Lopez Serrano, Pilar; Louis, Edouard; Lueth, Stefan; Lukas, Milan; Maconi, Giovanni; Mana, Fazia; Mann, Steven; Mansfield, John; Marchi, Santino; Marino, Marco; Marshall, John; Martin Arranz, Maria Dolores; Mateescu, Radu-Bogdan; McLaughlin, John; McLaughlin, Simon; Melzer, Ehud; Mertens, Jessica; Mitrut, Paul; Molnar, Tamas; Muls, Vinciane; Munuswamy, Pushpakaran; Murray, Charles; Naftali, Timna; Naidoo, Visvakuren; Nanabhay, Yusuf; Negreanu, Lucian; Nguyen, Augustin; Ochsenkuehn, Thomas; Orlando, Ambrogio; Panaccione, Remo; Panes Diaz, Julian; Paritsky, Maya; Park, Dong Il; Park, Jihye; Pastorelli, Luca; Peck-Radosavljevic, Markus; Peerani, Farhad; Perez Gisbert, Javier; Peyrin-Biroulet, Laurent; Picon, Laurence; Pierik, Marieke; Ponich, Terry; Portela, Francisco; Prins, Maartens Jeroen; Racz, Istvan; Rahman, Khan Fareed; Reimund, Jean-Marie; Reinshagen, Max; Roblin, Xavier; Rocca, Rodolfo; Rogai, Francesca; Rogler, Gerhard; Salamon, Agnes; Salazar, Ennaliza; Sallo, Zoltan; Samuel, Sunil; Sans Cuffi, Miquel de los Santos; Savarino, Edoardo Vincenzo; Savarino, Vincenzo; Savoye, Guillaume; Schreiber, Stefan; Seicean, Andrada; Selinger, Christian; Serra, David Martins; Shim, Hang Hock; Shin, SungJae; Siegmund, Britta; Siffledeen, Jesse; Simmonds, Wayne; Smid, Jan; Sollano, Jose; Song, Geun Am; Speight, Alexander; Sporea, Ioan; Staessen, Dirk; Stancu, George; Steel, Alan; Stepek, David; Stoica, Victor; Sturm, Andreas; Szekely, Gyorgy; Tan, Teck Kiang; Taxonera Samso, Carlos; Thomson, John; Tichy, Michal; Toth, Gabor Tamas; Tulassay, Zsolt; Vangeli, Marcello; Varga, Marta; Vieira, Ana; Viennot, Stephanie; Villa, Erica; Vitek, Petr; Vogelsang, Harald; Vyhnalek, Petr; Wahab, Peter; Walldorf, Jens; Ye, Byong Duk; Ziady, Christopher
Source
The Lancet Gastroenterology & Hepatology; February 2022, Vol. 7 Issue: 2 p118-127, 10p
Subject
Language
ISSN
24681253
Abstract
Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In a previous phase 2 induction study, etrolizumab significantly improved clinical remission versus placebo in patients with moderately to severely active ulcerative colitis. We aimed to compare the safety and efficacy of etrolizumab with infliximab in patients with moderately to severely active ulcerative colitis.